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A reinforcement learning-based virtual reality system, implementing a series of sport sessions with coaching, was as effective as standard physical activity in reducing fat mass in adolescents, with positive effects on cognition.

Frost is typically seen as a threat to plants and is expected to lead to decreased ecosystem carbon uptake due to reduced photosynthesis. However, this research shows that spring frosts can actually enhance ecosystem carbon absorption, while autumn frosts behave as expected, prompting an increase in carbon emissions.

Thin films of a single-crystal dielectric—antimony oxide—can be epitaxially grown at wafer scales on graphene-covered copper surfaces and then used to transfer dielectric/graphene stacks, or be integrated as a two-dimensional dielectric onto other materials.

Yu and colleagues present a single-cell transcriptomic landscape of olfactory neuroblastoma, characterizing different tumor subtypes and cancer cell responses to drug treatments.

Genome-wide association and fine-mapping analyses in ancestrally diverse populations implicate candidate causal genes and mechanisms underlying type 2 diabetes. Trans-ancestry genetic risk scores enhance transferability across populations.

The realization of active metasurfaces operating in the infrared range remains challenging due to design complexities and scarcity of suitable materials. Here, the authors report the realization of electrically programmable plasmonic metasurfaces integrated with graphene transistors, enabling pixelated thermal emission with low cross-talk and enhanced coherence.

A meta-analysis of genome-wide association studies of type 2 diabetes (T2D) identifies more than 600 T2D-associated loci; integrating physiological trait and single-cell chromatin accessibility data at these loci sheds light on heterogeneity within the T2D phenotype.

Solar-powered, untethered, sustained flight of an ultralight micro aerial vehicle under natural sunlight conditions is achieved using an electrostatic-driven propulsion system with a high lift-to-power efficiency.

A trans-ancestry meta-analysis of GWAS of glycemic traits in up to 281,416 individuals identifies 99 novel loci, of which one quarter was found due to the multi-ancestry approach, which also improves fine-mapping of credible variant sets.

Atomically thin materials can form ionic sieves, in which certain species pass through the films, and others are prevented. Here, the authors synthesize nanoporous membranes using chemical vapor deposition and electrochemistry and reveal the mechanism behind the large ion selectivity they observe.

Genes encoding the class A auxin-response factor group of plant transcriptional activators reside in constitutively open chromatin, enabling their continual regulation by transcriptional repressors to modulate auxin signalling throughout development.

Effective delivery of drugs to bone marrow has potential for leukemia treatment. Here the authors report the delivery of chemotherapy drug Ara-C with HSPC cell membrane derived-biomimetic vesicles, which target leukemia stem cells thereby effectively inhibit its progression.

Here the authors pull apart the cellular composition of the tumor microenvironment using RNA sequencing data from a wide variety of cancer types. They identify immunity quantitative trait loci and integrate these data with analysis of colorectal cancer cohorts, creating a polygenic risk score and a database for community access.

Lithium–sulfur batteries are promising energy storage devices where catalysis can play an important role, but developing design principles for optimal performance remains a challenge. Now, a series of p-block metal sulfide cathodes are evaluated, revealing a direct correlation between the p electron gain of sulfur in the sulfide material and the apparent activation energy for the sulfur reduction reaction.

Adipocytes store lipid in spherical droplets whose size is determined by lipid exchange and transfer proteins. Sun et al.show that Perilipin1 promotes the growth of lipid droplets by activating the lipid transfer protein Fsp27.

The haptic interface is an essential part of human–machine interfaces where tactile information is delivered between human and machine. Yao et al. develop a soft, ultrathin, miniaturized and wireless electrotactile system that allows virtual tactile information to be reproduced over the hand.

Here the authors study diet-induced weight gain/loss to identify chromatin architectures in adipose tissue (AT) associated obesity in a pig model. They found parallels and species-specific regulatory elements in humans and pigs that underpin AT specialization.

In order to understand the role of formaldehyde in living systems, real-time monitoring is required. Here the authors report a genetically encoded, reaction-based formaldehyde sensor (FAsor) that enables visualisation of formaldehyde in mammalian cells and tissues.

A synthesis of global change experiments that manipulated temperature, precipitation, carbon dioxide or nitrogen identifies a need to consider site-specific factors and interactions in Earth system models.

Spin manipulation for quantum information processing often requires cost-intensive sample design and cryogenic temperatures. Now, surface functionalization of CsPbBr₃ quantum dots enables coherent optical manipulation of hole spins under ambient conditions.

Observation of a Bloch-Siegert shift has remained elusive. Here, Wu et al, reports spin-selective Bloch-Siegert shift in lead halide perovskite quantum dots, and highlights the importance of many-body interactions in correctly modeling the shift.

LRP6 is known for its role as a Wnt co-receptor essential for the canonical Wnt/β-catenin signaling. Here, Li et al. show that LRP6 exerts a Wnt-independent scaffold function and regulates connexin 43 gap junction formation and coupling of cardiomyocytes in mouse hearts.

This Review introduces coherent light–matter interactions in solution-processed lead halide perovskite colloidal nanocrystals, discussing opportunities and challenges in the context of quantum information technologies.

A linkage-specific tool for K29-linked polyubiquitin was developed, enabling the discovery that K29-linked ubiquitination participates in multiple cellular pathways, including the proteotoxic stress response and cell cycle regulation.

Screening a library of compounds identifies several inhibitors of TNF-induced necroptosis, including Ibrutinib as an inhibitor of RIPK3 and Quizartinib as an indirect RIPK1 kinase activity inhibitor.