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LepR⁺ cells senescence is a driver of aging-induced bone marrow homeostasis collapse. Here, Li et al. report a LepR⁺ cell-targeting nitric oxide (NO) nanopump for rejuvenation of senescent LepR⁺ cells via activation of glycolysis signaling to reestablish homeostasis of the aged bone marrow.

The transcription factor CREM is a pivotal regulator of NK cell function, making CREM a valuable target to increase the efficacy of anticancer immunotherapies based on this cell population and chimeric antigen receptors.

While Bell inequalities have been violated several times—mostly in photonic systems—their violations within particle physics experiments are less explored. Here, the BESIII Collaboration showcases Bell-violating nonlocal correlations between entangled hyperon pairs.

The mechanism of HIV-1 latency reversal remains unclear. The authors suggest that PRMT3 drives the reversal by enhancing chromatin accessibility to form a transcriptional hub containing TEAD4 and P-TEFb at the viral promoter.

While CDK4/6 inhibitors have become standard of care in patients with HR+/HER2- advanced breast cancer (ABC), selecting the optimal inhibitor could improve care further. Here, the authors report planned interim analysis of the BRIGHT-2 study, a randomised phase 3 trial comparing bireociclib (CDK4/6i) and fulvestrant (ET) against placebo and fulvestrant in female HR + /HER2- ABC patients.

Heterogeneous single-atom catalysts (SACs) offer high atom utilization and well-defined active sites but face challenges in multi-stage cross-couplings due to limited coordination and reactivity. Here, the authors introduce SACs on reducible carriers, enabling adaptive coordination to bypass oxidative addition in cross-couplings.

This study reports the horizontal gene transfer of CSP genes from bacteria to Triticeae, promoting the adaptation and spread of wheat through enhanced drought tolerance and photosynthetic efficiency.

The authors show cryo-electron microscopy structures of the human high-affinity sodium–dicarboxylate cotransporter, responsible for dicarboxylate import into the cell, in complex with various substrates and in different states establish the basis of substrate recognition, differentiation and release, as well as regulation of transport ___domain movement.

Electrocatalytic reduction of CO₂ over copper can be made highly selective by ‘tuning’ the copper surface with adsorbed organic molecules to stabilize intermediates for carbon-based fuels such as ethylene

PinMyMetal (PMM) is an accurate tool for predicting transition metal binding sites in proteins. It integrates geometric and chemical features, outperforms existing methods, and supports large-scale genome analysis and drug design.

The cyclopiane diterpenoids are a class of complex natural products with unique carbon skeleton and diverse biological activities. Herein, the authors report the total synthesis and chemical proteomics studies of cyclopiane diterpenes which culminate in the asymmetric total synthesis of conidiogenones C, K and 12β-hydroxy conidiogenone C, and identification of Immunity-related GTPase family M protein 1 as a cellular target of conidiogenone C.

How intracellular iron homeostasis is controlled and regulated is not well understood. Here, the authors show that SLC39A13 promotes iron transport from the cytosol to the ER/Golgi and affects iron metabolism in several compartments.

In β-thalassemia, decreased β-globin synthesis leads to red blood cell loss, iron overload and anemia. Using a mouse model of this disease, Huihui Li et al. now describe a new approach for treating β-thalassemia: injection of the iron transporter transferrin. This therapy had many beneficial effects, including reversing splenomegaly and raising red blood cell counts.

The semileptonic decay channels of the Λc baryon can give important insights into weak interaction, but decay into a neutron, positron and electron neutrino has not been reported so far, due to difficulties in the final products’ identification. Here, the BESIII Collaboration reports its observation in e+e- collision data, exploiting machine-learning-based identification techniques.

Respiratory virus infection often induces excessive cytokine and chemokine production. Here the authors show in vitro that infection by the enterovirus, EV-D68, induces CXCL8/CXCR1/2 signaling and translocation of host factor, hnRNP-K, to the cytoplasm as a means to facilitate viral replication.

Small transporters pose a challenge for cryo-EM structure elucidation. Here, the authors tackled this limitation by rigidly fusing a fiducial marker to a transporter C-terminus, enabling multiple structures to be elucidated from a single sample.

SsPEIE1 is an essential virulence factor of Sclerotinia sclerotiorum. SsPEIE1 interacts with the key immune factor AtHIR4 and inhibits AtHIR4 oligomerization-mediated immune responses in Arabidopsis, thereby promoting S. sclerotiorum infection.

The good adhesion of scales is crucial for safe service of alloys. This study reveals that trace sulfur impurities can cause severe interface segregation and premature cracking, and such a detrimental effect can be prevented by micro alloying.

As single-molecule localization microscopy (SMLM) achieves higher precision, linkage errors from antibody labeling increasingly hinder imaging accuracy. Here, the authors employ MINFLUX to analyze linkage error distributions across various antibody labeling strategies, revealing deviations from normality and suggesting statistical methods to enhance SMLM accuracy, with implications for super-resolution imaging advancements.

Efficient and stable catalysts for oxygen reduction reactions are difficult to achieve due to slow kinetics and degradation. Here, the authors use a ‘carbon defect anchoring’ strategy to create Pt₁Ni₁@Pt core-shell nanoparticles with high activity and durability.

Peesh et al. show that ischemic stroke reduces microbiota-derived and increases host-derived aryl (AHR) hydrocarbon ligands. Post-stroke treatment with indole-based AHR ligands improved microglia-mediated antigen processing and co-stimulatory immune functions.

A 2D Czochralski method is introduced for rapidly growing centimetre-scale single-crystal MoS₂ domains with low defect density and impressive electrical performance. This method shows potential for fabricating high-quality and scalable 2D semiconductor materials and devices.

An ongoing effort aims to transform the clonally propagated tetraploid potato to a seed-propagated diploid crop, but our understanding of it disomic inheritance is limited. Here, the authors report genetic basis of heterosis in the elite hybrid potato and identify a male fertility-related PME gene with dominance heterotic effect.

Investigating the inner structure of baryons is important to further our understanding of the strong interaction. Here, the BESIII Collaboration extracts the absolute value of the ratio of the electric to magnetic form factors and its relative phase for e + e − → J/ψ → ΛΣ decays, enhancing the signal thanks to the vacuum polarisation effect at the J/ψ peak.

Wafer-scale two-dimensional transition metal selenides, with high structural quality and environmental stability, can be obtained by two-step vapour deposition in oxygen-free conditions. The grown films maintain robust superconductivity even after harsh treatments.

Transition metal complexes are potential low-cost electrocatalysts for CO₂ reduction. Here, using accessible spectrochemistry, the authors observe an intriguing baton relay-like mechanism of active site transfer during CO₂ reduction to CO on a carbon-supported copper bis-(terpyridine) complex.

Healthy T cells are polyclonal, while malignant T cells are developing via clonal expansion. Here authors show that T cell tumours could be eradicated by chimeric antigen receptor T cells targeting the T cell receptor (TCR) β-chain that is specific to malignant T cells, while healthy T cells using diverse TCR β-chains are spared.

Thrombosis and inflammation coexist in many diseases, however, there is lack of treatments targeting both pathologies. This study reports a novel antibody against blood factor XII, which bears a promise to treat broad thrombo-inflammatory disorder.

A comprehensive variation map constructed by deep sequencing 1,904 accessions of weedy and cultivated broomcorn millet sheds light on the genetic architecture of agronomic traits during domestication.

The lack of large-scale QTL cloning method hampers systematic dissection of genetic base of quantitative traits. Here, the authors develop a multi-omics data-based technique for large-scale and rapid cloning of quantitative genes of tassel branch number and discovery of selection signatures in maize breeding.

Here, the authors identify key DNA methylation sites associated with incident acute coronary syndrome (ACS), improving ACS prediction and highlighting potential biomarkers and therapeutic targets for ACS.

Influenza virus uses metabotropic glutamate receptor 2 (mGluR2) as an endocytic receptor to enter cells through clathrin-mediated endocytosis.

A versatile hydrothermal approach in an operando acidic environment created ferromagnetic single-atom spin catalysts (SASCs). Ni-based SASC exhibits a giant magnetic field enhancement of OER activity, boosting both water and saline water electrolysis.

Multiplexed spiking data coding schemes could enable artificial visual neurons to emulate the human visual system in a more biologically plausible way. Here, Li et al. present an artificial neuron device capable of encoding visual analog signals into spike trains using multiplexed rate and temporal fusion coding. Reviewer recognition:

Wireless bioelectronics integrates untethered controlled-release, wireless power and communication modules into drug delivery systems (DDSs), enabling dynamic, precise drug dosage and release adjustments and shaping the next generation of DDSs — wirelessly controlled DDSs (Will-DDSs).

Characterization of 22-nucleotide short interfering RNAs in plants finds that they accumulate in response to environmental stress, causing translational repression, inhibition of plant growth and enhanced stress responses.

Powdery mildew is a devastating disease that affects global wheat production. Here, the authors report the cloning of the Aegilops searsii-derived powdery mildew resistance gene Pm57 that encodes a tandem kinase protein.

Melatonin promotes EMT in trophoblast cells via GDF15-mediated activation of the SMAD2/3 pathway and partially induces the expression of GPX4 through GDF15 to enhance oxidative damage resistance in trophoblast cells.

Efflux pumps confer antibiotic resistance by coupling proton import with drug export. In this work, the authors uncover the proton-coupled transport mechanism for the clinically relevant efflux pump NorA from the pathogenic bacterium S. aureus.

The CRISPR–Cas9-mediated generation of germline-transmissible mutations of SHANK3 in cynomolgus macaques (Macaca fascicularis) forms the basis of a non-human-primate model of autism spectrum disorder and Phelan–McDermid syndrome.