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Cellular exhaustion can limit the ability of immune cells to control tumors. Here the authors show that expression of the transcription factor Irf4 marks NK cell percursors that will go on to become exhausted mature NK cells and identify targets to interfere with this trajectory to enhance control over melanoma metastasis.

The Wnt signalling pathway is essential for development and the maintenance of stem cells. Here, the authors reveal how LGR4 and RSPO2 modulate ZNRF3 conformations and assembly heterogeneity, stabilising ZNRF3 in its inactive state to enhance Wnt signalling. These findings offer insights for the development of targeted therapies for Wnt-driven cancers.

The authors demonstrate standing ceramic circuit boards (S-CCBs) with high-resolution and high aspect-ratio fabricated via sacrificial coating-assisted micro-3D printing, which have both high-density integration and large current-carrying capacity

Nanopore direct RNA sequencing is promising for epitranscriptome study but remains limited in single-molecule resolution. Here, the authors develop SingleMod, a tool for accurate single-molecule m6A detection from DRS and reveal cross-species epitranscriptome landscapes at single-molecule level.

IL-6 is an important cytokine in the tumour microenvironment, but its role in regulating autophagy in cancer cells is unclear. Here the authors show that IL-6 activates autophagy in colorectal cancer through the interaction between JAK2 and autophagy regulator, BECN1, which leads to chemotherapeutic resistance.

The human stomach is divided into seven anatomically distinct regions but their protein composition is largely unknown. Here, the authors present a region-resolved map of the healthy human stomach mucosa as well as mucosa proteomes of tumor and tumor nearby tissue from gastric cancer patients.

The molecular mechanisms underlying metabolic remodelling in colorectal cancer (CRC) are not completely elucidated. Here, they authors show that the oncogenic protein MYG1 promotes CRC progression not only through regulating mitochondrial activity, but also through activating a nuclear-associated pathway for glycolysis increase.

Interlayer coupling strength classifies 2D materials into layered and non-layered types. Here authors introduce the concept of quasi-layered domino-structured materials, the interlayer of which have a synergistic blend of vdW forces and covalent bonds.

The Colorado potato beetle, a major pest of potato crops, displays conspicuous coloration to advertise their toxicity to predators, but the identity of the toxic compounds is unclear. Here, Kang et al. show that the insect releases toxic hydrogen cyanide, which results from the degradation of cyano-compounds produced by commensal bacteria.

Vacuolar sugar transporters have a key role in plant sugar homeostasis. This Review discusses recent advances concerning the interconnected roles of vacuolar sugar transporters from different protein families in plant development and stress responses.

Aerodynamic analysis of SARS-CoV-2 RNA in two hospitals in Wuhan indicates that SARS-CoV-2 may have the potential to be transmitted through aerosols, although the infectivity of the virus RNA was not established in this study.

Nodal line semimetals have been observed in three-dimensional materials but are missing in two-dimensional counterparts. Here, Feng et al. report two-dimensional Dirac nodal line fermions protected by mirror reflection symmetry in monolayer Cu₂Si.

Organocopper species are widely used in synthetic chemistry. Here the authors study the structure of the anionic complex formed from copper salts and lithium halides, showing it to be a key intermediate in the formation of organocuprates, and also show that Cu(II) precursors can form Gilman reagents.

Until now, efforts to enhance the performance of nanolasers have focused on reducing the rate of non-radiative recombination. Here, Burgess et al.employ controlled impurity doping to increase the rate of radiative recombination.

Brain iron accumulation has been associated with multiple brain disorders, but the mechanism is not well understood. Here, the authors investigate the genetic determinants of brain iron accumulation and their implications for neuropsychiatric disorders.

Here, the authors synthesize a variety of ultra-thin III–V single crystals, ranging from ultra-narrow to wide bandgap semiconductors, through enhancing the interfacial interaction between the III–V crystals and the growth substrates.

Intermolecular interactions have a crucial role in the adsorption of molecules on a surface, however their role in promoting phase transitions is less well known. Here, the authors report an abnormal phase transition between a high-density liquid crystal and low-density solid in the case of carbon monoxide on Cu(111), driven by intermolecular interactions and entropy.

A foundation model learns transcriptional regulatory syntax from chromatin accessibility and sequence data across a range of cell types to predict gene expression and transcription factor interactions, with generalizability to unseen cell types.

Limited whole genome sequencing (WGS) of Asian populations results in a lack of representative reference panels, hindering imputation of Asian ancestry-specific genetic variants. Here the authors use WGS data from 11,067 individuals across 17 Asian countries to create a new reference panel which shows improved imputation accuracy for South Asian populations.

Modules of foldable crystalline silicon solar cells retain their power-conversion efficiency after being subjected to bending stress or exposure to air-flow simulations of a violent storm.

A device that integrates the enrichment and electrochemical detection, in less than one hour, of tumour extracellular vesicles bearing clinically relevant tumour biomarkers accurately classifies patients with colorectal cancer.

Effectively delivering medications to the renal tubule to delay or halt chronic kidney disease progression remains a significant unmet clinical challenge. Here, authors introduce an innovative strategy for renal tubule targeting using biomimetic high-density lipoprotein (bHDL) nanoparticles.

RNF214 ubiquitin ligase is understudied. Here the authors show RNF214 promotes hepatocellular carcinoma progression by inducing non-proteolytic ubiquitylation of TEADs and activating YAP signaling pathway.

Traditional N-alkylation methods, especially for α-tertiary amines, suffer from limitations due to high energy barriers from steric hindrance. In this work, the authors leverage visible light irradiation to enable organoboronic acid addition to sterically hindered ketimines using a three-component coupling of aliphatic amines, ortho-phenolic ketones, and organoboronic acids.

Wang, Zhang, Zheng et al. demonstrate that tumour cell-derived lymphotoxin-β activates NF-κB2 signalling and CCL2/5 secretion in osteoblasts to promote bone metastasis in breast cancer, which may potentially be targeted with a decoy receptor in vivo.

Genome-wide association studies (GWAS) have improved our understanding of the genetic basis of lung adenocarcinoma but known susceptibility variants explain only a small fraction of the familial risk. Here, the authors perform a two-stage GWAS and report 12 novel genetic loci associated with lung adenocarcinoma in East Asians.

RORγt+ group 3 innate lymphoid cells are intimately involved in intestinal homeostasis, their dysregulation is linked to inflammatory gut diseases. Here the authors show that dysregulated Wnt/β-catenin signalling contributes to disturbed regulation of group 3 innate cells and intestinal inflammation.

ATE1 is an essential gene in mammals and is recognized as a master regulator of cells. Here, the authors describe structural insights into human ATE1, revealing mechanisms that regulate arginylation activity in cells.

The challenging synthesis of thermodynamic-unfavored cis-olefins through catalytic cross-coupling reactions requires the synergistic interaction of substrate activating units and configuration-regulating catalysts. Herein, the authors report a photoredox access to Z-alkenes from alkynes and light alkanes with a bifunctional iron-catalyzed system.

The genome sequences of 175 Ebola virus from five districts in Sierra Leone, collected during September–November 2014, show that the rate of virus evolution seems to be similar to that observed during previous outbreaks and that the genetic diversity of the virus has increased substantially, with the emergence of several novel lineages.

The construction of analogues of natural gap junctions would provide a bottom–up strategy for building intercellular communication pathways for synthetic cells. Now artificial intercellular gap junctions have been prepared from unimolecular tubular channels by mimicking the hydrophobic–hydrophilic–hydrophobic triblock structure of natural junction channels.

Phylogenomic analysis of 7,923 angiosperm species using a standardized set of 353 nuclear genes produced an angiosperm tree of life dated with 200 fossil calibrations, providing key insights into evolutionary relationships and diversification.

Acorales is sister to all other monocots and contains only one family with just one genus, Acorus. Here, the authors assemble the genome of the diploid Ac. gramineus and the tetraploid Ac. calamus, reconstruct an ancestral monocot karyotype and gene toolkit, and discuss the origin and evolution of the two species and other monocots.