A series of sulfonamides induced the ubiquitin-mediated degradation of the U2AF-related splicing factor, coactivator of activating protein-1 and estrogen receptor α (CAPERα), by promoting direct binding between CAPERα and the CRL4 substrate receptor DCAF15.
- Taisuke Uehara
- Yukinori Minoshima
- Takashi Owa