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Here, the authors perform a pan-genome-based genome-wide meta-analysis of six independent GWAS experiments in rice, demonstrating the potential of this approach to increase understanding of the genetic basis of, and genes underlying key rice traits.

The Hippo signalling pathway is commonly mutated across cancer types. Here, the authors identify 85 loss-of-function missense mutations within Hippo signalling genes and highlight the mechanisms underpinning mutations in MOB1 and NF2.

Jing et al., perform local injections of lipid nanoparticles carrying synthetic IL-2 and circRNAs encoding IL-2R–TLR4 chimeric receptors and anti-CA9 CARs to target renal tumor macrophages, thereby promoting their antitumorigenic potential in situ.

Controlling magnetization orientation and assembling high-coercivity micro-magnets at the microscale has been challenging due to harsh operational requirements and limited spatial precision. The authors present a stretchable linear magnet with programmable magnetization enabled by laser-activated phase-change microcells, achieving efficient and reversible reorientation under mild conditions.

High-temperature fuel cells often face bulk cracking due to insufficient fracture strength and stiffness. Here, the authors show that chemical hydration enhances cathode mechanical properties, significantly improving thermal cycling stability and overall performance in proton ceramic fuel cells.

The authors uncover a hidden tetragonal-orthorhombic phase transition pathway which provides an approach to engineer ___domain orientations and further remanent polarization in polycrystalline HfO₂-based ferroelectric films.

Rechargeable aqueous Zn metal batteries are impeded by dendrite growth and the hydrogen evolution side reaction. Here, authors develop a bifunctional Cu-In alloy interface to realize uniform Zn nucleation and prevent hydrogen evolution, enabling operation of Ah-level Zn metal pouch cells.

The difunctionalization of diazo compounds, traditionally with one nucleophile and one electrophile, is a powerful strategy. Here, the authors develop a path of electrochemical oxidative difunctionalization of diazo compounds with two different nucleophiles.

Understanding the atomic arrangement and binding nature of 2D materials with substrates is crucial to understand their properties and utilize their functions. Here, authors report that at high temperature graphene and α-Al₂O₃ substrate form a C-O-Al bond, having strong interactions, while interfacial structural relaxations of sapphire remain suppressed.

Magnetoelectric composites of magnetic and ferroelectric components are promising for their use in applications such as information storage. Here, the authors find that magnetic quasiparticles embedded in a ferroelectric film matrix show promising properties compared to the usual thin-film architectures.

Wearable sensors with edge computing are desired for human motion monitoring. Here, the authors demonstrate a topographic design for wearable MXene sensor modules with wireless streaming or in-sensor computing models for avatar reconstruction.

Fine turning the local configuration of single atoms into substrate is challenging. Here, the authors report that burying single atoms into subsurface lattice of substrate can stimulate more surficial active sites and thus promote the overall catalytic performance in methanol electrooxidation.

A method is reported that produces highly strong, tough and elastic 2D COF films, using a sacrificial go-between, which endows them with new properties, enhances their current applications and paves the way for new applications.

The authors of this manuscript identify that Gpr54 activation by its natural ligand Kisspeptin-10 can abrogate bone resorption. Mechanistically, Gpr54 recruits both active Src and the Dusp18 phosphatase, which causes Dusp18 to dephosphorylate Src at Tyr 416.

Efficient metabolic regulation is key for parasite growth. Here, the authors report that Toxoplasma alters its AMPK phosphorylation during the lytic cycle, which reprograms parasite’s metabolism to ensure metabolic needs at different stages are met.

Molecular flexiblity and conformational dynamics of chiral catalysts are not often taken into account in models of enantiodiscrimination. Here the authors design a catalytic system in which two conformers of the same catalyst can lead to axially chiral products of opposite absolute configurations.

A systematic design of light-absorbing molecules is challenging for them to satisfy multiple key requirements for efficient solar cell application. Here, the authors optimize halogen substitution position in terminal groups of acceptors for realizing ternary cells with efficiency approaching 20%.

A 2 nm displacement resolution of a centimetre-sized object in a 3 cm cavity is demonstrated.

Tandem repeats (TRs) have unique ability to drive a range of phenotype variations. Here, the authors survey rice TR variations based on 231 genome assemblies and the rice pan-genome graph, identify TR variations associated with expressed genes, and reveal expression TRs contributed to rice agronomic trait variations.

Constructing crossmodal in-sensor processing system based on high-performance flexible devices is important for the development of wearable human-machine interfaces. This work reports a bio-inspired spiking sensory neuron based on a flexible VO2 memristor and demonstrates a crossmodal in-sensor encoding and computing system.

Covalent organic frameworks (COFs) have remained difficult to grow as single crystals. Now, amphiphilic amino-acid derivatives that assemble in micelles in aqueous solutions have been shown to promote the growth of a variety of imine-bridged COFs into single crystals, in a step-by-step fashion, within their hydrophobic compartment.

Machines capable of magnetically controllable shape morphing and locomotion have diverse promising applications. Here, authors propose a scalable fabrication strategy that transforms 2D magnetic sheets into 3D soft magneto-active machines with customized geometries by incorporating origami folding.

There is a long-standing trade-off between high piezoelectricity and good temperature stability for piezoceramics. Here, authors combine phase boundary engineering and process engineering to relieve this relationship in (Pb, Zr) TiO3 piezoceramics.

We fabricated silicon heterojunction back-contact solar cells using laser patterning, producing cells that exceeded 27% power-conversion efficiency.

Multi-omic analysis of 100 clear cell renal cell carcinomas identifies four transcriptomic subgroups (IM1–IM4). IM4 is a high-risk subtype characterized by specific metabolic changes and a loss of lipid droplets.

Xu et al. developed and characterized a new animal model of maternal immune activation based on a parasite mimetic. They show that immune and behavioral abnormalities in adult offspring are reversed by adoptive transfer of regulatory T cells.

Magnetic phases that are stabilized by quantum fluctuations in low dimensions are rare. A thickness-dependent crossover from three-dimensional antiferromagnetism to a two-dimensional vestigial nematic state that is driven by fluctuations has now been observed.

The authors investigate the response of Archaea to experimental warming in a tallgrass prairie ecosystem. Warming was linked to reduced diversity and convergent succession, with further links to changed ecosystem function. Stochastic processes dominated community changes but decreased over time.

Soil microbes control the cycling of carbon, but how these communities will respond to climate changes is unknown. Here, 7 years of artificial warming decreased microbial richness and diversity, driven mostly by soil moisture loss.

The authors present ARPES and STM/STS measurements of the kagome superconductor CsV_3-xTa_xSb₅. For the x = 0.4 Ta-doped sample, they report evidence for a van Hove singularity perfectly aligned with the Fermi level, and that the superconducting transition temperature is maximized at this doping.

TFE3-translocation renal cell carcinoma (TFE3-tRCC) is a rare subtype of kidney cancer with no standard treatment options for the advanced disease. Here, the authors perform genomic and transcriptomic profiling of 63 untreated primary TFE3-tRCC tumours and reveal potential therapeutic targets.

Stress-induced instability of perovskite layers is a critical hurdle for commercialization of perovskite solar cells. Here, the authors introduce a long-alkyl-chain anionic surfactant additive to chemically ameliorate crystallization kinetics and demonstrate devices with long operational stability.

Implanted bioelectronic devices have proven useful for health sensing and therapy, while the interconnection of distributed implants remains challenging. Here, the authors demonstrate direct implant-to-implant wireless networking at the scale of the human body using metamaterial textiles.

Mutations in WDR62 are the second most common genetic cause of autosomal recessive primary microcephaly, yet the molecular mechanisms underlying this pathogenesis remain unclear. Here, authors demonstrate that WDR62 depletion leads to neural precursor cell depletion and microcephaly via WDR62-CEP170-KIF2A pathway that promotes cilium disassembly.

Multifilament surgical sutures functionalized with a conductive polymer and incorporating pledgets with capacitive sensors operated via radiofrequency identification can be used to monitor physicochemical states of deep surgical sites.

A moiré potential may play a role in determining the magnetic properties of a two-dimensional homo or heterostructure. Now, non-collinear spin structures are observed in twisted double bilayer CrI₃, providing a platform to engineer unusual magnetic textures.

Buffalo is an important livestock in Asia. Here, the authors present a comprehensive metagenomic analysis of the microbial communities present in different sites and compartments along the buffalo digestive tract.

Previously, the small molecule inhibitor of transcriptional enhanced associate ___domain (TEAD) MGH-CP1 has been described in stem cells. Here, the authors demonstrate the utility of MGH-CP1 in cancer therapy and find treatment to increase Akt pathway activation via TEAD-Vgll3 activation, presenting a rationale for combination with Akt inhibition.

The authors demonstrate all-spin synapses and neurons using ___domain wall-magnetic tunnel junctions, utilizing synergistic spin-orbit torque and Dzyaloshinskii-Moriya interaction. The intrinsic linearity is required for compact and energy-efficient bio-inspired hardware for neuromorphic computing.