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In situ methods for water quality monitoring is crucial for global water use and management, though many conventional sensors have slow response time and are non-recyclable. Here, the authors report a recyclable amphiphobic dielectric material for fast monitoring of water pollutants.

The miniaturization of spectrometers to a submillimeter-scale footprint opens opportunities for applications in hyperspectral imaging and lab-on-a-chip systems. Here, the authors report a high-performance single-pixel photodetector spectrometer based on the III-V semiconductor p-graded-n junction, featuring a voltage-tunable optical response.

The genetic basis underlying resistance to Sclerotinia stem rot (SSR) in oilseed rape remains elusive. Here, the authors identify BnaA07.MKK9 as a pivotal regulator of SSR resistance in oilseed rape by GWAS, providing new insights into plant defense mechanisms against necrotrophic pathogens.

NICER is a broad-spectrum nanovaccine based on a nanovesicle system that can induce an effective immune response via epigenetic regulation to target both cancer stem-like cells and bulk tumour cells to prevent tumour recurrence.

Preparing room temperature phosphorescent materials from biomass is important but challenging. Here, the authors report the use of liquid monomer 2-hydroxyethyl acrylate for dissolution of lignin and subsequent solvent-free preparation of lignin-based RTP materials.

Perovskite solar cells often rely on ordered molecular contacts for favourable charge-carrier transport, and any organizational disruption reduces device efficiency. Now a contact featuring an orthogonal π-skeleton has been shown to afford a high resilience to external stimuli plus long-term durability in accelerated-ageing tests.

Convenient and sustainable photoactivated room temperature phosphorescent (RTP) materials exhibit great potential in a wide ranging of applications but are difficult to obtain. Here the authors develop a photoactivated RTP materials by covalently attaching lignin to polylactic acid.

Most LiDARs have an intrinsic tradeoff between acquisition rate and non-ambiguity range. Researchers demonstrated a LiDAR called RRMFC based on an integrated lithium niobate frequency comb, leading to a 1.79 GHz acquisition rate and infinite non-ambiguity range.

Yu and colleagues present a single-cell transcriptomic landscape of olfactory neuroblastoma, characterizing different tumor subtypes and cancer cell responses to drug treatments.

Fu et al. describe a pathogen effector, HaRxL10 that suppresses plant immunity and interferes with plant development by hijacking the clock component CHE to perturb its function in transcriptional regulation.

Single crystals of a helical covalent polymer have been obtained from an achiral monomer through spiroborate formation. Polymerization and crystallization occur simultaneously to give a network of pairs of entwined helical strands of the same handedness. No strong non-covalent interactions were observed between the two helical polymers forming a pair; instead, each interacts with neighbouring pairs through hydrogen bonding.

Wang et al. reveal that epigenetic changes driven by zinc finger MYND-type containing 8 promote the transition from adenocarcinoma to antiandrogen-resistant neuroendocrine prostate cancer and offer a therapeutic approach by targeting the histone reader with a small molecule.

Healthy and sustainable diets that better match the dietary preferences and economic affordability of specific groups are needed to achieve the Sustainable Development Goals. To address this gap, this study proposes a region-specific reference diet for China and compares it to global dietary guidelines.

Reactivating adult cardiomyocyte proliferation is key to heart regeneration post-injury. Here, authors show that medium from human iPSC-derived primitive macrophages (hiPM-cm) induces adult cardiomyocyte proliferation and promotes heart regeneration.

The FarmGTEx Project aims to understand genetic control of gene activity under diverse biological and environmental contexts in domestic animals, providing a foundation for improving animal precision breeding, adaptation and human health.

Exercise can increase the expression of microglial ceramide synthase 1 (CerS1), regulates sphingolipid metabolism, and improves depressive-like behaviors in adolescent mice.

A nitrate-induced transcription factor TaTCP6 is identified as a central regulator for the efficient and balanced utilization of nitrate and phosphorus, and a moderate increase in its expression promotes wheat yield.

Zhou et al. developed a specific small-molecule inhibitor of astrocytic Kir4.1 channels, Lys05, which exerts rapid-onset antidepressant effects in rodents without unwanted side effects, indicating Kir4.1 as a promising drug target.

The mitochondrial unfolded protein response is shown to inhibit pluripotency during somatic cell reprogramming and to inhibit the mesenchymal-to-epithelial transition through c-Jun-mediated histone acetylation.

The haptic interface is an essential part of human–machine interfaces where tactile information is delivered between human and machine. Yao et al. develop a soft, ultrathin, miniaturized and wireless electrotactile system that allows virtual tactile information to be reproduced over the hand.

Electrical stimulation holds promise for enhancing neuronal differentiation of neural stem cells to treat traumatic brain injury. Here, the authors wrap stem cells with wireless electrical nanopatches and apply electrical stimulation in-situ to individual nanopatch-wrapped stem cells on demand

TEMPOmap combines pulse-chase metabolic labeling with multiplexed three-dimensional in situ sequencing to simultaneously profile the age and subcellular ___location of individual RNA molecules from thousands of genes to reveal RNA kinetic landscapes.

Researchers demonstrate the ambient-condition observation of Floquet states in CdSe nanoplatelets, a colloidal analogue of quantum wells.

Mosses support carbon sequestration, nutrient cycling, organic matter decomposition and plant pathogen control in soils across the globe, according to a global survey of soil attributes in ecosystems with and without mosses.

D-LMBmap is a fully automated pipeline for mesoscale connectomics including deep-learning modules for axon segmentation, brain region segmentation and whole-brain registration. D-LMBmap works accurately across cell types and modalities.

Catalysts used for steam methane reforming frequently suffer from deactivation by coking and oxidation. Here an active Cu–Rh plasmonic antenna–reactor photocatalyst is selective and stable under illumination but deactivates under purely thermal conditions. The thermally deactivated catalyst can then be regenerated under illumination.

Cell fate canalization is a core biological event. The authors uncover the role of ARID1A at a super-enhancer region of osteoclast lineage master transcription factor, and antagonistic action between distinct BAF complexes in the proper cell fate canalization.

In global drylands, soils tend to be more fertile beneath tree, shrub and grass islands. Soil fertility was greater beneath taller and wider plants but was unaffected by either grazing pressure or the type of herbivore.

smFRET studies of the M. tuberculosis IleS translational T-box riboswitch support a two-step tRNA binding mechanism and the use of conformational selection for tRNA 3’ end recognition, which is distinct from the one used by transcriptional T-boxes.

The bulk photovoltaic effect holds promise for various optoelectronic applications, but it is usually restricted to non-centrosymmetric materials operating in the visible range. Here, the authors report a surface photogalvanic effect spanning from visible to midinfrared wavelengths in a centrosymmetric topological insulator, Ag₂Te.

Understanding the spatiotemporal dynamics underlying pathology can shed light on its mechanisms. Here the authors introduce STARmap PLUS, a method that combines high-resolution spatial transcriptomics with protein detection.

The molecular mechanism underlying the resistance of AKT inhibitors in breast cancer is still elusive. Here, the authors demonstrate that BRD4/FOXO3a axis upregulates CDK6 promoter activity to promote resistance to AKT inhibition in breast cancer cells and that blocking the action of CDK6 re-sensitizes resistant cancer cells to growth inhibition.

While chemical-induced transcriptional profiles reveal drug mechanisms, inherent noise limits their utility. Here, authors present TranSiGen, a deep representation learning model that denoises and reconstructs these profiles, demonstrating its efficacy in downstream drug discovery tasks.

By combining p-type transistors made with silicon-on-insulator technology and n-type transistors made with two-dimensional molybdenum disulfide, heterogeneous complementary field-effect transistors can be fabricated on the wafer scale.

In situ spatial transcriptomic analysis of more than 1 million cells are used to create a 200-nm-resolution spatial molecular atlas of the adult mouse central nervous system and identify previously unknown tissue architectures.

A microneedle patch that samples and quantifies target protein biomarkers in interstitial fluid allows for longitudinal monitoring of the levels of a range of disease-relevant biomarkers, as shown in live mice.

Fluorescence imaging and fluorescence recovery after photobleaching assays reveal that the mitochondrial nucleoid forms a suborganelle via liquid–liquid phase separation interactions between mitochondrial DNA and the mitochondrial transcriptional machinery.

Here the authors show disturbing parental histone inheritance in cancer cells drives tumor progression by reprogramming the epigenetic profile and conferring fitness advantages to some of the newly emerged subclones.

An introgression platform for transferring genetic variations of Aegilops tauschii to hexaploid wheat is established based on synthetic octoploid wheat. Combined with newly generated genome resources of A. tauschii, it represents a powerful tool for wheat gene discovery and breeding.

mRNA with engineered poly(A) tails produces prolonged higher levels of protein.

Single-atom catalyst (SAC) has emerged as a frontier in heterogeneous catalysis yet its robustness remains a critical concern. Here, a highly active, selective and robust Ru₁-N₃ SAC is explored for a challenging reaction, reductive amination of aldehydes/ketones for synthesis of primary amines.