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Rehmannia chingii is a traditional Chinese medicinal plant that can produce iridoid glycoside. Here, the authors report its genome assembly and the elucidation of the iridoid biosynthetic pathway.

Ferromagnetic systems produced by the transition metal doping of semiconductors may be used as components of spintronic devices. Here, a new ferromagnet, Li_1+y(Zn_1-xMn_x)As, is prepared in bulk quantities and shown to have a critical temperature approaching 50 K.

In this work, authors show that deletion of FprB enhances the antibacterial activity of gallium against Pseudomonas aeruginosa, revealing a combination strategy and demonstrating the utility of CRISPRi-seq for therapeutic target discovery.

This study shows that protein kinase A (PKA) drives bone lesions in fibrous dysplasia and that targeting it in mouse models reduces disease severity, highlighting PKA as a promising therapeutic target for fibrous dysplasia.

A microfluidic-based system enables fast screening of Mycobacterium tuberculosis infection through analysis of specific T-cell responses.

Europium halide perovskitoids are new class of lead-free emitters with high efficiency due to symmetry allowed 5d−4f transitions. Here the authors design europium bromides with narrow emission through suppressing electron-phonon coupling.

This study uses deep learning and gaze-tracking to track pathologists' work and learn how they review tissue images. This “learned expertise” was applied to guide artificial intelligence models, such as weakly supervised learning and reinforcement learning, to achieve accurate diagnosis of Whole Slide Images.

Porous graphene integrated into graphene oxide membranes yields smart molecular sieves that switch separation based on the solvent. This allows for graded separations of different-sized molecules.

Two genetically linked TdNLR genes from wild emmer wheat are both required for YrTD121-mediated stripe rust resistance. The TdNLR1 and TdNLR2 pair lacks an integrated ___domain, representing an uncommon architecture for paired NLRs in plants.

Natural variation of the F-box protein ZmFBL41 in maize confers resistance to Rhizoctonia solani, the causal fungus for banded leaf and sheath blight in maize, through decreased interaction of ZmFBL41 with the cinnamyl alcohol dehydrogenase ZmCAD.

The synthesis and isolation of compounds featuring lanthanide–carbon triple bonds remain challenging. Now a cluster featuring a cerium–carbon triple bond has been stabilized inside a C₈₀ fullerene cage. The solid-state structure of the compound reveals a cerium–carbon bond distance of 1.969(7) Å.

The microglia–neuron interactions contributing to neuronal hyperexcitability are unclear. Here, the authors show how GABA and C3 signaling coordinate microglial engulfment of inhibitory synapses, driving excitatory–inhibitory imbalance and neuronal hyperexcitability in epilepsy.

While Bell inequalities have been violated several times—mostly in photonic systems—their violations within particle physics experiments are less explored. Here, the BESIII Collaboration showcases Bell-violating nonlocal correlations between entangled hyperon pairs.

The role of outer mitochondrial membrane proteins in Myocardial Ischemia-reperfusion Injury (MIRI) largely remains unknown. Here, the authors demonstrate that the outer mitochondrial membrane protein Myocardial Mitochondrial Antiviral Signaling (MAVS) protein promotes MIRI suggesting MAVS protein as potential therapeutic target.

Analysis of ancient DNA, stable isotope data and archaeological evidence from the Fujia archaeological site in eastern China suggests it was populated by a matrilineal Neolithic community between 2750 and 2500 bc.

Tailoring the oxygen redox reactivity in Li-rich cathode is crucial for developing high-energy batteries. Here, the authors report a strategy to obtain a flexible crystal structure and enhance the oxygen redox reversibility.

HwMR, a microbial rhodopsin from Haloquadratum walsbyi, thrives in MgCl₂-rich environments and functions as an inward Mg²⁺ transporter, revealed through structural and functional analyses.

Li-rich layered oxide cathodes show high capacities in Li-ion batteries but suffer from structural degradation via O–O dimerization. Here, the authors present local-symmetry-tuned Li₂RuO₃ with oxygen redox involving a telescopic O–Ru–O configuration avoiding O₂ release, enhancing cycling stability.

The authors identified the origin of LiH formation and a new method of LiF formation on a lithium metal anode, which is through the anion decomposition on the cathode side followed by crosstalk.

While the STING-type-I interferon pathway plays a key role in anti-tumour immunity, current direct STING agonists have limited therapeutic benefit. Here, the authors identify ENPP1 as a safer and more effective STING-modulating target than direct STING agonism, and use an AI-based drug design platform to design the ENPP1-selective inhibitor ISM5939.

A dynamic Cu–Pt dual-atom catalyst supported on 1Tʹ-MoS₂ can be electrically switched between single- and dual-atom configurations, enabling on-demand control for alkyne semi-hydrogenation.

A turn-key-operable hybrid integrated Pockels laser based on an external distributed Bragg waveguide grating reflector fabricated in a wafer-scale thin-film lithium niobate on insulator platform is demonstrated, with a tuning efficiency of over 550 MHz V^–1, tuning rates reaching the exahertz per second, and a high output power of 15 mW.

Patients with gastric cancer often present with poor performance status, limiting both quality of life but also treatment options as they are often excluded from clinical trials. Here, the authors report a phase II trial investigating anlotinib (multi-TKI) plus toripalimab (anti-PD-L1 monoclonal antibody) in treatment-naïve advanced gastric cancer patients with performance status 2.

Manipulating the crystal plane via a recrystallization strategy confers lithium metal anodes with much improved diffusion kinetics and mechanical properties, achieving high-energy-density batteries.

Ectoparasites activate prefrontal microglia via the skin–brain axis, damaging GABAergic neurons and reducing host exploration. This limits host distribution and may help ectoparasites avoid environmental pressures.

Analysis of dendrite initiation, owing to filling of pores with lithium by means of microcracks, and propagation, caused by wedge opening, shows that there are two separate processes during dendrite failure of lithium metal solid-state batteries.

Gold redox catalysis is an attractive synthetic method but challenging due to the high redox potential of Au(I)/Au(III). Now, a bidentate N-ligand-assisted gold redox catalysis using H₂O₂ as oxidant has been developed. It can be applied to various coupling reactions, including C(sp)–C(sp) cross-coupling, alkynylative cyclization and bicyclization coupling.

Wastewater treatment plants are important reservoirs of antibiotic resistance genes (ARGs). Here, the authors analyze ARGs in a global collection of samples from wastewater treatment plants across six continents, providing insights into biotic and abiotic mechanisms that appear to control ARG diversity and distribution.

Amines are typically synthesized by aminating organooxygenates with ammonia and noble metal catalysts. Here, the authors reveal the potential of using affordable 3d-transition metal nitrides with nitrogen gas (N₂) as the nitrogen source to produce organonitrogen compounds, offering a new pathway for amine synthesis.

The FDA-approved nanodrug ferumoxytol can relieve reactive oxygen species in haematopoietic stem cells, facilitating their post-injury regeneration.

Diluted magnetic semiconductors are promising spintronic materials, however the simultaneous doping of charge and magnetic moment has prevented synthesis of bulk samples. This work reports the synthesis of a bulk magnetic semiconductor (Ba_1−xK_x)(Zn_1−yMn_y)₂As₂with Curie temperatures up to 180 K.

The high electronic conductivity of solid-state electrolytes leads to Li dendrite growth, thus hindering the commercialization of solid-state batteries. Here, the authors propose a flexible electron-blocking interface to protect garnet electrolytes from the electronic degradation.

Genetic variance is vital for breeding programs and mutant screening, yet traditional mutagenesis methods wrestle with genetic redundancy and a lack of specificity in gene targeting. Here the authors develop a scalable CRISPR system in tomato to edit multiple genes at once, overcoming genetic redundancy and revealing new traits related to fruit quality, nutrient use, and disease resistance.

While CDK4/6 inhibitors have become standard of care in patients with HR+/HER2- advanced breast cancer (ABC), selecting the optimal inhibitor could improve care further. Here, the authors report planned interim analysis of the BRIGHT-2 study, a randomised phase 3 trial comparing bireociclib (CDK4/6i) and fulvestrant (ET) against placebo and fulvestrant in female HR + /HER2- ABC patients.

The activation of C-C bond of benzocyclobutenones under mild reaction conditions remains a challenge. Herein, the authors report a photoinduced catalyst-free regio-specific bond cleavage of benzocyclobutenones, enabling the generation of ortho-quinoid ketene methides for aza-[4 + 2]-cycloaddition with imines. Catalytic asymmetric version is also realized with Ni catalysis.

An asteroseismic and spectroscopic analysis of lithium-rich stars improves their classification based on the distributions of lithium, nitrogen and mass, and reveals that most of these evolved stars are red clump rather than red giant branch stars.

Scrutinizing the dynamic reconfiguration mechanism of intermetallic single-atom catalysts reveals the chemical origin of the enhanced electrocatalysis performance.

Battery cycling induces various changes in the electrode. Here, the authors propose a generalized hypothesis based on metal–metal bonding to rationalize the lattice changes of layer-structured cathode materials including lithium molybdenum trioxide which exhibits abnormal lattice change behaviour.

A ketogenic diet and the ketone body β-hydroxybutyrate are shown to confer resistance to malaria in mice by inducing metabolic reprogramming in Plasmodium parasites, suggesting a dietary strategy for malaria prevention.

Endosomal escape is the major limitation in LNP delivery efficency. Here, the authors report on endosomolytic chloroquine-like lipid nanoparticles for mRNA delivery and genome editing by integrating the chloroquine scaffold into ionizable lipids, demonstrating improved transfection in vivo.