Search

This study shows how the same brain networks may support resilience differently in individuals with varying genetic risks, enabling more personalized mental health approaches.

The unique properties of self-healing materials hold great potential in the field of biomedical engineering. Here, the authors designed a series of biodegradable and biocompatible self-healing elastomers with tunable mechanical properties, and apply them to various disease models in vivo, including aortic aneurism, bone fracture and nerve amputation.

Aqueous batteries, such as iodide/iodate-based ones, confront challenges due to their low energy densities. Here the authors utilize hetero-halogen electrolytes to enable fast multielectron transfer, yielding high-energy-density aqueous batteries.

Ground state charge transfer is important for improving the photocatalytic performance of donor-acceptor type covalent organic frameworks (COFs), but it has been underexplored. Here, the authors report a COF with enhanced charge transfer, achieving a hydrogen evolution rate of 265 mmol g⁻¹ h⁻¹.

Ammonium ion batteries are of growing interest for energy storage research. Here, the authors observe two-step pseudocapacitive storage behavior in an ammonium acetate electrolyte, resulting in a superior ammonium ion storage capacity.

Limited charge separation is a major challenge in creating efficient semiconductor photocatalysis. This work introduces a superlattice interface and S-scheme heterojunction for ultrafast charge separation and transfer in photocatalytic H₂ evolution.

Genetic resources for livestock are valuable for understanding their demography and past selection, and may inform future breeding programs and agricultural improvement. Here, the authors present deep resequencing of 248 wild and domestic sheep, with associated data and analysis.

Vinuesa et al. identify patients with systemic autoimmunity and a TNIP1 variant that result in dysregulated B cell function. Mice with the orthologous Tnip1 mutation develop spontaneous autoimmunity associated with impaired mitophagy and autophagic silencing of proteins downstream of Toll-like receptor 7 signaling.

Machine learning is a powerful tool for screening electrocatalytic materials. Here, the authors reported a seamless integration of machine-learned physical insights with the controlled synthesis of structurally ordered intermetallic nanocrystals and well-defined catalytic sites for efficient nitrate reduction to ammonia.

This work develops an industrial-level CO₂ electrolysis system for formic acid production by constructing a proton exchange membrane electrolyzer with an acid-tolerant Bismuth metal-organic framework.

MAP1B is bound and regulated by fragile X protein FMRP. Here, the authors show that elevated levels of MAP1B reduce the morphological and physiological maturation of human neurons and impair social behavior in mice.

PIK3CA is a commonly mutated cancer-associated gene, making it an attractive therapeutic target. Here, the authors report the results of a first-in-human phase Ia trial to assess the safety and recommended phase II dose of CYH33, a PI3Kα inhibitor, in patients with advanced solid tumors.

This Case Study describes a 45-year-old white female who was admitted to hospital with a 1-week history of right upper quadrant abdominal pain, progressive tiredness and jaundice. Test results raised concerns that the she had a concomitant acute onset of HCV and autoimmune hepatitis, necessitating liver biopsy. The patient was diagnosed with acute symptomatic infection with HCV genotype 1a with no evidence of autoimmune hepatitis.

This study investigates the Eoarchean Saglek-Hebron rock formation, preserving some of the oldest prebiotic matter on Earth. The findings have implications for Eoarchean abiotic carbon cycling, but also for the geological transformation of precursor biomass on early Earth.

Organic-inorganic lead halide perovskites are a new class of photocatalysts, however, instability and toxicity pose challenges. Here, the authors report a non-toxic all-inorganic Cs₂SnI₆ perovskite anchored with atomically dispersed Pt-I₃ for efficient photocatalytic hydrogen production in hydrogen iodide solution.

The first field test of quantum teleportation is implemented over a 30 km optical fibre network with independent quantum light sources. To establish a robust quantum teleportation system in the real world, several feedback mechanisms are developed.

A genome-wide association study of the human hypothalamus discovers 23 unique loci and examines genetic associations with neuropsychiatric behaviours and disorders.

The seas of the Mesozoic were populated by marine reptiles, yet their modes of locomotion remain unknown. Here, Zhang et al. describe seabed tracks made by the paddles of Middle Triassic nothosaurs in southwestern China, which shows that these marine reptiles used their forelimbs for propulsion.

Three classes of SWI/SNF chromatin remodelling complexes exist in Arabidopsis that differentially regulate chromatin accessibility, gene expression and development.

A study using a reverse genetic screen reveals that the Arabidopsis DREAM complex, including its components TCX5/6, functions as a whole in repressing DNA methylation maintenance genes and, consequently, precluding DNA hypermethylation.

The first field test of quantum teleportation is implemented across a metropolitan fibre network with independent quantum light sources. To establish a robust quantum teleportation system in the real world, several feedback mechanisms are developed.

Loading guests inside the pre-existing pores of nanoporous hosts remains challenging. Here, the authors introduce a rational route for incorporation of guest compounds into an arbitrary nanoporous host, enabling the investigation of multiple host-guest systems with surprising functionalities.

A genome-wide association study of cerebral ventricle phenotypes finds 62 unique loci and reveals a genetic overlap between ventricular and neuropsychiatric traits.

Transposons and repetitive sequences are typically subject to transcription silencing. Here, Zhang et al. find that the bromodomain-containing protein BRAT1 forms a complex with BRP1, recognizes histone acetylation and acts to prevent transcriptional silencing in Arabidopsis.

Rewritable paper is environmentally favourable, but its practical realization is stifled by limited ink colour versatility and poor image retention times. Here, the authors exploit the relatively stable but reversible nature of metal–organic coordination bonds to produce long-lasting and multicoloured inks for rewritable paper.

Across cancer types tumor heterogeneity has been observed, but how this relates to tumor evolution is unclear. Here, the authors sequence multiple synchronous lung cancers, highlighting the evolutionary pressures that simultaneously shape the expansion and constraint of genomic heterogeneity.