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Chronic wounds typically exhibit dynamic variations within the complex wound microenvironment over time. Here, Cheng et al. develop a microenvironment-feedback hydrogel to achieve homeostatic wound pH and blood glucose levels to accelerate repair of diabetic chronic wounds.

The genetic basis underlying resistance to Sclerotinia stem rot (SSR) in oilseed rape remains elusive. Here, the authors identify BnaA07.MKK9 as a pivotal regulator of SSR resistance in oilseed rape by GWAS, providing new insights into plant defense mechanisms against necrotrophic pathogens.

The authors propose a design that equips a programmable metasurface with integrated capability for sensing and manipulating electromagnetic waves, allowing it to leverage the environmental information to enhance wireless system performance in complex environments.

Neural circuit mechanisms that regulate the panic-like defensive state are not fully understood. Using a robot-based experimental paradigm, the authors identify Cbln2-expressing (Cbln2+) neurons in the mouse posterior hypothalamic nucleus (PHN) as a key neuronal population essential for the induction of panic-like defensive state.

White-light emission from materials and devices usually occurs omni-directional through space. Here, the authors show that sintering carbon dots with TiO₂ forms a microlens-shape surface that enables directional emission with 1/60 solid angle.

Real-time ray tracing faces significant computational hurdles on electronic platforms. Here, authors present the first thin-film lithium niobate photonic circuit for ray tracing acceleration, enabling rapid, energy-efficient ray-box tests with a 1-bit ADC, achieving 326 fJ/OP and over 100 GHz bandwidth.

A study examines the effects of mutations that occur naturally in T cell cancers, reporting that such mutations can potentially be exploited to increase the potency of T cell therapies.

A reinforcement learning-based virtual reality system, implementing a series of sport sessions with coaching, was as effective as standard physical activity in reducing fat mass in adolescents, with positive effects on cognition.

Wu et al. show that glucosamine acts as a P-glycoprotein activator, rapidly enhancing intestinal drug efflux and reducing drug absorption. The authors propose this as a detox strategy to improve survival outcomes following paraquat exposure.

Particle bombardment is a widely used tool for plant genetic engineering, but its low efficiency has been a bottleneck since its commercialization. Here, the authors design a flow guiding barrel to modulate particle and gas flow dynamics inside the gene gun and show its ability to enhance plant transformation efficiency.

Clear cell renal cell carcinoma (ccRCC) usually metastasizes to the lungs. Here, the authors discover that SWI/SNF ATPase subunit SMARCA4 silencing of HLF regulates ccRCC lung metastasis by modulating the integration of collagen's mechanical cues with the actin cytoskeleton through leupaxin.

The methyltransferase OsPRMT6b is found to act as an ABA responsive factor to finely turn down ABA signaling via methylation of ABA receptor, thus facilitating growth recovery as high-temperature stress subsides.

Self-injection locking of an on-chip laser to a milimetre-scale vacuum-gap Fabry–Pérot cavity is demonstrated, with a phase noise of –97 dBc Hz^–1 at a 10-kHz offset frequency and a fractional frequency stability of 5 × 10⁻¹³ at 10 ms, enabling next-generation high-performance integrated systems.

Fa-Cheng Wang and colleagues propose a conceptual hybrid design for submerged floating tunnels (SFTs) that considerably improves resistance to harsh service conditions. This adaptable and cost-effective solution advances SFT practical implementation.

The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.

The connection between plasma proteomic and brain structure remains unclear. Here, the authors establish a comprehensive atlas of the patterns of associations between microscale proteome and brain structure, and demonstrate their potential value for studying brain disorders.

The mechanisms whereby METH yields strong addiction potential is not fully understood. Here, authors show that METH may impair the function of the endogenous OXT system, particularly the PVN^OXT-NAc core pathway, suggesting OXT-based therapies for METH use disorder (MUD).

Sphingosine-1-phosphate receptor 1 (S1PR1) is a drug target for inflammatory bowel disease (IBD), impacting immune cell movement, but current treatments carry immunosuppression risks. Here, the authors show that a Gi-biased S1PR1 agonist, SAR247799, protects the endothelial barrier in IBD models without affecting immune cell egress, offering a potential new treatment strategy.

Tu, Qian et al. identify BAZ2B as an epigenetic regulator of hepatocyte senescence, linking liver aging to metabolic dysfunction-associated steatohepatitis through PPARα and lipid metabolism.

CRISPR-based detection has long been challenged by the separation of amplification and detection steps. In this study, Cheng et al., show that heparin sodium modulates Cas12 cleavage activity and apply a one pot system to detect clinical influenza A virus and SARS-CoV-2 in wastewater.

Tear secretion from lacrimal gland is essential for ocular health, but the regulatory role of sympathetic nervous system is unclear. The authors show that sympathetic activation suppresses lacrimal tear secretion and aggravates dry eye disease via NA–Adra1a–Ucp2 signaling.

The role of mucosal-associated invariant T (MAIT) cells in liver injury is elusive. Here the authors identify that MAIT cells frequency and TCR activation are associated with degree of liver injury and prognosis of liver transplantation.

This Review introduces state-of-the-art vibrational microscopy for research in the life sciences and offers guidance for prospective users.

Catalytic asymmetric click reactions of azides and alkynes for chiral triazole synthesis remains a challenge, due to the limited catalytic systems and substrate scope. Herein, the authors report the enantioselective azidation/click cascade reaction of N-propargyl-β-ketoamides via copper catalysis, affording a variety of chiral 1,2,3-triazoles.

Although aryl triflates are essential building blocks in organic synthesis, the applications as aryl radical precursors are limited. Here, the authors report an organomediated electrochemical strategy for the generation of aryl radicals from aryl triflates, providing a method for the synthesis of aryl sulfonyl fluorides from feedstock phenol derivatives under very mild conditions.

A high-κ dielectric ceramic, magnesium niobate, can be epitaxially grown on a mica substrate and then transferred to form the gate dielectric in molybdenum disulfide transistors, providing van der Waals interfaces and high robustness to temperature and voltage.

The instability of quantum dot inks hinders the scaling up of colloidal quantum dot electronics. Now, Shi and team stabilize the inks with an iodine-rich environment in a weakly coordinating solvent, achieving 13.4% in small-area solar cells and over 10% in modules.

A computational framework to integrate microbial GWAS and single-cell RNA-sequencing profiles of 24 human organs reveals interactions between the host cells and microbes.

Low-frequency quasiperiodic oscillations in X-ray data are thought to trace the accretion flow in X-ray binaries. Here, the detection of 200 keV oscillations probes the innermost regions of MAXI J1820+070, revealing the precession of a small-scale jet.

Spatiotemporal beams differ from standard spatial structured light. The authors introduce 2D spacetime duality to uncover the conventional–spatiotemporal beam connection, enabling the development of high-fidelity spatiotemporal beams.

The Mizoroki–Heck reaction and its reductive analogue are staples of organic synthesis, but the ensuing products often lack a chemical handle for further transformation. Here the authors present a method to add a heterocycle and transformable halide across a double bond via iridium photocatalysis.

The design of host-guest systems for switchable recognition of guests upon the change of external stimuli is challenging due to the invariable host-guest affinity. Here, the authors encode a dynamic motion into a porous crystal to regulate the diffusion of CO2 and C2H2 allowing the crystal to switch the gas recognition selectivity by temperature.

The Newtonian gravitational constant is measured with two independent methods, yielding results with relative standard uncertainties of 11.6 parts per million—the lowest uncertainty reported until now.

Genome-wide association studies (GWAS) have improved our understanding of the genetic basis of lung adenocarcinoma but known susceptibility variants explain only a small fraction of the familial risk. Here, the authors perform a two-stage GWAS and report 12 novel genetic loci associated with lung adenocarcinoma in East Asians.

The authors report a stretchable and integrated energy harvest-storage-application skin-adherent microsystem, by utilizing an all-in-one MXene film simultaneously as micro-supercapacitors, wireless receiver coils and strain sensors.

Metallocene-based phosphines are compounds with potential use in catalysis. Here, the authors report the electrochemical regioselective functionalization of group 8 metallocenes with phosphine oxides; over 60 examples of phosphorylated (benzo)ferrocenes and ruthenocenes can be accessed via this method without the need for a preinstalled directing group.

There are very few methods for the organocatalytic aziridination of unactivated olefins. Here the authors report a simple ketone catalyst for the transfer of nitrogen to isolated carbon–carbon double bonds, with good substrate scope and in high yields.

This study proposes an integrated sensing and communication (ISAC) scheme leveraging space-timecoding metasurfaces (STCMs), which enables concurrent wireless communication and sensing on a shared platform.

Fibroblasts are found to be heterogeneous in multiple fibrotic diseases, but fibroblast heterogeneity in fibrotic skin diseases is not well characterized. Here the authors employ scRNA-seq to explore fibroblast heterogeneity in keloid, a paradigm of fibrotic skin diseases.