Search

Negative regulator of thermotolerance 1 (NAT1) is identified as a negative regulator of thermotolerance in rice through the NAT1–bHLH110–CER1/CER1L module. Modifying NAT1 by targeted gene editing increases wax deposition and enhances thermotolerance in rice.

The implementation of synthetic Abelian gauge fields in quantum simulators can result in chiral edge currents. The impact of non-Abelian gauge fields on chiral dynamics of ultracold atoms is now explored using a momentum-space lattice technique.

Strongly correlated and topological phases of matter can be often described using the tools of quantum field theory. Here the authors report the thermal Hall effect in the antiferromagnetic skyrmion lattice of MnSc₂S₄, revealing transport features that can be attributed to an emergent SU(3) gauge field.

Electronic wound bandages have to balance conformability and wound healing properties. Here, the authors develop a smart patch (iSAFE) using biomaterials with bioelectronics to facilitate permeability with waterproofing. This achieves intelligent wound management with real-time wound monitoring and active therapy.

The development of vertical p-i-n junctions has been hindered by complex fabrication techniques and performance trade-off between responsivity and speed. Here, authors employ WSe₂ thin layers to construct photodiode, reporting responsivity of 0.388 A/W and response time down to sub-10 picoseconds.

Disruption of dendritic cell (DC) interstitial motility in the tumour microenvironment promotes immune evasion, and enhancement of DC interstitial motility offers a route for DC-centric immunotherapy.

Data security of internet is increasingly more demanding in the current era, yet the traditional electronic approach is limited in speed and efficiency. Here, the authors proposed a dual-layer optical encryption fluorescent polymer waveguide chip based on optical pulse-code modulation to mitigate the limitations.

CphA1 catalyzes the synthesis of cyanophycin polypeptide consisting of equimolar amounts of aspartate and arginine as a fixed nitrogen reservoir in cyanobacteria. Here, the authors solve the cryo-EM structures of CphA1, revealing the aspartate binding mode and protein dynamics required for cyanophycin elongation.

In this work, authors design novel protein condensation inhibitors (PCIs) targeting an allosteric site of cGAS, blocking DNA interactions and phase separation to suppress immune activation, and demonstrate therapeutic potential in inflammatory disease models.

In optics, schemes have been proposed to realize synthetic gauge fields, but are restricted to the Abelian type. Here, the authors demonstrate synthetic SU(2) non-Abelian gauge fields in anisotropic media, which allows the study of novel optical phenomena not found in Abelian synthetic gauge field systems.

Majorana fermions, particles which are their own antiparticles, are predicted to exist in systems combining superconductivity and topologically non-trivial band structure. Here, the authors propose means to create and manipulate such excitations in one-dimensional chains of adatoms on superconducting surfaces.

Cell-free gene expression (CFE) systems are often constrained by numerous biochemical components required to maintain biocatalytic efficiency. Here, the authors propose a droplet-AI combined approach to perform high-throughput and efficient combinatorial screening of CFE. This work led to simplified CFE systems with improved yield and cost-effectiveness.

The symmetry of free space greatly restricts the properties of quasiparticles that exist in free space. Solid state systems, with the discrete symmetry of the crystal lattice, have far fewer restrictions, and here, Fang et al find a vast array of new quasiparticles, with distinct energy dispersions or external field couplings that can only be realised in the spin-space group.

Quantum phase transitions are governed by Landau-Ginzburg theory and the exceptions are rare. Here, Li et al. propose a type of Landau-forbidden quantum critical points induced by gapless fermions in two-dimensional Dirac semimetals.

The authors describe a new mechanism of AD pathogenesis in which the histone methylase G9a regulates translation of hippocampal proteins associated with AD pathology. Targeting this mechanism with a brain-penetrant inhibitor of G9a helped rescue brain pathology in AD mouse models.

Here the authors described the structure-based design of novel, selective RIPK3 inhibitors that do not induce on-target apoptosis by occupying a unique hydrophobic site and locking RIPK3 into an inactive conformation.

Arousal-modulating neural circuitry remains enigmatic. Here, authors show that the pathway, glutamatergic ventral pallidal neuron→locus coeruleus noradrenergic neuron→the lateral hypothalamus, controls arousal in awake and anesthetized states.

The authors report their observation of the fractional quantum anomalous Hall effect in rhombohedral hexalayer graphene/hBN moiré superlattice devices.

Pulmonary fibrosis is a severe lung disease with limited clinical therapies. Here the authors show that chimeric antigen receptor cells can rescue pulmonary fibrosis in a mouse model, and they further investigate the mechanism of lung regeneration after treatment.

The unique structure and mechanism of chanoclavine synthase (EasC), a haem catalase that uses superoxide for substrate transformation in ergot alkaloid biosynthesis, are revealed in this study, challenging established catalase mechanisms.

ATP/ADP translocators in obligate intracellular parasites and plastids facilitate energy parasitism and endosymbiosis by mediating ATP import and ADP export, with their cryo-EM structures and mechanisms revealed, providing insights for drug development against intracellular pathogens.

The study identifies the L704F mutation in Arabidopsis ABCG36 as a key factor that uncouples the export of the auxin precursor indole-3-butyric acid from the defense compound camalexin. It highlights L704 as a crucial residue in the extracellular gate that influences substrate identity and balances growth-defense trade-offs in the Brassicaceae family.

Climate-driven warming affects the reproduction of oviparous ectotherms. Here, authors identify and characterize a VtgR-mediated heat protection mechanism for oocyte development in both mud crabs and zebrafish.

The dynamical axion quasiparticle, which is directly analogous to the hypothetical fundamental axion particle, is observed in two-dimensional MnBi₂Te₄, and has implications for quantum chromodynamics, cosmology and string theory.

Extreme myopia (EM) is a leading cause of sight impairment caused by progressive retinal degeneration. Here, the authors perform whole-exome sequencing to investigate rare protein-truncating variants among EM cases and identify KDELR3 which contributes to the pathogenesis of EM.

The global monsoon is considered to have provided an important interhemispheric climate link during deglaciation, but direct evidence is lacking. Here, climate evidence from speleothems suggests that rapid latitudinal displacements of the Australasian monsoon play a key role in deglacial warming.

The 1,2 migration reaction on tetracoordinate boron species have been well investigated but less work looked on 1,2-boryl radical shift for the construction of organoborons. Here, the authors demonstrate a visible-light-induced photoredox neutral decarboxylative radical cross-coupling reaction, which undergoes a radical 1,2-boron shift to give a translocated C-radical for further capture of versatile radical acceptors

The genomic and immune landscape of pre-invasive lung adenocarcinoma is poorly understood. Here, the authors perform exome and transcriptome sequencing on precursor legions and invasive lung adenocarcinomas, identifying recurrently mutated genes in pre/minimally invasive cases, and arm level alteration events linked to immune infiltration.

Sun et al. identify a role for PABPC1 in selectively regulating the translation of leukaemogenic mRNAs to promote blast crisis transition, which may be targeted to overcome resistance to TKI treatment in chronic myeloid leukaemia.

Single-photon sources with a single-photon efficiency of 0.60, a single-photon purity of 0.975 and an indistinguishability of 0.975 are demonstrated. This is achieved by fabricating elliptical resonators around site-registered quantum dots.

Genome-wide association studies (GWAS) have improved our understanding of the genetic basis of lung adenocarcinoma but known susceptibility variants explain only a small fraction of the familial risk. Here, the authors perform a two-stage GWAS and report 12 novel genetic loci associated with lung adenocarcinoma in East Asians.

The authors present a photocatalytic method to selectively oxidize glycerol to hydroxypyruvic acid over rubidium–iridium catalytic pairs on poly(heptazine imides) under visible-light illumination.

Rooftop photovoltaic systems are often seen as a niche solution for mitigation but could offer large-scale opportunities. Using multi-source geospatial data and artificial intelligence techniques, the authors map their potential for reducing global temperatures and analyse regional differences.

Existing isokinetic training devices are often heavy, bulky, and energy-consuming, which limits the rehabilitation opportunities only at designated hospitals. Here, the authors show a highly integrated and power-free knee rehabilitation robot that can provide home-based isokinetic training

A superlattice consisting of SrIrO₃ and SrTiO₃ is shown to display a giant response to sub-tesla external magnetic fields—a direct consequence of its antiferromagnetic nature.

This Perspective summarizes the recent progress of topological physics in thermal metamaterials and thus proposes a new research field, ‘topological thermotics’, which is inspired by topological photonics and topological acoustics in wave metamaterials.

The lack of microenvironment understanding results in unsatisfactory conductivity of solid polymer electrolytes. Here, authors report a data-driven exploration of weak coordination manipulation by plasticizer design for safe and energy-dense batteries.

Integrative analyses of transcriptome and whole-genome sequencing data for 1,188 tumours across 27 types of cancer are used to provide a comprehensive catalogue of RNA-level alterations in cancer.

Boson sampling with three, four and five photons with high efficiency, purity and indistinguishability is realized using a quantum dot–micropillar as the single-photon source. A record-breaking sampling rate of 4.96 kHz is achieved.

Discovering active phases in heterocatalysis entails efficient configuration sampling and optimization. Here, the authors developed a framework based on topology and machine learning to effectively explore the active structures, applied in the CO2 electroreduction and Oxygen Reduction Reaction