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The mantle has contributed more largely to tungsten mineralization processes and tungsten pre-enrichment in the crust than previously thought, based on multi-isotope data analysis of major tungsten provinces worldwide coupled with machine learning.

Akkermansia muciniphila can promote intestinal pathogen infection in mice via microbial metabolite succinate production, but the expansion of A. muciniphila is strictly controlled by ILC3s through the regulation of intestinal galactosylation.

Here, the authors report tunable luminescence from a single lanthanide ion upon changing excitation conditions through co-doping an energy-modulator ion, thus adjusting the photon transition process of the lanthanide activator ion. Optical encryption has also been demonstrated as an application of this universal strategy.

Prostate cancer is heterogenous in response to therapy. Here, the authors analyse genomics, transcriptomics, proteomics and phosphoproteomics data from 145 prostate cancer patients to identify NANS as a therapeutic target in prostate cancer.

Inhibitor of differentiation 1 (ID1) has been described as a cancer-promoting factor and also involved in the formation of an immunosuppressive tumor microenvironment. Here the authors report that ID1-expressing tumor associated macrophages favor colorectal cancer progression by promoting cancer cell stemness and CD8⁺ T cell exclusion.

Socioeconomic status is multidimensional and can change over time. Xu, Lui, Ji et al. found dimension-specific, late-stage-specific and change-specific socioeconomic effects on brain, cognition, personality and emotion.

Adenoids and tonsils in children can become hypertrophic because of multiple infections. Here the authors use single cell transcriptomics to assess the immune cell composition of these hypertrophic organs and find B, T and NK cells and exhausted memory CD4 T cells indicating immune changes in these organs associated with respiratory infection.

Cs₃LnCl₆ (Ln = Ce–Lu) microcrystals were prepared via recrystallization method at room temperature. Cs₃TbCl₆ microcrystals exhibit high light yield and excellent imaging ability under X-ray irradiation.

Oligomers are among the various chemical contaminants that can derive from the breakdown of microplastics and that are challenging to detect. A purposely designed platform allows detection of a large number of oligomers, providing an important step towards their risk assessment.

Omrani, Krepelova et al. report that aging-induced proinflammatory IFNγ/Stat1 signalling primes intestinal stem cells to a secretory fate and to antigen presenting cells impairing the regenerative capacity of the aging gut epithelium.

In this randomized controlled trial, the authors investigate the benefits of over-the-counter hearing aids on depression symptoms in older adults with mild–moderate hearing loss.

Using single-cell and spatial molecular profiling of infarcted mouse and human hearts, Li, Ni, Wang and colleagues identify a subset of cardiac fibroblasts expressing CD248 that plays a critical role in fibroblast–T cell interaction, and show that disrupting this interaction with monoclonal antibodies or anti-CD248 chimeric antigen receptor T cells results in reduced cardiac fibrosis and improved function.

Methotrexate-loaded tumour-cell-derived microvesicles induce neutrophil-mediated antitumour activity and can relieve biliary obstructions in patients with extrahepatic cholangiocarcinoma.

In a phase 1 trial, pediatric or adult patients with T-ALL who received CD5-targeted CAR-T cell therapy using cells from previous or newly matched donors showed an encouraging clinical response rate, with some severe adverse events that required attention and effective management.

Single-atom Fe–N–C catalysts are the most promising alternative to Pt-group metal catalysts for the cathodic oxygen reduction reaction in fuel cells, but while the chemical environment of their active centres is well understood, their electronic structure remains elusive. Now, using molecular model catalysts, a high-spin trivalent FeN₄ site with an axial hydroxyl ligand is identified as the active site in Fe–N–C catalysts.

Cross-ancestry and sex-stratified genome-wide association analyses for 21 amygdala volumetric traits in East Asian and European individuals provide insight into the genetic architectures of amygdala and subnucleus volumes.

Cohort-scale integration of clinical and proteomic data from tumor tissues in patients with pancreatic ductal adenocarcinoma led to the identification of a prognostic risk model for patient stratification as well as biomarkers of response to adjuvant chemotherapy, validated in independent external cohorts.

The exact role FoxO3 in the regulation of cardiac regeneration remains unclear. Here, the authors show that FoxO3 negatively controls cardiomyocyte proliferation and heart regeneration in postnatal mice at least in part by promoting Sfrp2 expression.

Accurate organ at risk (OAR) segmentation is critical to reduce the radiotherapy post-treatment complications. Here, the authors develop an automated OAR segmentation system to delineate a comprehensive set of 42 H&N OARs.

Multiple myeloma bone disease is characterized by the development of osteolytic bone lesions. Here, the authors demonstrate that the checkpoint inhibitor PD-1H functions as a potential MMP-13 receptor on osteoclasts, mediating MMP-13 induced cytoskeleton reorganization, fusogenesis and bone resorption and further regulating osteolytic lesions.

Jia et al. uncover a molecular mechanism based on the balance of nitrate-sensitive protein–protein interaction between ferredoxins ZmFd4 and ZmFd9, together antagonistically targeting ZmNiR enzymes, thus regulating NO₃^– assimilation in maize.

Regulating oxidative phosphorylation and restoring redox homeostasis are crucial in neurological disorders. Here, the authors develop a top-down membrane self-assembly strategy to develop stem cell-derived artificial organelles (SAOs) that mimic mitochondrial oxidative phosphorylation without the risks associated with stem cell therapy.

Two-dimensional topological insulators support edge conduction electrons but its realization in real materials is rare. Here, Peng et al. report the direct observation of topological states at the step edge of WTe₂.

Endothelialization of the left atrial appendage (LAA) occluder is vital in addressing device-related thrombosis. Here, the authors report LAA occluders integrated with drop-shaped microgrooves to guide unidirectional cell migration for enhanced endothelialization.

Efficient CO₂ electroreduction to C₂₊ products at high current densities remains a significant challenge. Here, the authors develop inherently hydrophobic and hierarchically porous Cu supraparticles with enhanced mass transfer and abundant C-C coupling sites for ampere-level CO₂-to-C₂₊ synthesis.

Air pollution can affect people’s emotional status and well-being. Here, the authors simulate fixed-scene images to show that under the atmospheric conditions in Beijing, negative emotions occur when air quality index of PM_2.5 increases to approximately 150.

Aerodynamic analysis of SARS-CoV-2 RNA in two hospitals in Wuhan indicates that SARS-CoV-2 may have the potential to be transmitted through aerosols, although the infectivity of the virus RNA was not established in this study.

The spread of many infectious diseases substantially relies on aerosol transmission to the respiratory tract. Here, the authors design an intranasal mask with the ability to intercept viral aerosols, entrap and inactivate virus, thus preventing respiratory tract infection.

OLEDs that emit circularly polarized light are essential for many technologies. Here, the authors develop OLEDs based on chiral nanoparticles that have large emission dissymmetry factors and high external quantum efficiencies.

The coupling of acetonitrile into succinonitrile via a dehydrogenative route is highly attractive in terms of valuable chemical synthesis and green hydrogen energy production. Here, the authors report succinonitrile synthesis with high selectivity and rate via a light driven dehydrogenative coupling reaction of CH₃CN over the anatase TiO₂ supported Pt catalyst.

Organic fluorescent nanoparticles have potential biomaterials applications due to their low-toxicity and ‘green’ synthesis. Here, a series of self-assembled nanoparticles and polymers are synthesized with intense visible fluorescence stemming from chromophores of hydrogen-bonded monoacylglycerol clusters.

It is challenging to regulate the interfacial motifs of Cu⁰-Cu⁺ sites to understand roles of Cu⁰ and Cu⁺ for nitrate electrochemical reduction reaction. Here, the authors report a tunable construction of Cu⁰-Cu⁺ interfacial structure by modulating the size-effect of Cu₂O electrocatalysts.

Lu and colleagues show that signaling through the lactate receptor HCAR1 in colorectal tumor cells promotes the recruitment of immunosuppressive CCR2⁺ PMN-MDSCs and that inhibition of HCAR1 by reserpine augments the CD8⁺ T cell-mediated antitumor immune response.