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Explicit training with zoo-morphic objects—as opposed to other training regimes—uniquely induces a human-like “Animal bias" in DNNs, suggesting that this bias in humans can be explained by humans’ learning history.
Cognitive computations in transitive inference (TI) tasks involve a time-locked anti-correlation between beta and gamma local field potential frequency bands in the prefrontal cortex. This interplay is modulated by the complexity of TI problems.
Schistosoma sex-biased Bantam and miR-1989 microRNAs shed light on the roles of ovarian development and egg production in females by targeting Wnt signaling pathway.
A domestication strategy to cultivate efficient and resilient functional microbiome for addressing phenolic wastewater challenges sheds light on the artificial construction of microbiome for the engineering application of treating industrial wastewater.
Combining proteolysis targeting chimeras that target the same oncogenic cell surface proteins (EGFR, HER2 and MET) as respective antibodies, improved antibody internalization and enhanced the cytotoxicity of a HER2-targeting antibody drug conjugate.
Biochemical and structural characterization of the full-length CdaA reveals that efficient synthesis of the second messenger cyclic di-AMP requires membrane-bound cyclase enzyme.
Extracellular vesicles derived from carcinoma-associated fibroblasts deliver lncRNA MAPKAPK5-AS1 into hepatocellular carcinoma cells to promote malignant proliferation and tumor growth.
Mouse model of developmental and epileptic encephalopathy sheds light on the role of Integrin-K+ channel_Complex in the context of neurodevelopment and associated pathology.
A behavioural analysis on the parasitic ant cricket suggests that this species employs two escape strategies to avoid ants, in particular, by switching strategies to more effectively avoid host ant species than non-host species.
GeoPoc uses geometric graph learning and protein structure data to predict optimal temperature, pH, and salt concentration for microbial proteins. Achieving high accuracy, it outperforms existing methods and identifies key properties for enhancing thermostability.
Dexmedetomidine promotes sleep and maintains the coordination of circadian rhythms with the external environment by activating SCNVIP neurons through the α2 adrenoceptor.
Metabolic modeling of single-cell and time-course omics data reveals temporal and cell-state specific metabolic dependencies during the epithelial-mesenchymal transition (EMT) and their impact on clinical outcomes of lung adenocarcinoma.
Use of transposon-sequencing (Tn-seq) to explore the genetic basis underlying the incompatibility of the beta-rhizobium Paraburkholderia phymatum STM815 with soybean reveals that in the absence of the nodulation factor NodS, it could nodulate this agriculturally important crop.
MIF2GO leverages up to six biological modalities to enhance protein function annotation. It outperforms state-of-the-art methods, showing robustness and generalizability across species, while offering insights into modality-function associations.
Identification of shared genetic determinants of cardiovascular and cerebrovascular diseases, along with cardiometabolic risk factors, reveals the role of blood pressure and lipid traits, which may facilitate the development of new drug targets.
This study identifies SMEK1 as a novel regulator of histone lactylation and a potential therapeutic target for mitigating neuroinflammation and enhancing recovery after AIS.
Local manipulation of orexin signaling reveals that the anteromedial ___domain of the OT is the crucial region that integrates odor information and metabolic signals and directs appropriate odor-guided feeding behavior according to metabolic status.
