Research articles

The circadian clock regulates the rhythmic expression of mir-219-1, mir-219-2, and mir219-3, and miR-219-5p contributes to circadian regulation by targeting bmal1b, highlighting a miR-219-5p-bmal1b negative feedback loop in the circadian circuit.

Comparison of the single-cell inner ear atlas between the highly regenerative Xenopus laevis and mice reveals evolution of auditory hair cells and sheds light on mechanisms for hair cell regeneration.

Wang et al. present the structures of two unique light-harvesting complexes from Roseospirillum parvum, enhancing the understanding of solar energy capture in purple phototrophic bacteria. These findings highlight the evolutionary diversity of light-harvesting complexes in purple phototrophic bacteria, revealing adaptations that may have originated from a common ancestor.

A hybrid imaging paradigm featuring structural, functional connectivity and meta-analyticfunctional decoding reveals spatially segregated subunits in the arcuate fasciculus, each withdistinct functional implications.

Protogenin regulates vertebral axial patterning in mammalian embryos by interacting with GDF11, enhancing GDF11/pSMAD2 signaling to facilitate trunk-to-tail HOX code transition and ensure proper expression of posterior HOX genes.

This study suggests that enhanced imputation quality in genome-wide association studies, using a Japanese population-specific reference panel, leads to the discovery of rare, trait-associated loci.

Hepsin stimulates hepatocyte proliferation via the EGFR-Raf-MEK-ERK pathway to promote liver regeneration and recovery after partial hepatectomy without adverse effects, suggesting its therapeutic potential for liver resection and transplantation

Seasonal variations of temperature modify coral thermal tolerance threshold for Pocillopora verrucosa species while Acropora spp. remain unchanged when exposed to the same in situ conditions.

A new touchscreen-based platform for conducting prey capture experiments offers real-time processing capabilities to simulate predator-prey interactions. This innovative approach provided insights on strike patterns and learning during prey catch in lizards.

Extracellular vesicles from adipose-derived rat stromal cells embedded in a thermoresponsive gel display pro-regenerative and immunomodulatory effects, resulting in the healing of colorectal anastomosis in rats.

Teslin Tlingit knowledge and ecological methods shed light on Chinook salmon in northern river ecosystems, demonstrating links between the health of salmon, riparian forests, bears, and wider social-ecological systems in the Yukon.

Animal experiments and osteoblast and osteoclast co-culture systems show IGF-1 synonymous mutation c.258 A < G ameliorates senile osteoporosis.

Kasuya et al. identified a novel KCNE family member, KCNE6, in zebrafish, which is expressed in the heart and contributes to cardiac excitability by producing a slowly activating current with KCNQ1, similar to the I_Ks current. This discovery enhances understanding of the evolutionary role of KCNE family members in modulating KCNQ1 and provides insights into the physiological diversity of potassium channel regulation across vertebrates.

WDR26 and muskelin mediate the formation of two distinct CTLH E3 ligase complexes that have different targets. Inhibition of mTOR signalling regulates muskelin-specific CTLH complex activity in human cells and leads to muskelin autoregulation.

DeChat is a novel error correction tool for Nanopore R10 reads (<2% error), combining de Bruijn graphs and variant-aware alignment to preserve repeats and haplotypes while reducing errors up to 100x, outperforming existing methods.

Genome assembly of Hedylidae (American moth-butterfly) reveals conserved visual genes and strong selection pressure on color vision opsins, particularly within the blue opsin’s functional ___domain, suggesting a convergent evolutionary event linked to nocturnality.

Experimentally determined structure of 2-nitroimidazole hydrolase and its comparison with other related enzymes shed light on the mechanism of action of an unusual antibiotic degrading enzyme in soil bacteria.

Cryo-SEM reveals a highly organized glycocalyx ultrastructure in human cells and sponges, with AFM measurements suggesting that evolutionarily preserved glycocalyx morphologies are formed by self-assembly of glycoconjugates.

By shedding light on the complexities of primary and recurrent multifocal bladder tumors, this research provides valuable insights and resources for further exploration of the multifocality and recurrence of bladder cancer.

This study explores how viral N-linked glycans play a role in the interaction between chloroviruses glycoproteins and key receptors of the innate immune system.