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PKM2 acts as a critical nonmetabolic regulator of macrophage pyroptosis by increasing NLRP3 expression promoting NLRP3 inflammasome activation via nuclear translocation and enhancing STAT3 phosphorylation during acute liver failure.
We introduced mFusion, a method that integrates gene and neuroimaging data to identify disease-related genes in mental disorders. By analyzing gene interactions and PET data, mFusion successfully clusters disorders and highlight critical gene pathways.
Genetic and environmental factors shaping bacterial growth are explored using profiles of E. coli. Machine learning revealed glucose-dependent gene-chemical hierarchies and negative epistasis, highlighting mechanisms that maintain growth homeostasis.
Cryo-EM structure of the SARS-CoV-2 Delta Sprotein in complex with the Fab of neutralizing REGN10987, MD simulations of Omicron and other RBD variants, and ΔG calculations explain the role of individual RBD mutations in REGN10987 evasion.
Decreased fertility in middle-aged female mice is associated with age-related reductions in the cumulus-oocyte interaction and abnormalities in the microfilament structure of the zona pellucida surface.
Distinct genetic correlations have been identified between 21 atopic-gastrointestinal diseases pairs, but the correlated genomic loci converged on common molecular pathways.
RNA-binding protein HNRNPD promotes chondrocyte senescence in the pathology of OA by upregulating FOXM1, which lays a theoretical foundation for exploring new targets for the prevention and treatment of OA.
Establishment and characterization of a spontaneously immortalized fish muscle stem cell line (EfMS) from brown-marbled grouper with undiminished stemness and differentiation potential for the production of cell-cultured fish meat.
CLEAN-Contact leverages amino acid sequences and protein structural inference to predicts enzyme functions more accurately and confidently, illustrating its utility by predicting unknown functions of enzymes in Prochlorococcus marinus MED4.
Autologous fecal microbiota transplants improved post-antibiotic recovery of gut microbiota in cheetahs via recouping composition and engrafting specific taxa. Studying microbial therapies can elucidate host-microbe dynamics and improve animal care.
Detection of fortunate molecules by correlation-based single-molecule localization microscopy enhances signal-to-background ratio and improves spatial resolution, leading to better resolved single-molecule ensembles in a cellular system.
Antiviral immune function in both CD4 and CD8 memory T cells, which relies on effective ATP generation in mitochondria, involves the resident chaperone HSP60 by assisting the expression of multiples mitochondrial enzymes after cell activation
Biological processes are inherently 3D but often visualized in 2D. The open-source tool ThirdPeak allows non-specialists to analyze 2D/3D track data. It integrates seamlessly into existing workflows and provides valuable insights into live-cell data.
Multi-omics sheds light on the precise mechanisms of pancreatic functional transformation that underlie the two extreme digestion modes: non-ruminating mode (neonatal goats) and ruminating mode (adult goats).
Multi-omics techniques facilitate a comprehensive understanding of the function and regulatory mechanisms of SPF pheromones in Anurans, shedding lights on the protein pheromones evolutionary and multi-modal communication in vertebrates.
This study models early life stress (ELS) to observe sex-specific effects on fear memory formation using innovative unsupervised classification together with cellular metabolism alterations in key stress brain regions, highlighting sex-specific pathways in ELS.
Our proteome-wide Mendelian randomization study prioritized plasma ASIP and CTSS as causal proteins of skin cancer risk, highlighting the possibility of identifying novel therapeutic targets and disease biomarkers.
Response strategies to acute and chronic environmental stress in Arctic-breeding Lapland longspurs highlight key adaptive changes, including activation of the HPA axis, regulation of energy, and reproductive functions.
