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High-performance THz electromagnetic shielding is demonstrated using 2D β₁₂-borophene nanosheets embedded in a polymer matrix. At a low loading of 0.1 wt.%, the composite has excellent shielding effectiveness and good mechanical properties.

Combining antibody drug conjugates (ADCs) and tyrosine kinase inhibitors (TKIs) targeting HER2 has been shown to improve efficacy in patients with advanced HER2+ breast cancer. Here, the authors report a randomised phase 2b trial comparing neoadjuvant ARX788 (HER2 ADC) plus pyrotinib (HER1, HER2 and HER4 TKI) against neoadjuvant standard of care (docetaxel, carboplatin, trastuzumab, and pertuzumab) for the treatment of HER2+ breast cancer.

Human NPCs show promise for stroke treatment, but challenges remain in neuron diversity and maturation time. Here, the authors describe the generation of FOXG1 progenitors from iPSCs that quickly mature into functional cortical neurons, enhancing stroke recovery in rats.

Corticosteroids shorten organ dysfunction in sepsis and related illnesses, but their risks and benefits remain unclear. Here, the authors show that machine learning-based trajectory prediction can reveal how corticosteroid effects vary by patient profile.

Topological polar textures in moiré ferroelectrics have been theoretically predicted but lacked experimental confirmation. Here, the authors observe alternating out-of-plane polarization in ___domain regions and vortex-like inplane polarization patterns at ___domain wall boundaries, indicative of a network of merons and antimerons.

Sweat sensors are important in personalized healthcare using natural oxidase to target biomolecules but these reactions are susceptible to external interference. Here, the authors report tryptophan- and histidine-treated copper metal-organic frameworks which show highly selective activity for ascorbate oxidation and can serve as an efficient ascorbate oxidase-mimicking material in sensitive sweat sensors.

Xiao, Dong, Xie, Feng et al. developed FRα-targeting chimeras (FRTACs) for targeted membrane protein degradation by conjugating multiple folate molecules to antibodies of targeted proteins. The folate polyvalency of FRTACs enables high affinity and potency of FRTACs in eliminating target proteins.

The Dark sectioning algorithm removes the background and provides single-frame optical sectioning in fluorescence microscopy. It offers improved quantitative analysis and deep-tissue segmentation accuracy and is compatible to diverse modalities.

Rajachandran, Xu, and colleagues present PHOTON, a subcellular resolution spatial transcriptomics technology that allows the capturing of RNA information within various subcellular compartments under the native cellular context.

RNA assembly has potential for developing biomaterials with tailored properties and functionalities. Here, the authors report on designed, angle-controllable RNA tiles for programmable 1D and 2D self-assembly of RNA, demonstrating RNA sensing and expanding the library of synthetic RNA nanostructures.

The global regulator PhoP plays crucial roles in bacterial pathogenicity. Shi et al. report four cryo-EM structures of PhoP-dependent transcription activation and repression complexes, revealing dual transcription regulation mechanisms of PhoP.

Two genetically linked TdNLR genes from wild emmer wheat are both required for YrTD121-mediated stripe rust resistance. The TdNLR1 and TdNLR2 pair lacks an integrated ___domain, representing an uncommon architecture for paired NLRs in plants.

Enantioselective NH transfer that allows concise assembly of unprotected enantioenriched amines remains a challenge. Here, the authors report an iron-catalysed stereoselective NH imidation of sulfoxide, which is integrated with photocatalytic racemisation of sulfoxide, enabling a dynamic kinetic resolution strategy for direct and asymmetric synthesis of NH-sulfoximines.

Guided by a structure of VGLUT2 with substrate, Li et al. identify the mechanisms for selective substrate recognition, a role for lipid modification in limiting axonal dispersion and for the cytoplasmic gate in allosteric regulation by lumenal H⁺.

Bipyridyl herbicides (BPyHs) can be absorbed and inactivated by negatively charged soil after application. Here, the authors overcome the problem by applying BPyHs with the positively charged polymer cationic polyacrylamide and engineer BPyHs-resistant rice line for efficient weed control in field conditions.

The amphiphilic low-molecular-weight protein hydrophobin (HFBI) can self-assemble into a crystalline monolayer film. Here, the authors present a cryo-EM support film using such 2D crystals of hydrophobin HFBI and show that it protects specimen from the air-water interface and can help to overcome the preferred orientation problem of particles in cryo-EM.

Polar skyrmions are a topological polarization texture. While they have now been detected in numerous material systems, near universally these have required careful strain engineering. Here, Xue, Zhang, Zheng, Tong, Wang and coauthors observe polar skyrmions in the van der Waals ferroelectric CuInP2S6, without strain-engineering.

The authors demonstrate the role and mechanism of triacylglycerol (TAG) cycling in polyunsaturated fatty acid biosynthesis and develop a strategy of decoupling the TAG biosynthesis and degradation to improve related biochemical synthesis.

How signaling pathways recruit SWI/SNF chromatin remodeling complexes is not known. Here the authors suggest a ubiquitin directed mechanism targeting SWI/SNF for Wnt pathway dependent transcription, important for development and cancer.

TPP endows TPP₃Cu₂Br₂ with both excellent water resistance and sensitive temperature-dependent luminescence lifetime, achieving a S_r up to 12.82% K⁻¹.

This study shows how auditory cortex activation and cognitive function develop during a six-month follow-up after gene therapy in children with congenital deafness.

The 2015–2016 Zika virus outbreak in the Americas was characterised by high numbers of cases in women of reproductive age, but the extent to which this reflected surveillance bias is unclear. Here, the authors develop a statistical model which adjusts for surveillance bias and use it to estimate transmission risks in different groups using data from Colombia.

Preclinical studies have shown synergy in the combination of tifcemalimab (anti-BTLA antibody) with toripalimab (anti-PD-1 antibody) in lymphoma. Here, the authors report a clinical trial investigating tifcemalimab alone and in combination with toripalimab in patients with relapsed or refractory lymphoma.

Socioeconomic status is multidimensional and can change over time. Xu, Lui, Ji et al. found dimension-specific, late-stage-specific and change-specific socioeconomic effects on brain, cognition, personality and emotion.

Worldwide, the number of only-child families is increasing. This research examines how growing up without siblings affects adult brain structure, function and connectivity, cognition, personality and mental health.

Global potential forestation could provide about 0.06 °C of biophysical cooling, yet this benefit is expected to diminish as atmospheric CO₂ increases, primarily because background climate shifts weaken the non-local cooling mechanisms.

Foundation models enable rapid adaptation to various downstream tasks and are hence about to become a new paradigm in biomedicine. Here, the authors develop LLaVA-Rad, a small AI that bests larger models in chest X-ray interpretation, and CheXprompt, a radiologist-aligned factuality metric, to enable scalable, privacy-preserving image analysis.

Light-emitting diodes with suppressed efficiency roll-off can be created by intercalating oxygen plasma into few-layer molybdenum disulfide and tungsten disulfide.

The immune response of immunotherapy in colorectal cancer remains low and new adjuvant targets are in demand. By in vivo CRISPR-Cas9 screening that targets membrane and secreted proteins genes, the authors identify that disrupting MBTPS1 in tumor cells upregulates STAT1-transcribed chemokines, promotes CXCR3⁺ CD8 T cells infiltration and potentiates anti-PD-1 therapy.

Response to cancer therapeutics is heterogenous making it hard predict despite advances in machine learning approaches. Here, the authors develop a graph neural network-based approach, Graph-Encoded Mixture Survival (GEMS), to identify ‘predictive subphenotypes’ of patients with similar baseline characteristics and survival outcomes of cancer patients using electronic health records to predict patient response to therapy.

The authors develop a transparent ultrasonic transducer using Pb(In_1/2Nb_1/2)O₃- Pb(Mg_1/3Nb_2/3)O₃-PbTiO₃ crystals, achieving enhanced sensitivity and bandwidth for photoacoustic microscopic imaging. This advancement enables dynamic microvascular monitoring, enhancing applications in brain research.

Researchers present the evidence and mechanism of distinct phase transformation pathways in MAX phases under ion irradiation, providing a new theory and predictive method for phase behavior based on composition, advancing understanding of materials in extreme conditions.

The influence of pregnancy on Long COVID is not well understood. Here, the authors use electronic health record data from the United States to compare the incidence of Long COVID in females after infection in pregnancy with matched non-pregnant females of reproductive age.

The apelin receptor (APJR) is a drug target for cardiovascular and metabolic health. Here, authors reveal how ligand binding, receptor dimerization, and G protein coupling cooperate to regulate APJR signaling pathway, providing insight for drug discovery.

The magnetic field effect of ferromagnetic spin electrocatalysts to enhance catalytic activity under external magnetic fields brings promises and challenges. Here, the authors report the ferromagnetic Fe-TiO₂ to investigate magnetic field effect on electrocatalytic reduction of nitrate for ammonia.

The authors utilize the pulsed electric stimulus near the critical electric field to perform the antiferroelectric-ferroelectric phase transition engineering, realizing enhancement and quick stabilization of capacitance in antiferroelectrics.

A quantum microsatellite, with a payload weighing only 23 kilograms, in combination with portable ground stations that weigh merely 100 kilograms, is capable of performing space-to-ground real-time quantum key distribution.

Epsilon Fe2C is considered a promising catalyst for syngas conversion due to its inherently low CO2 selectivity, but its application is limited by poor high-temperature stability. Here the authors present a successful method for synthesizing highly stable ε-Fe2C using a nitrogen-induced strategy through the pyrolysis of Prussian blue analogs.

Catalytic asymmetric click reactions of azides and alkynes for chiral triazole synthesis remains a challenge, due to the limited catalytic systems and substrate scope. Herein, the authors report the enantioselective azidation/click cascade reaction of N-propargyl-β-ketoamides via copper catalysis, affording a variety of chiral 1,2,3-triazoles.

Qu et al. report a self-assembled material with π-expanded conjugation to form hydrophilic ordered bilayer as hole selective layer for inverted perovskite solar cells. The enhanced interfacial charge extraction and transport enable certified efficiency of 26.39% and 25.21% for 7.15 mm² - and 99.12 mm² -devices, respectively.

Pan-genome analysis of 24 alfalfa accessions identifies key structural variations associated with salt tolerance and quality traits and provides resources for genomics-assisted breeding in alfalfa.