Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Differentiating neural precursors exhibit soma-wide actin oscillations and arresting actin modulates calcium signaling features such as spike frequency and time-delayed cross correlations suggesting cytoskeletal dynamics may tune information flow in neural cells.
Characterization of the multi-surface interaction between Lgl and the aPKC/Par6 complex reveals the mechanistic basis for a processive phosphorylation of Lgl, highlighting an important role of Par6 in regulating epithelial polarity.
β-lactamases in E. coli universally promote cooperative resistance, enabling cross-protection, efficient conjugation under antibiotic stress, and legacy effects driven by extracellular enzyme activity.
SwinCell, a transformer-based model, enables precise 3D segmentation of dense and complex cellular images by combining flow prediction with attention mechanisms. This approach ensures robust performance across diverse imaging modalities.
Zebrafish AHDS models reveals an important role for maternal thyroid hormone in establishing the hindbrain-blood-barrier via vegfaa signaling regulation in pax6a neuroprogenitors.
A comparative mitogenomic study reconstructs the ancestral RNA editing site content across angiosperms and suggests that the post transcriptional processing-derived stop codon-lacking transcripts predate the divergence of angiosperms.
Structure-function relationship of the vibrissa follicle and associated afferents are revealed by synchrotron X-ray imaging of rat vibrissae with distinct functions.
This study identifies cycling mRNAs, miRNAs, gene networks and mRNA-miRNA co-expression pairs in the cortex, hypothalamus, and corpus striatum, providing a searchable catalogue to help refine future analyses of the CNS.
FRET-MD spectrometry reveals atomic-level interfaces involved in oligomerization of the human secretin receptor in live cells, offering mechanistic insights into their quaternary structure and a framework for future application to other GPCRs and membrane proteins.
Derivation and characterization of patient-specific human trophoblast stem (TS) cell lines from chorionic villus biopsies provide a valuable, clinically linked resource to broaden genetic diversity in TS cell models and advance studies of placental development.
Paired transcriptome and proteome profiling throughout the silkworm’s developmental life cycle offers a comprehensive resource revealing stage-specific and conserved expression dynamics across holometabolous insects.
Integrative molecular modelling of a mitochondrial crista demonstrates a pipeline for constructing biologically representative systems and addressing interactions in complex environments.
Macrophage-specific genetic ablation of the EMT inducer ZEB1 reveals its pivotal role in intracellular cytokine trafficking, boosting cytotoxic T cell abundance and immune responses, thereby reducing tumor growth and metastatic colonization in mice.
Integrative anatomical, molecular, behavioral, and modeling evidence suggests that higher dopamine D1 receptor expression in prefrontal cortical parvalbumin neurons in marmosets likely contributes to their higher distractibility relative to macaques.
The authors developed a patient-specific microphysiological system using the LumeNEXT microfluidic platform to more accurately recreate the prostate cancer metastatic bone tumor microenvironment.
Clostridium innocuum uses D-allulose with alsE, which is otherwise limited in distribution among gut bacteria, and findings that native E. coli cannot readily utilize D-allulose suggest that this sweetener has small effects on gut microbiota.
Human, mouse and iPSC-derived microglia demonstrate that interaction between GRN and phagocytic receptors can rescue (MERTK) or worsen (AXL) FTD-disease features. CSF MERTK maybe a biomarker of symptomatic disease conversion in genetic FTD.
circGIGYF1 inhibits colorectal cancer stemness and metastasis by promoting HOXD13 ubiquitination via WWP2, thereby suppressing Wnt/β-catenin pathway through decreased CTNNB1 expression, revealing a novel therapeutic target for colorectal cancer.
Anterior cingulate cortical neurons exhibit membrane resonance at theta frequencies, and their synaptic transmission to the mediodorsal thalamic nucleus shows facilitation at theta frequencies.
