Search

CO₂ reduction to value-added products is an attractive strategy in sustainable chemistry. Now a photochemical diode simultaneously drives biophotocathodic CO₂-to-multicarbon conversion and photoanodic glycerol oxidation under red light with a photocurrent density of ~1.2 mA cm⁻² and a Faradaic efficiency of ~80%.

The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.

Synaptic adhesion molecules like PTPδ are critical for synapse formation and function. Here authors show PTPδ with mini-exon B regulates excitatory synapses in cell-type-specific and IL1RAP-dependent manners.

Baseline performance, benchmarks, and guidance for LLMs in biomedicine are limited. The authors assess four LLMs on 12 tasks, establish baselines, examine hallucinations, and provide recommendations for optimal LLM use.

This study investigates the Barbatia virescense byssal system and reveals additional function for the EGF protein, known for skin regeneration, as a biological adhesive across diverse species, highlighting its possible roles in wet-adhesion applications.

The chances of detecting fast radio bursts from a galaxy may be affected by its inclination angle, showing a potential selection bias in determining the sources of the bursts.

Preclinical studies for amyotrophic lateral sclerosis are challenging. Here, the authors propose a device mounted on the skin of animals that mitigates electromyography signal contamination and offers high precision in monitoring drug effects on dysphagia-responsible bulbar muscles.

Sensing internal body states is crucial for physiological homeostasis. Here, the authors show that the C. elegans PIEZO channel regulates swallowing by detecting intestinal food buildup and triggering pharyngeal movements to aid ingestion.

Benefits of breastfeeding are well established, but a comprehensive study about its impacts on hospitalizations is lacking. Here, the authors use Korean nationwide birth cohort data (n = 1,608,540) and find that breastfeeding for at least 6 months was associated with a lower risk for subsequent hospital admissions.

Impaired ion channels regulating Golgi pH may cause altered Golgi morphology. Here authors identify TMEM87A as a pH-regulation cation channel expressed in astrocytes and neurons and determine the cryo-EM structure to understand the ion permeation pathway.

We establish a spin nematic phase in the square-lattice iridate Sr₂IrO₄ and find a complete breakdown of coherent magnon excitations at short-wavelength scales, suggesting a many-body quantum entanglement in the antiferromagnetic state.

Pseudovirus-based SARS-CoV-2 spike deep mutational scanning is used to measure how mutations across the spikes affect ACE2 binding, cell entry or escape from human sera, producing data that could enable better prediction of viral evolution.

Evolution of viruses undermines the efficacy of vaccines and antibody therapies. To overcome this challenge, authors describe a strategy for prefusion-stabilization to provide proof-of-principle for fusion-machinery sarbecovirus vaccines.

A major challenge for spin based electronics is the electrical control of magnetization. Here, Kang et al demonstrate how electric field control of the Rashba effect in a Pt/Co/AlOx can enable control of the spin-orbit torque and allow for field free switching of the magnetization.

It is well known that the interplay between molecular ordering and interface geometry can determine the morphology of two-dimensional systems. Here, the authors report facet formation in water droplets, driven by peptide assembly, and investigate the structural and sequence motifs that affect this behaviour.

Metal-thiolate complexes are the precursors to atomically precise metal nanoclusters. Here, the authors show that the extent of metal-ligand interaction is key to controlling the size and uniformity in the synthesis of metal nanoclusters.

HK022 put is an RNA element that inhibits transcription termination without aids from protein factors. Here, authors solved cryo-EM structures of put-associated RNA polymerase and showed the structure of putRNA and its binding to the RNA polymerase.

PCR is an essential method for the amplification and manipulation of nucleic acids, but the requirement for a thermocycler limits access. Here, authors engineer a helicase to replace the heating step of PCR with enzymatic unwinding, allowing the isothermal amplification of fragments up to 6 kb.

In the ATP-dependent proteases, separate internal chambers function in substrate unfolding and degradation. These chambers are linked by narrow channels, requiring a protein to unfold completely in order to pass between them. New work suggests that substrates are unraveled from one end first and are translocated vectorially into the proteolytic core.

A modular de novo designed biosensor platform consisting of a cage and key molecule is developed, and used to create sensors for seven distinct proteins including the spike protein from SARS-CoV-2 and anti-SARS antibodies.

The oxide passivation layer on the lithium metal surface causes uneven deposition and stripping in lithium metal batteries. Here authors introduce uniform homo-epitaxial lithium deposition on the metal surface to alleviate this issue and improve the cycle stability of the lithium metal batteries.

Ha and colleagues show that loss of PD-1 expression on regulatory T cells in the tumor environment reduces their metabolic fitness and proliferative capacity.

Aqueous zinc ion batteries are good systems for large-scale energy storage. Here, the authors report that the corrosion of zinc metal anode is the origin of limited lifetime of vanadium oxide-based aqueous zinc ion batteries, and supressing corrosion improves the calendar and cycle lifetime markedly.

Focusing beyond the diffraction limit is achieved by using elastic light scattering from a highly turbid medium to convert propagating far-field components into near-field wave vectors. This finding may open new avenues for the subwavelength control of light, with applications in nanolithography and the interconnection between nanoelectronics and nanophotonics.

The GEMM riboswitch is conserved in diverse bacteria and recognizes the second messenger c-di-GMP which mediates many processes, such as the transition between sedentary and motile behavior. The structure of the GEMM riboswitch with ligand now elucidates ligand recognition and specificity.

Atmospheric CO₂ is governed by CO₂ gains (e.g., via Southern Ocean outgassing) and losses (e.g., via North Atlantic absorption). Using a novel method to estimate air–sea CO₂ exchange signals, the authors show that North Atlantic CO₂ absorption became more efficient and contributed to lowering atmospheric CO₂ during ice ages.

In a study of children with high genetic risk aged 2 years or older, a risk score integrating pancreatic islet autoantibodies, genetic factors and family history is highly predictive of type 1 diabetes in the subsequent 8 years.