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Showing 1–50 of 1546 results
Advanced filters: Author: Mo Yang Clear advanced filters
  • A cost-effective all-in-one halide cathode material with high energy density and exceptional cycling stability can be used to achieve energy-dense, durable cathodes for the next generation of all-solid-state batteries.

    • Jiamin Fu
    • Changhong Wang
    • Xueliang Sun
    Research
    Nature
    Volume: 643, P: 111-118
  • Here the authors report asperigimycins, fungal ribosomally synthesized and post-translationally modified peptides with a heptacyclic scaffold. After chemically modifying them for nanomolar anticancer activity, CRISPR screening identifies SLC46A3 as a key transporter for their uptake in cells.

    • Qiuyue Nie
    • Fanglong Zhao
    • Xue Gao
    Research
    Nature Chemical Biology
    P: 1-10
  • Tools to simultaneously trace multiple neuronal projections and/or profile projection neurons for multi-modal investigations are lacking. Here authors introduce Projection-TAGs, a retrograde AAV platform to enable multiplexed spatial neuroanatomical studies, high-throughput multi-modal (transcriptional, and epigenetic) profiling of projection neurons using various commercial assays.

    • Lite Yang
    • Fang Liu
    • Vijay K. Samineni
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18
  • The polarity separation within the carbon-metal bonds of traditional organometallic reagents that endows them with exceptional reactivities also imposes limitations, such as air and moisture sensitivity, and flammability. Here, the authors demonstrate that stable and easily accessible benzylic (or allylic) boronate with mild alkali-metal alkoxide as the activator can act as organometallic reagents.

    • Xueting Liu
    • Daojing Li
    • Shuhua Li
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11
  • The authors use human SEEG recordings during a virtual escape task to identify roles for cognitive and reactive fear circuits in threat evaluation and escape decisions, respectively. They further uncover Theta-band flow from the amygdala to the vmPFC during rapid attacks.

    • Haoming Zhang
    • Jiayu Cheng
    • Haiyan Wu
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17
  • Fluorogenic RNA aptamers such as Mango are powerful tools for RNA imaging. An ultrabright RNA-activated fluorophore with improved photophysical performance has now been developed using a structure-informed, fragment-based screening approach. This system was studied using high-resolution crystallography and applied to image RNA in cells.

    • Mo Yang
    • Peri R. Prestwood
    • John S. Schneekloth Jr
    Research
    Nature Chemistry
    P: 1-8
  • While Bell inequalities have been violated several times—mostly in photonic systems—their violations within particle physics experiments are less explored. Here, the BESIII Collaboration showcases Bell-violating nonlocal correlations between entangled hyperon pairs.

    • M. Ablikim
    • M. N. Achasov
    • J. Zu
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-9
  • Weyl semimetals are interesting because they are characterized by topological invariants, but specific examples discovered to date tend to have complicated band structures with many Weyl points. Here, the authors show that TaIrTe4 has only four Weyl points, the minimal number required by time-reversal symmetry.

    • Ilya Belopolski
    • Peng Yu
    • M. Zahid Hasan
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-7
  • The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.

    • Tim H. H. Coorens
    • Ji Won Oh
    • Yuqing Wang
    Reviews
    Nature
    Volume: 643, P: 47-59
  • This study uses genetic crossing to identify the genes underlying the differences in virulence between two Cryptosporidium isolates. Candidate genes are validated using genetic editing, revealing that the small granule protein SKSR1 is a key virulence factor in Cryptosporidium.

    • Wei He
    • Lianbei Sun
    • Lihua Xiao
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15
  • Water plays an essential role in enzyme catalysis, but direct observations linking enzyme catalysis and active-site water pose a significant challenge due to experimental difficulties. Here, the authors employ an ultraviolet photolysis technique with temperature-controlled X-ray crystallography to track the catalytic pathway of carbonic anhydrase II at 1.2 Å resolution.

    • Jin Kyun Kim
    • Seon Woo Lim
    • Chae Un Kim
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14
  • A special class of topological Weyl semimetal state is predicted without respecting Lorentz symmetry. Here, Jianget al. report direct visualization of the unique surface Fermi arcs of MoTe2, confirming its type-II topological Weyl semimetal nature.

    • J. Jiang
    • Z.K. Liu
    • Y.L. Chen
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-6
  • The authors make a terahertz device utilizing collective electronic states in 1T-TaS2 that achieves reconfigurable logic operations through dynamic charge-density-wave phase manipulation. The device shows exceptional performance metrics and enables secure multicolor recognition for next-generation encrypted communications.

    • Xin Sun
    • Kening Xiao
    • Weida Hu
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-10
  • The correlated errors in superconducting qubits have been linked to high-energy particle impacts from cosmic rays, but a direct observation has been lacking. Here, the authors measure the quasiparticle bursts and correlated errors and separate the contributions of cosmic-ray muons and γ-rays in a 63-qubit processor.

    • Xuegang Li
    • Junhua Wang
    • Hai-Feng Yu
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-8
  • Engineered pyroptotic vesicles formed during tumour cell pyroptosis and engineered as personalized tumour vaccines can activate a robust antitumour immune response for post-surgical tumour recurrence inhibition.

    • Zhaoting Li
    • Yixin Wang
    • Quanyin Hu
    Research
    Nature Nanotechnology
    P: 1-11
  • GIANT, a genetically informed brain atlas, integrates genetic heritability with neuroanatomy. It shows strong neuroanatomical validity and surpasses traditional atlases in discovery power for brain imaging genomics.

    • Jingxuan Bao
    • Junhao Wen
    • Li Shen
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18
  • Serine metabolism is essential for leukemogenesis and stemness in acute myeloid leukemia (AML). Here the authors show that targeting IGF2BP3 disrupts the serine synthesis pathway in AML cells in an RNA N6-Methyladenosine modification dependent manner, sensitizing AML cells to serine and glycine deprivation.

    • Feng Huang
    • Yushuai Wang
    • Hengyou Weng
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18
  • Analyses of 2,658 whole genomes across 38 types of cancer identify the contribution of non-coding point mutations and structural variants to driving cancer.

    • Esther Rheinbay
    • Morten Muhlig Nielsen
    • Christian von Mering
    ResearchOpen Access
    Nature
    Volume: 578, P: 102-111
  • In somatic cells the mechanisms maintaining the chromosome ends are normally inactivated; however, cancer cells can re-activate these pathways to support continuous growth. Here, the authors characterize the telomeric landscapes across tumour types and identify genomic alterations associated with different telomere maintenance mechanisms.

    • Lina Sieverling
    • Chen Hong
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13
  • The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 cancer whole genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

    • Lauri A. Aaltonen
    • Federico Abascal
    • Christian von Mering
    ResearchOpen Access
    Nature
    Volume: 578, P: 82-93
  • Integrative analyses of transcriptome and whole-genome sequencing data for 1,188 tumours across 27 types of cancer are used to provide a comprehensive catalogue of RNA-level alterations in cancer.

    • Claudia Calabrese
    • Natalie R. Davidson
    • Christian von Mering
    ResearchOpen Access
    Nature
    Volume: 578, P: 129-136
  • Whole-genome sequencing data from more than 2,500 cancers of 38 tumour types reveal 16 signatures that can be used to classify somatic structural variants, highlighting the diversity of genomic rearrangements in cancer.

    • Yilong Li
    • Nicola D. Roberts
    • Christian von Mering
    ResearchOpen Access
    Nature
    Volume: 578, P: 112-121
  • Whole-genome sequencing data for 2,778 cancer samples from 2,658 unique donors across 38 cancer types is used to reconstruct the evolutionary history of cancer, revealing that driver mutations can precede diagnosis by several years to decades.

    • Moritz Gerstung
    • Clemency Jolly
    • Christian von Mering
    ResearchOpen Access
    Nature
    Volume: 578, P: 122-128
  • The authors present SVclone, a computational method for inferring the cancer cell fraction of structural variants from whole-genome sequencing data.

    • Marek Cmero
    • Ke Yuan
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15
  • The characterization of 4,645 whole-genome and 19,184 exome sequences, covering most types of cancer, identifies 81 single-base substitution, doublet-base substitution and small-insertion-and-deletion mutational signatures, providing a systematic overview of the mutational processes that contribute to cancer development.

    • Ludmil B. Alexandrov
    • Jaegil Kim
    • Christian von Mering
    ResearchOpen Access
    Nature
    Volume: 578, P: 94-101
  • In this study the authors consider the structural variants (SVs) present within cancer cases of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. They report hundreds of genes, including known cancer-associated genes for which the nearby presence of a SV breakpoint is associated with altered expression.

    • Yiqun Zhang
    • Fengju Chen
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14
  • Cancers evolve as they progress under differing selective pressures. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, the authors present the method TrackSig the estimates evolutionary trajectories of somatic mutational processes from single bulk tumour data.

    • Yulia Rubanova
    • Ruian Shi
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12
  • There’s an emerging body of evidence to show how biological sex impacts cancer incidence, treatment and underlying biology. Here, using a large pan-cancer dataset, the authors further highlight how sex differences shape the cancer genome.

    • Constance H. Li
    • Stephenie D. Prokopec
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-24
  • With the generation of large pan-cancer whole-exome and whole-genome sequencing projects, a question remains about how comparable these datasets are. Here, using The Cancer Genome Atlas samples analysed as part of the Pan-Cancer Analysis of Whole Genomes project, the authors explore the concordance of mutations called by whole exome sequencing and whole genome sequencing techniques.

    • Matthew H. Bailey
    • William U. Meyerson
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-27
  • Understanding deregulation of biological pathways in cancer can provide insight into disease etiology and potential therapies. Here, as part of the PanCancer Analysis of Whole Genomes (PCAWG) consortium, the authors present pathway and network analysis of 2583 whole cancer genomes from 27 tumour types.

    • Matthew A. Reyna
    • David Haan
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-17
  • Viral pathogen load in cancer genomes is estimated through analysis of sequencing data from 2,656 tumors across 35 cancer types using multiple pathogen-detection pipelines, identifying viruses in 382 genomic and 68 transcriptome datasets.

    • Marc Zapatka
    • Ivan Borozan
    • Christian von Mering
    ResearchOpen Access
    Nature Genetics
    Volume: 52, P: 320-330