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Li et al. report free-standing layered polymer–perovskite composite membranes that reconcile mechanical flexibility with electronic properties. They endure 30,000 bends at a 1.5 mm radius, enabling wearable radiation monitoring in complex conditions.

The methyltransferase OsPRMT6b is found to act as an ABA responsive factor to finely turn down ABA signaling via methylation of ABA receptor, thus facilitating growth recovery as high-temperature stress subsides.

It is generally more difficult to modify the buried interfaces compared to top interfaces in tin-lead perovskite subcells. Here, the authors employ a mercapto-functionalized mesoporous silica layer as a superstructure, realizing maximum efficiency of 29.6% for double-junction tandem solar cells.

Preclinical studies have shown synergy in the combination of tifcemalimab (anti-BTLA antibody) with toripalimab (anti-PD-1 antibody) in lymphoma. Here, the authors report a clinical trial investigating tifcemalimab alone and in combination with toripalimab in patients with relapsed or refractory lymphoma.

In large prospectively enrolled validation cohorts of patients with cancer and controls and a prospective study of asymptomatic individuals with average risk for cancer, a multicancer early detection test based on plasma cell-free DNA genomics and fragmentomics showed encouraging accuracy in identifying ongoing disease as well as the tissue of origin.

Human NPCs show promise for stroke treatment, but challenges remain in neuron diversity and maturation time. Here, the authors describe the generation of FOXG1 progenitors from iPSCs that quickly mature into functional cortical neurons, enhancing stroke recovery in rats.

Nonalcoholic fatty liver disease (NAFLD) has limited dietary treatment options. Here, the authors show that torularhodin, a microbial carotenoid, alleviates NAFLD by enriching Akkermansia muciniphila and promoting adenosylcobalamin synthesis, which reduces ceramides via HIF-2α inhibition.

LipidIN is an advanced framework designed for flash platform-independent lipid annotation. Featuring a comprehensive 168.5-million lipid fragment library with the intelligent models, LipidIN improves annotation accuracy, speed, and coverage.

A selective shielding strategy achieves the differentiation and quantification of distinct plasmonic photocatalytic mechanisms including hot carrier-driven photochemistry, resonant field-mediated energy transfers, and thermal contributions.

The immune checkpoint B7-H4 is regulated through post-translational modifications. Here, the authors identify that in breast cancer cells ZDHHC3-catalyzed B7-H4 palmitoylation prevents its lysosomal degradation and maintains immune suppression, which can be targeted by Abemaciclib to enhance lysosome activation independently of CDK4/6 inhibition.

Combination immunotherapy with anti-PD-1 and anti-LAG-3 antibodies has shown anti-tumor effects across various cancers, however not all patients respond. Here the authors report that resistance to anti-LAG-3 plus anti-PD-1 therapy in head and neck cancer is mediated by the interaction of Sox9+ tumor cells with Frp1+ neutrophils, resulting in impaired anti-tumor immunity.

Instability is a key challenge in aqueous sodium-ion batteries. Here, authors propose a Na-rich birnessite with high Na content and minimal Mn defects, suppressing Mn migration and its accompanying domino degradation effect, which enables a wide potential window and improved structural stability.

The exploration of heterogeneous interfaces between metal oxides has received limited attention. Here the authors demonstrated the creation of MnO₂-Mn_xCo_3-xO₄ interfaces through controlled chemical reduction processes, effectively altering electron distribution and yielding a superior catalyst for ethane oxidation.

LC-MS-based proteomics often relies on data-dependent acquisition (DDA) for quality control. Here, the authors demonstrate that data-independent acquisition (DIA) outperforms DDA in detecting subtle changes in LC-MS status in large-scale quantitative proteomics experiments. They further prioritized 15 QC metrics and developed an AI model, implemented in a free software called iDIA-QC, for detecting LC-MS faults.

Succinylation of PD-L1 by carnitine palmitoyltransferase 1A (CPT1A) in melanoma leads to its degradation and enhanced T cell-dependent killing in vitro. Increasing CPT1A levels synergizes with anti-CTLA-4 treatment to suppress tumor growth in a mouse melanoma model.

Renal tubular atrophy is a hallmark of chronic kidney disease. The study by Zhu et al. reveals the protective role of tubular polynucleotide phosphorylase (PNPT1) against renal atrophy by blocking the leakage of mitochondrial dsRNAs into cytoplasm where they activate the PKReIF2α axis and terminate translation.

MEMS gravimeters are compact and cost-effective but face challenges in achieving ultra-high sensitivity due to fabrication tolerances and size limitations. Here, authors introduce a μGal MOEMS gravimeter with locally adjustable free-form anti-springs, achieving picometer-level displacement sensitivity.

Wang et al. demonstrate that the vascular smooth muscle cell–dependent expression of TRPM7, an ion channel with kinase function, increases the levels of calcium and zinc and, thus, increases the MMP2 activity and contributes to the formation of abdominal aortic aneurysm.

Despite recent progress in individual nanocluster synthesis, understanding the competing or coexisting effects between particles in solution remains challenging. Here, the authors present the synthesis of a bi-nanocluster system comprising two atomically precise nanoclusters, and map out the interdependent relationship between them.

Aryl hydrocarbon receptor (AHR) is an emerging immune-related drug target. Here, the authors report the crystal structures of AHR with six agonists bound, revealing the molecular mechanisms of diverse ligand binding and allosteric activation of AHR.

C-aryl glycosides are present in many natural products and of interest in drug design, but their chemical synthesis is challenging. This work reports an efficient and diastereoselective ortho-directed C−H glycosylation of arenes and heteroarenes with glycosyl chloride using a palladium catalyst.

It remains essential to find clinically relevant biomarkers in epithelial ovarian cancer (EOC). Here, the authors perform a comprehensive proteomic profiling of tissue and plasma samples from EOC and control patients; they find potential biomarkers for EOC early detection and develop methods for tumour recurrence prediction.

Despite the considerable potential of single-atom catalysts in water and wastewater treatment, large-scale production is still challenging. A multidimensional coordination approach provides a practical and cost-effective method for the mass production of single-atom catalysts.

Safety is only one side of the coin for aqueous batteries. Here the authors show a water-in-polymer electrolyte that shows a wide electrochemical window and salt recyclability, thus addressing challenges at the other side.

Creating and maintaining a superior microenvironment is challenging for electrocatalytic CO₂ reduction reaction. Here the authors report an in situ activation method to deliver silver nanoparticles within the gas diffusion layer, constructing a feasible and stable interfacial microenvironment.

By characterizing the dynamics of epitranscriptomes and translatomes upon Magnaporthe oryzae infection, the authors uncover that ac4C enriched in the 3rd nt of codons improves translation of mRNA to enhance rice resistance against M. oryzae.

Emerging organic contaminants (EOCs) are difficult to remove from complex water systems, but photo-Fenton-like reactions offer a promising solution. Here, the authors develop Cu single-atom loaded covalent organic frameworks to reduce excitonic effects and enhancing radical generation thereby improving EOCs degradation.

The spread of many infectious diseases substantially relies on aerosol transmission to the respiratory tract. Here, the authors design an intranasal mask with the ability to intercept viral aerosols, entrap and inactivate virus, thus preventing respiratory tract infection.

Here, the authors develop a non-antibiotic approach using sonodynamic therapy mediated by a lecithin bilayer-coated poly(lactic-co-glycolic) nanoparticle preloaded with verteporfin, Ver-PLGA@Lecithin, to treat Helicobacter pylori.

Inspired by the idea of mimicking virus entry to host cells and macrophage-mediated virus clearance, the authors developed a lysosomal “TRAP”, which could efficiently capture, internalize, and degrade viruses and variants.

Acquired radiation resistance in residual tumours impedes the therapeutic outcome of re-irradiation. This study reports a novel radiosensitization strategy that targets cuproptosis to overcome resistance and enhance antitumour effects.

Hyperactivation of ribosome biogenesis (RiBi) causes excessive ribosome production, contributing to genome instability and cancer progression. The authors investigate the role of RiBPs in breast cancer, highlighting the upregulation of factors like DCAF13, which enhances cell proliferation by regulating Pol I transcription via K63-linked ubiquitination of RPA194.

Exploring low-cost, efficient catalysts to replace platinum is crucial for electrocatalytic hydrogen generation. Here, the authors report a termination-acidity strategy that boosts the activity of molybdenum carbides, achieving a low overpotential and sustaining hydrogen generation for over 200 h.

Two-dimensional topological insulators support edge conduction electrons but its realization in real materials is rare. Here, Peng et al. report the direct observation of topological states at the step edge of WTe₂.

The authors report a computational strategy to simulate the hydrolysis and ammonolysis of N₂O₅ in aerosols using high-level quantum chemical methods. The computational results reveal a complete picture of the reactive uptake of N₂O₅ by atmospheric aerosols with or without NH₃.

Age-dependent decline in remyelination in the CNS is associated with declined differentiation capacity of oligodendrocyte progenitor cells (OPCs). Here, the authors show nuclear entry of SIRT2 is impaired and NAD+ levels are reduced during ageing in mouse OPCs. β-nicotinamide mononucleotide (β-NMN) supplement delays myelin aging and enhances remyelination in the aged mice.

Macrocyclization is an important process in bioactive natural product synthesis. Here, the authors report on the study of a macrocyclic ring constructing enzyme in the biosynthesis of alchivemycin A and using gene deletion, biochemical assays and isotope labelling show the enzyme catalyses tandem dehydration and Michael-type addition.

Size control in quantum materials by direct growth is still difficult to achieve. Here, the authors present the width-dependent growth of single-layer nanoribbons of transition metal dichalcogenides from nanoalloy seeds, achieving strain-induced quantum emission with a purity of up to 90 % for single photons.

The mechanism underlying thyroid follicle formation is not well understood. Here, the authors show that a subgroup of NF-κB-activated thyrocytes, through interactions with myeloid cells, exhibit increased migration capacity to generate new follicles.