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The authors propose a design that equips a programmable metasurface with integrated capability for sensing and manipulating electromagnetic waves, allowing it to leverage the environmental information to enhance wireless system performance in complex environments.

R9AP is a key receptor for entry of Epstein–Barr virus into human epithelial and B cells, and interacts directly with the viral glycoprotein gH/gL complex to mediate virus–host membrane fusion.

This study presents an optical cloud computing system that enables long-distance, high-speed AI processing and communication with low power consumption. The approach offers a scalable and secure alternative to electronic cloud computing, addressing key energy and privacy challenges.

It has long been believed that topological phases are solely determined by their lattice structures. Here, the authors report the observation of cavity-tunable topological phases of polaritons by modifying the surrounding photonic environment without altering the lattice structure.

DNA Damage Regulated Autophagy Modulator 1 (DRAM1) plays pivotal roles in autophagy regulation. Here, the authors show that DRAM1 stabilizes lysosomal VAMP8, thereby promoting autolysosome maturation. Furthermore, they establish that DRAM1–VAMP8 axis enhances autophagic flux and facilitates hepatocellular carcinoma extravasation, as validated in both zebrafish xenograft and mouse metastatic models.

Chen et al. use UK Biobank data to reveal a dietary pattern associated with a lower risk of dementia, and validate this in additional cohorts.

Using two cohorts, Liu, Ge, Xiao, Lu and colleagues perform plasma metabolomics and lipidomics, linking reduced sarcosine to sarcopenia diagnosis. In mice, they demonstrate that sarcosine enhances muscle repair, boosts adipose thermogenesis and preserves muscle mass via macrophage modulation.

Epithelial malfunction is an unmet critical challenge in trachea repair. Here, Chen et al. developed a multiplexed hydrogel to promote tracheal repair with native-like epithelium in pre-clinical models, exhibiting clinical translation potential.

Ferroptosis immunotherapy is promising for treating triple-negative breast cancer, but hindered by limited iron levels in tumor cells and a lack of specific immune responses. Here, the authors report a biohybrid system that enhances iron level by activating endogenous iron ions and replenishing exogenous iron ions and targets ferritin for synergistic ferroptosis immunotherapy.

Glia–neuron interactions are highly complex. Glial cells can sense and modulate different aspects of neuronal activity. Here in Caenorhabditis elegans, the authors show that early aged sensory neurons can transfer proteins via extracellular vesicles to AMsh glia, inducing neuroprotection during aging.

The authors provide insight into fundamental mechanisms of gene regulation that carries therapeutic implications for Prader-Willi syndrome and a model for maintenance of the PWS imprinted ___domain.

A versatile nano-adaptor is used to construct multi-specific nano-antibodies for treatment of tumours in mice.

While Bell inequalities have been violated several times—mostly in photonic systems—their violations within particle physics experiments are less explored. Here, the BESIII Collaboration showcases Bell-violating nonlocal correlations between entangled hyperon pairs.

The performance of perovskite-based tandem solar cells is hindered by the desorption of the molecules that passivate detrimental defects. Now, researchers design passivators with multiple functional groups and a strong dipole to strengthen the binding to the perovskite, enhancing the efficiency and photothermal stability of perovskite/copper indium gallium selenide (CIGS) tandem cells.

Structural vacancies in crystalline solids have potential in tuning optoelectronic properties. However, the random distribution of vacancies a problem when creating materials with completely reproducible functions. Here authors use vacancy engineering to improve electronic communication between cluster units in 3D orientationally ordered MOF crystals.

Patients with gastric cancer often present with poor performance status, limiting both quality of life but also treatment options as they are often excluded from clinical trials. Here, the authors report a phase II trial investigating anlotinib (multi-TKI) plus toripalimab (anti-PD-L1 monoclonal antibody) in treatment-naïve advanced gastric cancer patients with performance status 2.

Single-cell data analysis is challenging due to inherent noise and sparsity. Here, authors introduce scMINER, a mutual information-based integrative tool to enhance clustering and reveal regulatory networks and hidden biological drivers by transforming scRNA-seq expression into activity profiles.

Dysregulated R-loops can compromise genome stability, leading to pathological consequences. Li et al. demonstrate that R-loop-induced poly(ADP-ribose) polymerase 1 activation orchestrates exonuclease 3′–5′ ___domain-containing 2-mediated R-loop resolution, thereby safeguarding genomic integrity.

The rational design of diatomic catalysts faces challenges due to the numerous tunable parameters. Here, the authors report a geometric-electronic coupled design using machine learning-derived catalytic “hot spot maps” for screening diatomic catalysts towards oxygen reduction reaction.

The H9N2 avian influenza viruses (AIVs) remain dominant in live poultry markets in China, and H9N2 AIVs with HA-Q226L, PB2-V/K627 and NP-N52 mutations can be transmitted between guinea pigs and between ferrets via direct contact and respiratory droplet.

The precise synthesis of functional polyarylamines based on a reactivity-regulated sequent cross-coupling carbon–nitrogen polycondensation method has been reported, with excellent batch-to-batch uniformity for perovskite solar cells.

The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.

Cyclic dimeric adenosine monophosphate is found to be a second messenger in eukaryotic cells that is generated by adenylate cyclase 7 and connects Toll-like receptor 9 stimulation to nucleotide-binding ___domain, leucine-rich repeat protein 3 inflammasome activation.

First-instar orchid mantis nymphs avoid predators by mimicking black-red assassin bugs, whereas those in later instars avoid predators and attract prey by camouflaging themselves as lighter-coloured flowers. Here the authors use developmental transcriptomics, evolutionary genomics and predation experiments to reveal that this ontogenetic colour change is regulated by a pigment transporter called Redboy that emerged in Polyneoptera 284–197 million years ago.

The authors describe a new mechanism of AD pathogenesis in which the histone methylase G9a regulates translation of hippocampal proteins associated with AD pathology. Targeting this mechanism with a brain-penetrant inhibitor of G9a helped rescue brain pathology in AD mouse models.

Holmium doping endows upconversion nanoparticles with a dual-reservoir-level mechanism for parallel photon avalanche emission, enabling tunable chromaticity at room temperature, nonlinearity index up to 22 and spatial resolution for multicolour biological imaging down to 78 nm.

Currently, there is an urgent need to evaluate the strengths and limitations of various probe-based full transcriptome methods for formalin-fixed paraffin-embedded tumor tissues. Here, the authors analyze three commonly used methods and highlight relative advantages and disadvantages of each method in the context of operational challenges, bioinformatic analyses and biological discoveries.

Detecting small molecules is pivotal across many fields. Here, authors leverage a split crRNA mode to construct spatially blocked split CRISPR-Cas12a system. This approach establishes a low-background, highly sensitive platform for small molecule detection.

External stimulus-induced cellular stress response plays a role in the development of esophageal squamous cell carcinoma (ESCC). Here the authors show that stress-induced activation of p38 MAPK leads to ACSL4 phosphorylation and Src myristoylation to promote tumorigenesis in ESCC.

The impacts of alpine grassland restoration on microbial community stability and its relationship with the plant-soil system are unclear. Here, using co-occurrence network analysis, the authors find that core microbes contribute to plant-soil resilience.

Clusters have proven useful models to elucidate the correlation between macroscopic properties and microstructures, but the exploration of actinide clusters lags. Here, the authors report the synthesis of a tetra-shell mixed-metal cluster which features a Th₁₃ core and acts as a highly effective visible light-driven CO₂ reduction photocatalyst.

Alpine plants exhibit phenological adaptations to germinate and complete their reproductive cycles during the most favorable growing seasons. Here, the authors show that allelic variation in the GA20ox3 gene is crucial for the adaptability of fruit length and seed germination timing in high-altitude ecotypes of A. thaliana.

Atrial fibrillation is a prevalent and serious arrhythmia associated with increased morbidity and mortality worldwide. Here the authors show a contactless, operation-free, and device-free AF detection framework utilizing artificial intelligence-powered radio technology, achieving performance comparable to conventional ECG-based methods.

Enhancing the arsenal of E3 ligases is important for PROTACs development. Here, the authors identify a non-inhibitory aptameric ligand to CRL2^ZYG11B E3 ligase, and develop a general, modular, and straightforward aptamer-based PROTAC platform, termed ZATAC, providing insights for untapped E3 ligases.

The formation of organelles was a pivotal point in eukaryotic evolution. Here they show that Archaea possess Arf-like GTPases that can perform key organelle-producing mechanisms when expressed in a eukaryotic cell, laying the foundation for the evolution of endomembrane organelles.

Conventional stretchable circuit fabrication requires complex packaging to prevent leakage. Here the authors introduce a self packaging stretchable circuit enabled by in situ sintering of ligand-bound liquid metal particles, allowing scalable, leakage-free, multilayer integration.

Here, the authors report the experimental realization of a 3D Wannier-type photonic HOTI, which hosts coexisting self-guided topological surface, hinge, and corner states in a single 3D tight binding-like photonic crystal.

A novel covalent inhibitor, ISM3312, targets the main protease of multiple human coronaviruses, including drug-resistant strains, and shows broad antiviral activity. It offers a promising therapeutic strategy against current and future coronavirus threats.

In the IMpower151 trial, the drug combination previously shown to be effective in the IMpower150 trial was not significantly effective in a Chinese population.

Bamboo’s native structure, defined by the vertical growth pattern of its vascular bundles and parenchyma cell tissue, limits its application in advanced engineering materials. Here the authors show a method that controls localized moisture content to shape natural bamboo into a versatile three-dimensional structural product.

H₂O₂ is a commodity chemical produced in industry via the anthraquinone process from H₂ and O₂. Now a heterogeneous catalysis approach is presented in which H₂O₂ is synthesized from H₂O and O₂ on defective SnSe nanosheets at ambient conditions.

In this work, Dong and coworkers report a set of benzo[f]quinoline-linked covalent organic frameworks via a one-pot three-component [4 + 2] cyclic condensation reaction which are used as photocatalysts for H₂O₂ production in pure water.

The genomic epidemiology of Acinetobacter baumannii, which is rising in virulence and multidrug resistance, was explored. This study examined bloodstream infection isolates from Chinese patients in 2011–2021, revealing increased genetic diversity and dominance of highly virulent ST208.

Chen, Yang et al. present DreAM, the drug-elicitable alternative splicing module, which is responsive to risdiplam, to inducibly regulate adeno-associated virus vector-mediated transgene expression. Proof-of-concept applications in cardiomyocytes revealed its potential for future clinical use in improving cardiac recovery after myocardial infarction.