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Regulation of aggregation by light is a useful phenomenon, but the role of the solvent is not often considered. Here, the authors report the development of photoinduced hydrous organic aggregates, emissive in the presence of both water and photoirradiation.

Combining antibody drug conjugates (ADCs) and tyrosine kinase inhibitors (TKIs) targeting HER2 has been shown to improve efficacy in patients with advanced HER2+ breast cancer. Here, the authors report a randomised phase 2b trial comparing neoadjuvant ARX788 (HER2 ADC) plus pyrotinib (HER1, HER2 and HER4 TKI) against neoadjuvant standard of care (docetaxel, carboplatin, trastuzumab, and pertuzumab) for the treatment of HER2+ breast cancer.

Entanglement entropy is a crucial quantity in several research fields, yet its calculation in higher-dimensional systems remains challenging. Here the authors develop a quantum Monte Carlo-based algorithm to efficiently extract large-scale entanglement entropy data and apply it to quantum critical systems.

Optimizing mechanical performance for polymer materials is frequently challenging, often require complex methods. Here the authors design an poly(ethylene glycol) material with enhanced mechanical properties by laser printing a micropillar and honeycomb micro-lattice.

The authors propose a design that equips a programmable metasurface with integrated capability for sensing and manipulating electromagnetic waves, allowing it to leverage the environmental information to enhance wireless system performance in complex environments.

Chiral emission from collective guided modes is demonstrated within a photonic crystal slab, showing an example of collective oscillations in the momentum space.

A synthetic biology approach was used to engineer Vibrio natriegens into a strain capable of bioremediating complex organic pollutants in saline wastewater and soils, thereby addressing notable threats to marine biosecurity.

Disruption of dendritic cell (DC) interstitial motility in the tumour microenvironment promotes immune evasion, and enhancement of DC interstitial motility offers a route for DC-centric immunotherapy.

The Einstein Probe has discovered a fast X-ray transient, EP240414a, associated with a broad-lined type Ic supernova. Its unusually soft spectrum and weak jet add to the diversity of stellar deaths and suggest a previously unknown Wolf–Rayet star explosion mechanism.

Understanding the genetic factors that regulate panicle architecture is important for improving rice yields. In this study, Li et al. demonstrate that the gene PTB1is critical for regulating panicle seed setting rate and pollen tube growth.

While Bell inequalities have been violated several times—mostly in photonic systems—their violations within particle physics experiments are less explored. Here, the BESIII Collaboration showcases Bell-violating nonlocal correlations between entangled hyperon pairs.

The synthesis of atom-thin amorphous films remains challenging as their thermodynamically favourable grains are neither two dimensional nor layered. Here a droplet-driven nanoribbon-to-film growth strategy is reported to achieve amorphous metal chalcogenides at the single-layer limit.

The introduction of sodium heparin passivates interface defects and enhances bonding between the electron transport layer and the perovskite layer in perovskite solar cells. The best-performing devices exhibit a certified PCE of 26.54% and maintain almost 95% of their initial performance after 1,800 h of maximum power point tracking.

In large prospectively enrolled validation cohorts of patients with cancer and controls and a prospective study of asymptomatic individuals with average risk for cancer, a multicancer early detection test based on plasma cell-free DNA genomics and fragmentomics showed encouraging accuracy in identifying ongoing disease as well as the tissue of origin.

Here the authors identify genetic loci for asthma in East Asians using multi-trait GWAS. A CD36 missense variant shows protective effects and is validated through multi-omics, offering insights into asthma mechanisms and precision therapy.

Targeted deletion of integrin-associated protein CD47 enhances long-term engraftment of human CD34⁺ cells in immunodeficient pigs lacking IL2RG and RAG2, enabling large-scale production of functional human immune cells.

The phenol industry faces a pressing sustainability challenge from the production of acetone as a by-product at a level far beyond its market. Here the authors develop an electro-biosystem that can efficiently convert such surplus acetone into valuable long-chain commodity chemicals.

A purely organic crystalline two-dimensional mechanically interlocked polymer comprising [c2]daisy chain units forms via preorganized crystallization and thiol–ene click chemistry. This polymer network can be exfoliated to give nanosheets with a 47-fold stiffness enhancement relative to the bulk parent.

Fang and colleagues show that the metabolite succinate can inhibit succinylation, and consequently protection from ubiquitin-mediated degradation, of the transcription factor FOXP3, with consequences on T_reg cell-suppressive function and IBD pathology.

Currently, there is limited understanding of the molecular subtypes of fumarate hydratase (FH)-deficient renal cell carcinoma (RCC). Here, the authors employ integrated genomics and transcriptomics to develop a CpG site-specific methylation signature for the identification of FH-deficient RCC, and to identify three distinct molecular subtypes for this rare but highly lethal kidney cancer.

Sphingosine-1-phosphate receptor 1 (S1PR1) is a drug target for inflammatory bowel disease (IBD), impacting immune cell movement, but current treatments carry immunosuppression risks. Here, the authors show that a Gi-biased S1PR1 agonist, SAR247799, protects the endothelial barrier in IBD models without affecting immune cell egress, offering a potential new treatment strategy.

Reducing platinum use is vital for sustainable hydrogen production via proton exchange membrane water electrolysis. Here, the authors report a Mo₂TiC₂ MXene-supported platinum nanocluster catalyst that requires minimal platinum content and operates efficiently for over 8700 h.

Comparing to Gossypium hirsutum, G. barbadense cotton lines have superior fiber quality but lower fiber yield. Here, the authors construct pangenome using 12 newly assembled G. barbadense genomes and 17 publicly tetraploid cotton genomes and reveal yield- and fiber-related diversity and interspecific gene flow.

Analysis of whole-genome sequencing data from 3,023 human genomes from mainland Southeast Asia identifies high genetic heterogeneity among populations in the region and many unique small and structural variants.

The African swine fever virus represents a threat to global pig production. Here, the authors determine the cryo-EM structures of ASFV RNA polymerase, and suggest that the M1249L subunit may modulate polymerase activity in cells.

The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.

Divergent catalytic asymmetric reactions for the selective formation of C(sp3)−H insertion and formal C(sp3)−O insertion products from the same precursors are rarely explored. Here, the authors report a ligand-controlled divergent asymmetric C(sp3)–H insertion and formal C(sp3)–O insertion reaction via vinyl cations, leading to the assembly of a range of chiral spiro and fused polycyclic pyrroles.

The Zn-N₃ on Zn-N₃@SC-PC breaks 1:1 stoichiometric interaction rule with acid gases due to its protruded structure for more coordination between Zn vacant orbital and acid gases, thus exhibiting supra-multi-molar adsorption phenomena (SO₂/Zn-N₃ = 6:1).

Jiang and colleagues identify ETV7 as a transcriptional node that skews CD8⁺ T cell transcriptional profiles toward exhaustion, consequently limiting antiviral and antitumor efficacy, and show that it can be targeted in CAR T cells to enhance efficacy.

Interferon-γ (IFNγ)-activated calcium/calmodulin-dependent protein kinase II (CAMK2) phosphorylates phosphoserine aminotransferase 1 (PSAT1) at serine 337 (S337), enabling glutathione peroxidase 4 (GPX4) interaction, promoting α-ketoglutarate-dependent PHD3-mediated GPX4 proline 159 (P159) hydroxylation and stabilizing GPX4 to counteract ferroptosis.

The accumulation of biomedical cohort data offers opportunities to better understand disease mechanisms. Here, the authors present UKB-MDRMF, a framework that predicts health risks for 1,560 diseases using data from the UK Biobank data.

A novel covalent inhibitor, ISM3312, targets the main protease of multiple human coronaviruses, including drug-resistant strains, and shows broad antiviral activity. It offers a promising therapeutic strategy against current and future coronavirus threats.

Aqueous Zn-ion batteries face challenges from water-induced reactions and unstable interfaces, drastically compromising their reversibility and cyclability. Here, authors introduce trace nonionic polysorbate additives to promote the formation of water-shielding double layer and to stabilize solid electrolyte interphase, achieving stable Zn-ion batteries.

This study shows how auditory cortex activation and cognitive function develop during a six-month follow-up after gene therapy in children with congenital deafness.

Jing et al., perform local injections of lipid nanoparticles carrying synthetic IL-2 and circRNAs encoding IL-2R–TLR4 chimeric receptors and anti-CA9 CARs to target renal tumor macrophages, thereby promoting their antitumorigenic potential in situ.