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Epstein-Barr virus is associated with increased cancer risk. Here, the authors analysed two population-based prospective cohorts in Southern China to examine the association between increased seropositivity and the risk of multiple cancer types.

Radiation-induced liver damage is an important side-effect of radiation as a cancer therapy. Here, the authors identify pyroptosis protein gasdermin D as a key driver of liver injury and a potential therapeutic target to alleviate this damage.

Epithelial malfunction is an unmet critical challenge in trachea repair. Here, Chen et al. developed a multiplexed hydrogel to promote tracheal repair with native-like epithelium in pre-clinical models, exhibiting clinical translation potential.

In situ methods for water quality monitoring is crucial for global water use and management, though many conventional sensors have slow response time and are non-recyclable. Here, the authors report a recyclable amphiphobic dielectric material for fast monitoring of water pollutants.

Ultrafast magnetic resonance spectroscopic imaging enables non-invasive high-resolution metabolic imaging of the whole human brain under healthy and diseased conditions.

While Bell inequalities have been violated several times—mostly in photonic systems—their violations within particle physics experiments are less explored. Here, the BESIII Collaboration showcases Bell-violating nonlocal correlations between entangled hyperon pairs.

Optimizing mechanical performance for polymer materials is frequently challenging, often require complex methods. Here the authors design an poly(ethylene glycol) material with enhanced mechanical properties by laser printing a micropillar and honeycomb micro-lattice.

The Einstein Probe has discovered a fast X-ray transient, EP240414a, associated with a broad-lined type Ic supernova. Its unusually soft spectrum and weak jet add to the diversity of stellar deaths and suggest a previously unknown Wolf–Rayet star explosion mechanism.

The authors present a 3.5-million-year-long pollen record from the Zoige Basin of the eastern Tibetan Plateau, 3,442 m above sea level. The ~5,000 pollen assemblages retrieved from the core reveal many ecosystem transitions during this time and, when correlated with climatic curves, indicate what effects future warming may have on regional vegetation.

In large prospectively enrolled validation cohorts of patients with cancer and controls and a prospective study of asymptomatic individuals with average risk for cancer, a multicancer early detection test based on plasma cell-free DNA genomics and fragmentomics showed encouraging accuracy in identifying ongoing disease as well as the tissue of origin.

Functional proteomics enhances cancer research by identifying biomarkers and therapeutic targets. Here, the authors develop a cancer functional proteomics resource and introduce a resource using reverse phase protein arrays and antibodies targeting key pathways. To improve accessibility, they introduce DrBioRight, an AI-powered platform for intuitive data analysis and visualization.

The microglia–neuron interactions contributing to neuronal hyperexcitability are unclear. Here, the authors show how GABA and C3 signaling coordinate microglial engulfment of inhibitory synapses, driving excitatory–inhibitory imbalance and neuronal hyperexcitability in epilepsy.

Highly specific glycan labels remain scarce, limiting their use in many applications. Here, authors report recombinant glycan affinity binders based on sialidase mutants, which are enzymatically inactive but preserve specificity for sialoglycans.

Currently, a serious public health crisis caused by PFAS is of great concern worldwide. Here, the authors propose a treatment-train strategy that combines Zn-based EC with the existing AC/AER devices to enable the broad-spectrum removal of hundreds of PFAS from fluorochemical production effluents.

Nuclear SREBP2 forms nuclear condensates through its N-terminal intrinsically disordered region, which is essential for the transcriptional activation of lipogenic genes.

This study investigates the role of 3,4-dihydroxyphenylacetaldehyde synthase (DHPAAS) in mosquito cuticle formation, a key factor in their development and survival. The findings reveal that DHPAAS is essential for abdominal integrity and egg development, with unique structural features suggesting a novel oxygen delivery mechanism.

C−H bond functionalization is widely used in chemical synthesis but achieving regio- and stereoselectivity is still challenging. Here, the authors report the mechanism of three Fe(II)/α-ketoglutarate-dependent dioxygenases in bicyclomycin synthesis, which depicts the natural strategy to sequentially hydroxylate specific C–H bonds of similar substrates (cyclodipeptides)

Transition-metal-catalyzed asymmetric multicomponent reactions with two similar substrates often suffer from the lack of strategies to control the chemo-, regio-, and stereoselectivity. Here, the authors report a Cu(I)-catalyzed asymmetric radical 1,2-carboalkynylation of two different terminal alkynes and alkyl halides with chemo-, regio-, and stereoselectivity.

Circular organic crystals could be useful as components in flexible organic optoelectronics, but this shape is not easy to obtain. Here, the authors report a method for the formation of quasicircular crystals by photoinduced bending then delamination of a parent crystal.

Analysis of whole-genome sequencing data from 3,023 human genomes from mainland Southeast Asia identifies high genetic heterogeneity among populations in the region and many unique small and structural variants.

Controlling phase transitions in MoOx semiconductors is challenging. Here, the authors develop a lab-on-device system to modulate proton intercalation, achieving conductance modulation and enabling electrochemical memory and neural network applications.

Xue et al. develop a foundation model for spectral analysis. It excels in multiple tasks, such as denoising spectra and quantifying trace molecules, and is especially promising in identifying metabolic biomarkers of diseases such as stroke, Alzheimer’s disease and prostate cancer.

Currently, there is limited understanding of the molecular subtypes of fumarate hydratase (FH)-deficient renal cell carcinoma (RCC). Here, the authors employ integrated genomics and transcriptomics to develop a CpG site-specific methylation signature for the identification of FH-deficient RCC, and to identify three distinct molecular subtypes for this rare but highly lethal kidney cancer.

This work introduces ChAIR, a droplet-based tri-omic tool that enables the simultaneous profiling of the transcriptome, chromatin accessibility and chromatin conformation in single cells.

The storage of solar wind-derived water of impact glass beads exhibits a dichotomy distribution in the lunar soils.

Tang, Yue, Xu and colleagues map the proteome of several thousand individuals over a 9-year period to identify potential biomarkers of ageing and of age-associated diseases.

Targeted degradation has the potential to treat diseases associated with pathological protein build up. Here, the authors report on an oligo-PROTAC which degrades FUS, a protein associated with frontotemporal dementia, demonstrating delivery on DNA nanoflowers for increase blood-brain barrier crossing and retention.

Integrating multiple contradictory properties into a single material is crucial for dynamic soft tissue defect repair but difficult. Here, the authors report a super-structured porous hydrogel that integrates contradictory properties including mechanical properties of high strength, stiffness, toughness and fatigue resistance, alongside biological properties of anti-adhesion and pro-healing.

Worldwide, the number of only-child families is increasing. This research examines how growing up without siblings affects adult brain structure, function and connectivity, cognition, personality and mental health.

A novel covalent inhibitor, ISM3312, targets the main protease of multiple human coronaviruses, including drug-resistant strains, and shows broad antiviral activity. It offers a promising therapeutic strategy against current and future coronavirus threats.

Chen at al. show that CHD1 loss in SPOP-mutated prostate tumors confers castration resistance by increasing SREBP2-mediated cholesterol synthesis and subsequent androgen supply, an effect counteracted by combined androgen and cholesterol inhibition.

The authors show that SARS-CoV-2-specific T cells in the lung are key to fighting infection and persist after viral clearance, contributing to long-term immunity and protection.

Earth-abundant TiO₂ is a promising negative electrode material for low-cost sodium-ion batteries. Here, authors show that ordered rocksalt NaTiO₂ nanograins are in situ formed by electrochemically cycling with Na⁺ ions in anatase TiO₂, which determines the pseudocapacitive high-rate capability.

Unfairness in AI healthcare models arise from biased correlations between sensitive attributes and disease data. Here, the authors show that the Attribute Neutral Framework reduces these biases and enhances fairness without compromising diagnostic accuracy.

The parasitic absorption caused by nonradiative damping of plasmonic effects limits the light utilization efficiency of optoelectronics. Here, authors employ green fluorophore and nickel oxide to recycle plasmon energy, achieving maximum device efficiency of 19.51% for flexible organic solar cells.

Prenatal exposure to phthalates has been linked to metabolic and neurodevelopmental disruptions but the mechanisms remain unclear. Here, the authors show that prenatal phthalate exposure alters newborn metabolite profiles, particularly in tyrosine and tryptophan pathways, which are associated with infant neurobehavioral outcomes.

Field emission electron sources offer high brightness and small energy spread, but their use is limited by ultra-high vacuum requirements. Here, a focused ion beam-fabricated LaB₆ nanoneedle is presented that achieves ultrahigh brightness and stable low-vacuum emission via self-heating