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Showing 1–50 of 7462 results
Advanced filters: Author: Christopher A. Green Clear advanced filters
  • A data-efficient deep learning model developed to predict ground-state and photophysical properties of molecules and nanomaterials by learning many-body Green’s functions achieves an accuracy surpassing the state-of-the-art density functional theory calculations.

    • Christian Venturella
    • Jiachen Li
    • Tianyu Zhu
    Research
    Nature Computational Science
    Volume: 5, P: 502-513
  • The neural processes involved in memory formation for realistic experiences remain poorly understood. Here, the authors found that ripple-like activity in the human hippocampus and neocortex tracks key moments during movie watching and predicts which events are later remembered.

    • Marta Silva
    • Xiongbo Wu
    • Lluís Fuentemilla
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11
  • How the cortex generates movement to achieve different tasks remains poorly understood. Here the authors show that the cortex serializes motor control by first performing task-specific computations in dorsal premotor cortex in order to then generate task-independent commands in primary motor cortex.

    • Simon Borgognon
    • Nicolò Macellari
    • Grégoire Courtine
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18
  • Telomere maintenance by telomerase depends on the correct assembly and the recruitment of the enzyme complex. Here, the authors reveal that the RNA/DNA binding proteins NONO, SFPQ, and PSPC1 interact with telomerase via the hTR RNA template, facilitating telomerase trafficking out of Cajal bodies and recruitment to the telomere.

    • Alexander P. Sobinoff
    • Jadon K. Wells
    • Hilda A. Pickett
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15
  • Most metabolic studies using traditional procedures fail to reveal the spatial patterning associated with metabolic flux and cellular metabolism within tissue microenvironments. Here, the authors show the application of multi-scale microscopy, machine learning-based image segmentation and spatial analysis to map the fate of nutrient-derived 13C across spatiotemporal scales.

    • Aliyah Habashy
    • Christopher Acree
    • Rafael Arrojo e Drigo
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16
  • Understanding how copper nanoparticles evolve under electrochemical conditions is crucial for the development of selective CO2 reduction electrocatalysts. Here the authors prepare well-defined nanocrystals and use advanced operando imaging and spectroscopic techniques to reveal the Cu–CO species-driven dynamic evolution of Cu electrodes.

    • Yao Yang
    • Julian Feijóo
    • Peidong Yang
    Research
    Nature Catalysis
    Volume: 8, P: 579-594
  • Iron has been shown to be necessary for the activation and differentiation of CD8+ T cells. Here the authors investigate changes in CD8+ T cell metabolism in iron limiting conditions and find that aspartate is increased yet downstream nucleotide synthesis is suppressed and addition of exogenous aspartate partially rescues T cell function.

    • Megan R. Teh
    • Nancy Gudgeon
    • Hal Drakesmith
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18
  • Pocock et al. reveal that transient activation of 5′ AMP-activated protein kinase and estrogen-related receptor drives robust maturation of multicellular human cardiac organoids, enabling modeling of desmoplakin cardiomyopathy dysfunction, which could be rescued using the bromodomain and extra-terminal inhibitor INCB054329.

    • Mark W. Pocock
    • Janice D. Reid
    • James E. Hudson
    ResearchOpen Access
    Nature Cardiovascular Research
    P: 1-20
  • Tissue-resident macrophages (TRM) are important mediators of local immunity. Here the authors show that the deficiency or inhibition of a kinase, WNK1, unlinks macrophage colony-stimulating factor signaling and resulted macropinocytosis with the downstream, potentially IRF8-mediated genetic program to bias progenitor differentiation to neutrophil instead of TRM.

    • Alissa J. Trzeciak
    • Zong-Lin Liu
    • Justin S. A. Perry
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19
  • Low formate dehydrogenase (FDH) activity limits formate assimilation via the synthetic reductive glycine pathway. In this study, the authors introduce a faster FDH in synthetic formatotrophic E. coli, which boosts growth rates and bioproduction titers from formate as sole carbon source.

    • Aidan E. Cowan
    • Mason Hillers
    • Nico J. Claassens
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13
  • Transcription and RNA splicing are tightly coupled in eukaryotic cells. Here, authors report the multivalent interaction between U1 snRNP and the transcription elongation complex which may allow efficient co-transcriptional spliceosome assembly.

    • Luojia Zhang
    • Christopher Batters
    • Suyang Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-10
  • The estimation of low energies of many-body systems is a cornerstone of the computational quantum sciences. This paper demonstrates on a superconducting quantum processor that the Krylov quantum diagonalization algorithm is poised to complement its classical counterparts at the foundation of computational methods for quantum systems.

    • Nobuyuki Yoshioka
    • Mirko Amico
    • Antonio Mezzacapo
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-8
  • Cluster states are a key resource in quantum technologies, but generation of large-scale 2D cluster states faces several difficulties. Here, the authors show how to generate a 2 Ã— n ladder-like cluster state via sequential emission of time- and frequency multiplexed photonic qubits from a transmon-based device.

    • James O’Sullivan
    • Kevin Reuer
    • Andreas Wallraff
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-7
  • Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) is important for invasion of reticulocytes and PvRBP2b antibodies correlate with protection. Here, Chan et al. isolate and characterize anti-PvRBP2b human monoclonal antibodies and describe mechanisms by which these antibodies inhibit invasion.

    • Li-Jin Chan
    • Anugraha Gandhirajan
    • Wai-Hong Tham
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14
  • Castleman disease encompasses a group of disorders characterised by abnormal lymph node morphology. Here the authors use single cell and spatial transcriptomics to assess the stromal, immune and interaction architecture of different subtypes of Castleman disease, indicating potential ligand-receptor interactions between immune cells.

    • David Smith
    • Anna Eichinger
    • Vinodh Pillai
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14
  • Peptidoglycan fragments derived from gut bacteria modulate aspects of the host’s health. Here, Li et al. profile peptidoglycan fragments in the host gut and show that one of them, the disaccharide GlcNAc-MurNAc, acts as a mild TLR4 agonist and protects against gut inflammation.

    • Chenyu Li
    • Christopher Adamson
    • Yuan Qiao
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17
  • Natural forest regeneration is key to biodiversity conservation and climate change mitigation. Here the authors present a high-resolution time-series map of the age of regenerating tropical moist forests and find that most are ≤5 years old, with forest characteristics and geography explaining patterns better than climate or human pressure.

    • Christopher G. Bousfield
    • David P. Edwards
    ResearchOpen Access
    Nature Ecology & Evolution
    P: 1-9
  • Malonyl-CoA (M-CoA) is essential for polyketide biosynthesis, but its limited availability constrains production. Here the authors engineer and evolve an orthogonal M-CoA pathway in Escherichia coli to improve M-CoA metabolism, increasing M-CoA levels and polyketide yields.

    • Sarah H. Klass
    • Mia Wesselkamper
    • Jay D. Keasling
    ResearchOpen Access
    Nature Chemical Biology
    P: 1-12
  • Interlocked molecules offer a platform to control the relative motion between different molecular components with precision which is a cornerstone of synthetic nanotechnology. Here, the authors utilize a molecular dual pump to achieve the assembly of translational isomers with high efficiency and accuracy.

    • Christopher K. Lee
    • Jake P. Violi
    • Dong Jun Kim
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-8
  • An expert-elicitation process identifies current methodological barriers for monitoring terrestrial biodiversity, and how technological and procedural development of robotic and autonomous systems may contribute to overcoming these challenges.

    • Stephen Pringle
    • Martin Dallimer
    • Zoe G. Davies
    ResearchOpen Access
    Nature Ecology & Evolution
    Volume: 9, P: 1031-1042
  • Genomic analyses of DNA from modern individuals show that, about 800 years ago, pre-European contact occurred between Polynesian individuals and Native American individuals from near present-day Colombia, while remote Pacific islands were still being settled.

    • Alexander G. Ioannidis
    • Javier Blanco-Portillo
    • Andrés Moreno-Estrada
    Research
    Nature
    Volume: 583, P: 572-577
  • Light gated reactions are important due to their spatial and temporal control over the chemical processes but long wavelength activation of photocycloaddition reactions are rare. Here the authors introduce a green light induced [2+2] cycloaddition of a halochromic system, which allows for its photo-reactivity to be switched on and off by adjusting the pH of the system.

    • Kubra Kalayci
    • Hendrik Frisch
    • Christopher Barner-Kowollik
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-8
  • Green spaces are known to help cool cities, but they contribute humidity while reducing heat—and both matter. Using smart sensors mounted on bicycles, this study finds that daytime temperature reductions in urban green spaces are largely offset by humidity increases but that urban vegetation causes a net reduction in humid heat at night.

    • Yichen Yang
    • Chang Cao
    • Xuhui Lee
    Research
    Nature Cities
    Volume: 1, P: 871-879
  • The replicative helicase CMG is targeted for removal or proteolysis by the E3 ubiquitin ligase TRAIP. This study describes how the de-ubiquitylating enzyme USP37 protects genome stability by preventing premature TRAIP-dependent CMG unloading when replication stress impedes timely termination.

    • Olga V. Kochenova
    • Giuseppina D’Alessandro
    • Stephen P. Jackson
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17
  • How lung epithelial and endothelial cells develop into alveoli is a major knowledge gap, with implications for lung repair in preterm infants. Here, the authors establish a transcriptomic atlas of human neonatal lung disease, identifying semaphorins as pivotal mediators of organogenesis and injury.

    • Shawyon P. Shirazi
    • Nicholas M. Negretti
    • Jennifer M. S. Sucre
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14
  • Noel et al. show aberrant updating of expectations in three distinct mouse models of autism spectrum disorder. Brain-wide neurophysiology data suggest this stems from excess units encoding deviations from prior mean and a lack of sensory prediction errors in frontal areas.

    • Jean-Paul Noel
    • Edoardo Balzani
    • Dora E. Angelaki
    Research
    Nature Neuroscience
    P: 1-14
  • This study employs a citizen science approach to identify and classify over 230,000 light sources in German city centers, suburbs and villages. The results underscore the pivotal role of citizen science in expanding knowledge of artificial light emissions and bolstering policymaking efforts to mitigate urban light pollution.

    • Team Nachtlichter
    • Achim Tegeler
    • YiÄŸit Öner AltıntaÅŸ
    ResearchOpen Access
    Nature Cities
    Volume: 2, P: 496-505
  • This study investigates the role of 3,4-dihydroxyphenylacetaldehyde synthase (DHPAAS) in mosquito cuticle formation, a key factor in their development and survival. The findings reveal that DHPAAS is essential for abdominal integrity and egg development, with unique structural features suggesting a novel oxygen delivery mechanism.

    • Jing Chen
    • Christopher J. Vavricka
    • Qian Han
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13
  • The activity of the membrane-bound enzyme pMMO depends on copper but the ___location of the copper centers is still under debate. Here, the authors reconstitute pMMO in nanodiscs and use native top-down MS to localize its copper centers, providing insights into which sites are essential for activity.

    • Soo Y. Ro
    • Luis F. Schachner
    • Amy C. Rosenzweig
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12
  • The underlying mechanism of electroconvulsive therapy remains not fully understood. Here, the authors use optical neuroimaging in mice and humans to show that electroconvulsive therapy elicits a second brain event after seizure—spreading depolarization—a previously hidden phenomenon that may help to understand and optimize this treatment.

    • Zachary P. Rosenthal
    • Joseph B. Majeski
    • Ethan M. Goldberg
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14
  • Fluorogenic RNA aptamers such as Mango are powerful tools for RNA imaging. An ultrabright RNA-activated fluorophore with improved photophysical performance has now been developed using a structure-informed, fragment-based screening approach. This system was studied using high-resolution crystallography and applied to image RNA in cells.

    • Mo Yang
    • Peri R. Prestwood
    • John S. Schneekloth Jr
    Research
    Nature Chemistry
    P: 1-8
  • Genome-wide analyses identify 30 independent loci associated with obsessive–compulsive disorder, highlighting genetic overlap with other psychiatric disorders and implicating putative effector genes and cell types contributing to its etiology.

    • Nora I. Strom
    • Zachary F. Gerring
    • Manuel Mattheisen
    ResearchOpen Access
    Nature Genetics
    Volume: 57, P: 1389-1401
  • APOBEC mutational signatures are commonly found in multiple cancer types. Here, the authors utilize multi-omics analyses to reveal that the cooccurrence of APOBEC associated mutagenesis and tobacco-smoking-related mutations affects lung tumor evolution and age at onset of lung cancer from smokers.

    • Tongwu Zhang
    • Jian Sang
    • Maria Teresa Landi
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17
  • Weak perturbations couple solitons—nonlinear pulses—to low-amplitude linear waves. Longstanding mathematical results indicate that this phenomenon is universal. The authors verify these predictions experimentally by demonstrating that the coupling amplitude satisfies a general scaling law.

    • Justin Widjaja
    • Y. Long Qiang
    • C. Martijn de Sterke
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-8