Research articles

Characterization of the multi-surface interaction between Lgl and the aPKC/Par6 complex reveals the mechanistic basis for a processive phosphorylation of Lgl, highlighting an important role of Par6 in regulating epithelial polarity.

β-lactamases in E. coli universally promote cooperative resistance, enabling cross-protection, efficient conjugation under antibiotic stress, and legacy effects driven by extracellular enzyme activity.

SwinCell, a transformer-based model, enables precise 3D segmentation of dense and complex cellular images by combining flow prediction with attention mechanisms. This approach ensures robust performance across diverse imaging modalities.

Zebrafish AHDS models reveals an important role for maternal thyroid hormone in establishing the hindbrain-blood-barrier via vegfaa signaling regulation in pax6a neuroprogenitors.

This study identifies cycling mRNAs, miRNAs, gene networks and mRNA-miRNA co-expression pairs in the cortex, hypothalamus, and corpus striatum, providing a searchable catalogue to help refine future analyses of the CNS.

FRET-MD spectrometry reveals atomic-level interfaces involved in oligomerization of the human secretin receptor in live cells, offering mechanistic insights into their quaternary structure and a framework for future application to other GPCRs and membrane proteins.

Derivation and characterization of patient-specific human trophoblast stem (TS) cell lines from chorionic villus biopsies provide a valuable, clinically linked resource to broaden genetic diversity in TS cell models and advance studies of placental development.

The authors developed a patient-specific microphysiological system using the LumeNEXT microfluidic platform to more accurately recreate the prostate cancer metastatic bone tumor microenvironment.

Locally delivered H₂S slow-releasing hydrogel promotes lipid accumulation, adipocyte hypertrophy, macrophage infiltration, and fibrosis in mouse adipose tissue, offering a practical implementation strategy for H₂S-based interventions.

Clostridium innocuum uses D-allulose with alsE, which is otherwise limited in distribution among gut bacteria, and findings that native E. coli cannot readily utilize D-allulose suggest that this sweetener has small effects on gut microbiota.

Human, mouse and iPSC-derived microglia demonstrate that interaction between GRN and phagocytic receptors can rescue (MERTK) or worsen (AXL) FTD-disease features. CSF MERTK maybe a biomarker of symptomatic disease conversion in genetic FTD.

m6A demethylase ALKBH5 regulates endometrial fibrosis through FABP4 mRNA m6A methylation and lipid metabolism.

Extracellular zinc release in glaucoma may affect the key retinal neurotrophic factor PEDF, which binds zinc at intermolecular sites and forms dimers and trimers, losing the ability to recognize PEDF-R and exhibit neurotrophic and antiangiogenic activity.

This study presents cryo-EM structures of H₄R–G_i and H₁R–G_i/G_s complexes, revealing distinct histamine recognition, activation mechanisms, and a critical determinant of G protein selectivity in H₁R and H₄R.

The My Baby Biome Study demonstrates that three gut microbiome community clusters exist in infants in the United States. These compositions vary on the prevalence and abundance of Bifidobacterium and impact risk for the development of atopic disease.

A transcriptome atlas of Xenopus tropicalis reveals the role of the immune-reproductive trade-off mediated by metabolic reprogramming in maintaining homeostasis from the perspective of inter-organ crosstalk.

Spatial connectivity between kelp forests and sandy beaches, in terms of kelp subsidies, is highly localized and primarily dependent on kelp canopy biomass. However, attributes of the beach including width and orientation are also important.

Super-enhancers drive TFAP2A-mediated metabolic reprogramming and SLC7A8 oncogene activation in uveal melanoma, identifying epigenetic vulnerabilities for precision therapy.

Distinct hippocampal-cortical systems support the encoding and sequencing of narrative events during ongoing comprehension, revealing how episodic memory integrates past and present information into coherent narratives.

Mycobacterium tuberculosis (M.tb) infection of human alveolar macrophages reveals a variably expressed gene network with inter-individual variability, guiding future studies to determine individual risk of M.tb infection and tuberculosis disease.