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The authors show that ELL3 maintains chromosomal ploidy by promoting spindle assembly and driving chromosome movement in oocytes. Deficiency of ELL3 results in oocyte aneuploidy and may lead to early miscarriage.

Replacing ZnSeS with a thickened ZnSe layer in green InP-based QD-LEDs improves the efficiency and lifetime, boosting electron injection and reducing leakage, enabling 26.68% external quantum efficiency and 1,241 h T₉₅ lifetime.

Endothelin-1 activation after SARS-CoV-2 infection leads to vascular permeability, chondrocyte senescence, osteoclast activation and cyst formation in affected joints of hamsters, which can be alleviated using macitentan. Joint injury was also seen in two patients after COVID-19 infection.

The underlying mechanisms of central nervous system regulation of age-dependent obesity remain unclear. Here, the authors show hypothalamic SLC7A14 plays a role in age-induced lipolysis impairment by the brain–gut–adipose tissue axis.

The interfaces in perovskite solar cells are critical to the device performance. Li et al. tune the bond strength of the interfacial molecule with the perovskite and the electron transport layer, increasing the power conversion efficiency of the cells.

Diploid potatoes are typically self-incompatible, complicating efforts to breed diploid cultivars. Here the authors report map-based cloning of the S-locus inhibitor (Sli) gene in potato which encodes a non S-locus F-box protein that is expressed in pollen and can functions like a general S-RNase inhibitor to overcome self-incompatibility.

A comprehensive transcriptomic survey of the pig could enable mechanistic understanding of tissue specialization and accelerate its use as a biomedical model. Here the authors characterize four distinct transcript types in 31 adult pig tissues to dissect their distinct structural and transcriptional features and uncover transcriptomic variability related to tissue physiology.

Developing highly active and stable oxygen evolution electrocatalysts is crucial for enabling large-scale hydrogen production from seawater. Here, authors report a robust O₂-producing electrode for alkaline seawater, highlighting the critical role of distributed sites near the catalytic sites.

Primary biliary cholangitis is a rare, chronic immune-mediated liver disease triggered by environmental exposures in genetically susceptible individuals. Here, the authors investigate the functional mechanism underlying the association of 19p13.3 variants with primary biliary cholangitis.

The foundry-compatible platform could facilitate integration of phase change materials for reconfigurable photonics and open up the possibility of integrating excellent optoelectronic materials into future silicon photonic process design kits.

The codling moth, Cydia pomonella, is one of the major pests of pome fruit (apples and pears) and walnuts. Here, the authors sequence and analyze its genome, providing insights on olfactory and detoxification processes that may underlie its worldwide expansion.

The efficiency of deep-ultraviolet light sources is critical for applications like disinfection. Here, the authors employ a novel decoupling strategy using GaN templates to fabricate 280 nm vertical injection diodes, achieving a light output power of 65.2 mW at 200 mA.

RNA polymerase II (Pol II) transcription factories play a central role in gene expression and 3D chromatin organization. Here, the authors demonstrate that RUVBL2 directly regulates Pol II clustering at active gene promoters.

Leveraging long-chain dithiol ligand exchange, active image sensors based on PbS colloidal quantum dots enable near-infrared low-dose image sensing and image communication with detectivity exceeding 10¹⁴ Jones.

Two chiral enantiomers, R- and S-BBTI, are found to efficiently emit near-infrared circularly polarized phosphorescence with a large dissymmetry factor of 0.013 in dilute solutions.

The formal C–C bond insertion into aldehydes is an attractive methodology for the assembly of homologated carbonyl compounds but the homologation of aldehydes has been limited to diazo approach and the enantioselective reaction was rarely developed. Here, the authors report an asymmetric formal C–C bond insertion into aldehydes through diyne cyclization strategy

The authors demonstrate a programmable topological photonic chip with large-scale integration of silicon photonic nanocircuits and microresonators that can be rapidly reprogrammed to implement diverse multifunctionalities.

Zhang, Liu and colleagues identify and characterize cell death in rapidly proliferating CD8⁺ T cells resulting from excessive ammonia accumulation and subsequent lysosomal dysfunction and mitochondrial damage.

Proton exchange membrane electrolyzers hold promise for ethylamine synthesis from acetonitrile, yet local acidity fosters proton reduction. Here, authors systematically screen metal catalysts, verifying their effectiveness in such electrolyzers.

Here, Xian et al. use phosphoproteomics to identify that the Shigella effector OspG interacts with a regulator of Cullin-RING ubiquitin ligases to promote the ubiquitination of septins and consequent inhibition of septin cage formation.

Arabidopsis α-Aurora kinase regulates plant cytokinesis by phosphorylating the microtubule-associated protein MAP65-3, which controls the dynamic organization of the phragmoplast structure essential for cytokinesis completion.

Photo-crosslinking polymerization facilitates precise control of hydrogel formation for various applications including tissue engineering, but most existing photo-crosslinking methods fail to achieve deep-tissue penetration, especially within bone structures. Here the authors report a strategy of low-dose X-ray-activated polymerization that enables deep-tissue hydrogel formation.

Here the authors study diet-induced weight gain/loss to identify chromatin architectures in adipose tissue (AT) associated obesity in a pig model. They found parallels and species-specific regulatory elements in humans and pigs that underpin AT specialization.

Here, the authors find that ferroelectric skyrmions can be sustained in [(PbTiO₃)₂/(SrTiO₃)₂]_m ultrathin superlattices. The period-thickness relationship of skyrmions in the ultrathin PbTiO₃ layers breaks Kittel’s law.

Tumor hypoxia is a major limitation in radiotherapy, and strategies to address this often fail due to high oxygen consumption. Here, the authors report a nanomaterial assembly for the simultaneous reduction in mitochondrial respiration and to supply oxygen to potentiate radiotherapy.

The SARS-unique ___domain (SUD) of SARS-CoV-2 plays important roles in virus life cycle. Here the authors determine the crystal structure of SARS-CoV-2 SUD and perform a compound screen, which identify theaflavin 3,3’-digallate as a potent SUD binder that exhibits anti-SARS-CoV-2 activity.

Caerulomycins and collismycins are two types of 2,2’-bipyridine natural products that are biosynthesized via a hybrid NRPS-PKS pathway, but the details of their biosynthesis were unknown. Here, the authors elucidate their biosynthetic pathways, validate the generality of 2,2’-bipyridine formation, and clarify the process for 2,2’-bipyridine furcation.

Optical nonreciprocity through magneto-optical effects requires bulky apparatuses and strong magnetic fields, while magnetic-free approaches are difficult to implement. Here, the authors use optically-induced magnetisation in an atomic ensemble to get 50 dB of isolation over a large power dynamic range.

Seawater electroreduction is a promising technique for producing hydrogen, but it is hindered by cathodic Mg2 + /Ca2+ precipitation. Here, the authors propose a microscopic bubble/precipitate traffic system that releases small-sized bubbles across the cathode to repel Mg2 + /Ca2+ precipitates from almost the entire surface area of the catalyst.

Endothelial dysfunction has been shown to occur in HFpEF and we know that statins can target endothelial dysfunction by inhibiting miR-133a. Here the authors show that statins improve diastolic dysfunction in HFpEF by increasing the levels of a circRNA which, in turns, binds to miR-133a modulating its downstream targets.

Finding the process parameters in molecular beam epitaxy for a specific density of quantum dots is a multidimensional optimization challenge. Here, the authors demonstrate real-time feedback controlled self-assembled InAs/GaAs QDs growth based on machine learning (ML) outputs.

The authors report a computational strategy to simulate the hydrolysis and ammonolysis of N₂O₅ in aerosols using high-level quantum chemical methods. The computational results reveal a complete picture of the reactive uptake of N₂O₅ by atmospheric aerosols with or without NH₃.

The device’s electroluminescence efficiency is vital to reduce non-radiative voltage losses and boost organic solar cell performance. Here, the authors demonstrate that this efficiency is influenced not only by the decay of charge transfer states but also by the dissociation of singlet states.

In 2014 China proposed an ultra-low emissions policy for coal-fired power plants to reduce emissions. Using comprehensive nationwide stack emissions monitoring data, Tang et al. show reductions in excess of 60% for SO₂, NO_x and particulate matter emissions since 2014, even as power generation overall increased.

Non alcoholic fatty liver disease (NAFLD) associates with an elevated risk of developing hepatocellular carcinoma (HCC). Here, the authors find that Nogo-B, an endoplasmic reticulum resident protein, is upregulated by lipid uptake and acts as an oncogene in NAFLD-associated HCC by promoting lipid droplet breakdown by lipophagy and triggering Hippo pathway dysregulation

Glycogen can be metabolized via glycogenolysis and the pentose phosphate pathway as well as into the production of UDP glucose, which when secreted can bind the P2Y₁₄ receptor. Here the authors show how these glycogen metabolism pathways contribute to proinflammatory macrophage activation and susceptibility to sepsis.

Using data from long-term nationwide observations and multi-level rainfall manipulative experiments, this study reveals that rice yield reductions due to extreme rainfall in China were comparable to those induced by extreme heat over the past two decades. Further projections highlight the increasing risk of rice yield reductions induced by extreme rainfall by the end of this century.

Analysis of tumor samples from patients with nasopharyngeal carcinoma shows that gemcitabine plus cisplatin chemotherapy activates a unique population of innate-like B cells, which enhance the cytotoxic CD8⁺ T cell response and are associated with better clinical outcomes.

Electrolytic water splitting under harsh conditions is limited by poor lifespan of the electrodes. Here, authors report alternating electrolysis approaches that realize prompt and periodic repair of a Ni electrode via the co-action of Co²⁺ and Na⁺ ions, leading to prolonged operation times.