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Breast cancer cells interact with cancer-associated adipocytes in the microenvironment. Here, the authors report that the cross-talk between these two cell types is dependent on Zeb1, which remodels the tumor-associated adipose microenvironment to confer breast cancer progression.

Zinc is an essential micronutrient for plants, however its excess causes cellular damage. Here, the authors report that natural variation of Trichome Birefringence (TBR) gene confers zinc toxicity tolerance through modulating root cell wall pectin methylesterification in Arabidopsis.

Arginine addiction induced by argininosuccinate synthase (ASSN1) deficiency has been exploited to treat ASS1-deficient cancers. Here, the authors show an alternative therapeutic approach where ASS1 activity is increased by the pesticide spinosyn A and is shown to inhibit breast cancer cell proliferation.

The authors describe a mechanism for the clearance of macromolecules from cerebrospinal fluid in which macromolecules traverse from periarterial to perivenous spaces, at sites where intersecting leptomeningeal perivascular (arteriovenous) spaces overlap.

Targeted degradation has the potential to treat diseases associated with pathological protein build up. Here, the authors report on an oligo-PROTAC which degrades FUS, a protein associated with frontotemporal dementia, demonstrating delivery on DNA nanoflowers for increase blood-brain barrier crossing and retention.

Chang’E-5 and Chang’E-6 lunar soils show higher δ30Si than lunar basalts, with CE-6 having the highest value, suggesting space weathering produced by micrometeorite impacts alters Si isotopes of lunar soils, with stronger effects on the farside.

Insulator-to-metal transitions induced by spontaneous magnetization above room temperature have rarely been observed. Here, the authors show that this transition, along with concurrent high-temperature ferrimagnetic order, is realized in the novel 3d/5d hybridized quadruple perovskite oxide CaCu₃Ni₂Os₂O₁₂.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

A unified framework is presented that integrates observed spatial patterns of individual trees in forests with ecological processes into a novel coexistence theory.

Adipose tissue macrophage (ATM) has been implicated in inflammation and obesity, but the underlying mechanisms are still unclear. Here the authors show that AMPK is suppressed in ATMs from mice fed with high fat diet, leading to subsequent activation of SUCLA2, over-production of succinate and IL-1β, and ultimately inflammation and obesity.

Human vesicular polyamine transporter underpins learning and memory formation by loading polyamines into secretory vesicles. Here, the authors decipher the transporter structure and suggest an antiport mechanism involving both direct and indirect competition between protons and polyamine.

Precise control of fiber morphology remains challenging. This study develops bioinspired gas-liquid spinning to create programmable microstructured fibers and reveals a bubble-mediated dynamic interface adaptive mechanism.

Oxygen is vital for all multicellular organisms and oxygen deprivation, hypoxia, influences cellular functions. Here, the authors develop an oxygen-controlling hydrogel that can be used as a three-dimensional hypoxic microenvironment, and may aid the study of hypoxia-related biological conditions.

While Bell inequalities have been violated several times—mostly in photonic systems—their violations within particle physics experiments are less explored. Here, the BESIII Collaboration showcases Bell-violating nonlocal correlations between entangled hyperon pairs.

Single atom catalysts offer a promising approach for CO₂ electroreduction to CO, but achieving high efficiency remains challenging. Here, the authors report lanthanide single atom catalysts with the transition ability from bridge to linear adsorption that exhibit efficient CO production.

Apiosides are plant bioactive natural products containing apiose, but the details of the key apiosylation reaction in their biosynthesis are missing. Here, the authors identify the apiosyltransferase GuApiGT that could efficiently catalyze 2″-O-apiosylation of flavonoid glycosides, solve its crystal structure and obtain mutants with altered sugar selectivity.

Oxide nanolites crystallisation in natural magma increases melt, and hence bulk magma viscosity mainly due to iron extraction. This increase can be sufficient to drive magma fragmentation depending on magma degassing and ascent dynamics.

Systematic analysis from the Global Burden of Disease study reported that, despite global improvements from 1990 to 2021, dietary iron deficiency-associated disease burden remains high in women, children and residents in low socio-demographic index countries.

Kim and colleagues perform a phase 2 clinical trial (ELM-2) of odronextamab monotherapy in patients with relapsed/refractory diffuse large B cell lymphoma and report on the primary analyses of the efficacy and safety profile.

Upcycling of mixed plastics containing polyvinyl chloride is challenging. This study reports a strategy to co-upcycle polyvinyl chloride with polypropylene to obtain dechlorinated liquid hydrocarbons at high yields at room temperature without the use of external hydrogen or noble metal catalysts.

The oncoprotein ANLN regulates contractile ring assembly during mitosis, has been reported as an oncoprotein. Here, the authors report a role of nuclear ANLN in gene transcriptional regulation through interaction with RNA Pol II and promoting its clustering and phase separation.

Overcoming the suppressive tumor microenvironment (TME) is crucial to improving the efficacy of cancer therapy. Here the authors show that, in mouse cancer models, administration of exogenous IL-16 establishes a Th1-dominant TME via regulation of glutamine catabolism and triggers a Th1 cell-macrophage crosstalk, enhancing anti-tumor immune responses and the efficacy of immunotherapy.

There are more than 2,100 known plant virus species. This work presents full-length three-dimensional structures of a plant virus’s replication machinery, providing insights into its activation and inhibition.

Physical activity is ameliorative for individuals with type 2 diabetes, but most previous studies have relied on self-reported data, which are subject to recall bias. Here, the authors show L-shaped associations of accelerometer-derived physical activity with all-cause mortality, and a negative linear association with cardiovascular disease mortality in diabetic patients.

Development of a ligand-based proximity labeling strategy enables interrogation of the native cell membrane interactome for the GLP-1 receptor in two cell types, revealing new regulators of receptor-mediated signaling and β cell responses.

This study highlights the role Polar regions as a limiting factor in global sustainability due to teleconnection effects, and then propose a SDG target, key indicators, and emphasize Indigenous inclusion and global action.

Suraxavir marboxil, an antiviral drug designed to inhibit the polymerase acidic protein of influenza, alleviates symptoms in individuals with influenza faster than placebo in a phase 3 trial conducted in China.

The isopentenol utilization (IU) pathway has been reported as an alternative synthetic route for terpenoid synthesis, but isopentenol inhibits energy metabolism in baker’s yeast. Here, the authors solve the problem by replacing the mevalonate pathway with the IU pathway for growth-coupled squalene, β-carotene, and limonene production.

Black phosphorus mainly absorbs light in the visible to infrared range through interband transitions. Here, the authors show that through femtosecond ultraviolet excitation they can active a parity-forbidden dark exciton.

Glioblastoma (GBM) is rich in tumor-associated vasculature and it remains to be understood how GBM is supported by vascular endothelial cells. Here, the authors identify that endothelial-secreted proteoglycan endocan acts as a ligand of PDGFR alpha receptor to promote GBM progression and induce therapy resistance.

Rearrangement reactions serve as crucial steps in syntheses of biologically active products and also provide intellectual and conceptual curiosities within the broad field of organic chemistry. Here, the authors report an electrophilic selenylation/semipinacol rearrangement of allenols, catalysed by a chiral Lewis base.

The fabrication of three-dimensional nanoscale structures is important to nanophotonic applications where light is guided and controlled. The optical beam lithography scheme developed by Gan and colleagues enables the fabrication of three-dimensional structures with feature sizes down to 9 nm.

The authors report a vacancy engineering method to simultaneously optimize carrier concentration and maintain high plasticity, achieving a nearly 10% strain in three-point bending tests and a high ZT of ~0.83 at 343 K in (AgCu)0.998Te0.8Se0.1S0.1.

The authors develop a liquid-phase sintering strategy to effectively enlarge material’s grain sizes, thereby achieving single crystal-like electronic transport properties in polycrystalline Mg₃(Bi, Sb)₂.

Symbiotic nitrogen fixation is a tightly regulated process serving as a sustainable source of nitrogen (N) in agriculture. Here it is shown that external N sources precisely regulate N fixation efficiency by modulating iron transport in nodules of legumes.

The authors show that ELL3 maintains chromosomal ploidy by promoting spindle assembly and driving chromosome movement in oocytes. Deficiency of ELL3 results in oocyte aneuploidy and may lead to early miscarriage.

A biomimetic antigen-presenting system uses hexapod heterostructures to probe T-cell recognition at single-cell resolution.

Central nervous system (CNS)-derived regulatory self-peptides are essential for maintaining a continuous dialogue between the CNS and the immune system while balancing overt autoreactivity.

Growth of large-area monolayer transition metal dichalcogenides is critical for their application but remains challenging. Here Yang et al. report rapid chemical vapor deposition of 6-inch monolayer molybdenum disulfide by sufficiently uniformly supplying the precursors and catalysts.

Socioeconomic status is multidimensional and can change over time. Xu, Lui, Ji et al. found dimension-specific, late-stage-specific and change-specific socioeconomic effects on brain, cognition, personality and emotion.

The role of the tumor microenvironment in immunotherapy response in intrahepatic cholangiocarcinoma remains unclear. Here, single cell RNA and TCR sequencing of samples before and after immunotherapy highlights the role of CD8 T-cell status conversion and exhaustion induced by Macro CD5L+ in treatment response.

An avian influenza H7N9 virus causes severe human disease, including acute and often lethal respiratory failure. Here, the authors report that plasma levels of angiotensin II, a regulatory peptide of the renin–angiotensin system, are associated with disease severity and fatal outcome in infected patients.