Search

The immunomodulatory functions of mast cells (MCs) within the tumor microenvironment are elusive. Here, the authors present a transcriptomic characterization of LUAD-infiltrating MCs and identify a proinflammatory subset that contributes to the activation of cytotoxic MAIT cells by secreting IL-18 via NRLP3 activation and pyroptosis, ultimately boosting anti-tumor immunity.

T-cell enrichment has attracted great interest but currently fails to fully replicate the complex natural immune interactions. Here, the authors report on magnetic polymerised antigen-presenting cells that mimic natural interactions to isolate rare tumour-reactive T cells, offering a platform for enhancing cancer immunotherapy and neoantigen discovery.

Penketh et al. develop an approach for mapping the frequency response of thousands of meta-atoms in a microwave metasurface simultaneously, leading to the formation of detailed hyperspectral images. The approach – applicable to a wide range of metasurfaces – may overcome fabrication challenges for translation of such metasurfaces to real-world devices.

A preinfusion circulatory inflammation biomarker-based signature predicts the likelihood of treatment failure in patients with non-Hodgkin lymphoma who were treated with CAR-T cell therapy, with an inflammatory cluster assignment being prognostic of clinical response and survival outcomes.

The authors present cryo-electron structures of human VANGL1, VANGL2 and their complexes with PK1, unveiling the molecular underpinnings of the VANGL-PK interaction and paving the way for future investigations into the planar cell polarity pathway

Heterogeneous single-atom catalysts (SACs) offer high atom utilization and well-defined active sites but face challenges in multi-stage cross-couplings due to limited coordination and reactivity. Here, the authors introduce SACs on reducible carriers, enabling adaptive coordination to bypass oxidative addition in cross-couplings.

Mai and colleagues present cryo-electron microscopy structures of the SPG11–SPG15 and AP5–SPG11–SPG15 complex, offering insights into mechanisms of autophagic lysosome reformation and retrograde trafficking.

Cryo-electron microscopy structures of native type A GABA receptors from human brain reveal diverse subunit compositions, protein binding partners and binding sites for antiepileptic drugs.

Gorman et al. designed a Lassa virus prefusion-stabilized soluble glycoprotein complex trimer (GPC), with which they identified a Lassa virus-neutralizing nanobody that bound the GPC apex and elicited neutralizing antibody responses in guinea pigs.

Membrane fouling during electrodialysis, nanofiltration and ultrafiltration processes results in a reduction in the dye/salt fractionation efficacy. Here, authors devise an electro-driven filtration process using tight ion-conductive ultrafiltration membrane for one-step, stable dye/salt fractionation.

Balancing information security and sharing remains a significant challenge. The authors propose and demonstrate PS-DNNs that capable of high-security data exchange, which unify both information sharing and security within an all-optical framework.

FeGe is an antiferromagnetic kagome metal with a rich magnetic and electronic phase diagram. Recently it was found that post-growth annealing of FeGe can suppress or induce charge density wave order depending on the annealing temperature. Here, Klemm, Siddique et al show the critical role that annealing induced Ge-vacancies and stacking faults play in the formation of charge density wave order in FeGe.

The authors develop a strategy to regulate oxygen reduction reaction kinetics and electron lifetimes with coordinatively unsaturated FeOOH and CoO_x clusters to access a direct two-electron pathway for H₂O₂ photosynthesis on boron-doped g-C₃N₄.

While CDK4/6 inhibitors have become standard of care in patients with HR+/HER2- advanced breast cancer (ABC), selecting the optimal inhibitor could improve care further. Here, the authors report planned interim analysis of the BRIGHT-2 study, a randomised phase 3 trial comparing bireociclib (CDK4/6i) and fulvestrant (ET) against placebo and fulvestrant in female HR + /HER2- ABC patients.

Quantum interference among elementary Raman processes has only been observed in few materials under specific excitation configurations. Here, the authors show that quantum interference can lead to significant chiral Raman response in a monolayer material of transitional metal dichalcogenide with triclinic symmetry.

3D electron crystallography enables structure determination of submicron-sized crystals, but obtaining complete data is difficult due to preferred orientations. Here the authors develop sample supports that allow sampling nanocrystals with full data completeness, and demonstrate this with ZSM-5 zeolites.

The researchers present a scalable Tamm plasmon cavity using phase change material with large resonance tunability and demonstrated tunable SERS by matching the plasmonic resonance with the molecule absorption for sensitivity enhanced biosensing.

Middle-aged individuals are more susceptible to obesity, but the mechanisms are unclear. Here, the authors show that extracellular vesicles from adipose progenitor cells in middle-aged individuals lack miR-145-5p, driving inflammation, and that restoring miR-145-5p could prevent midlife obesity.

The purification of ethylene is an industrially relevant process. Here, the authors report the one-step separation of ethylene from quaternary gas mixtures of hydrocarbons and CO₂ using a single metal–organic framework-based physisorbent.

Methaqualone (Quaalude) is an infamous sedative-hypnotic, used in the past for treatment of insomnia. Here, the authors use structural biology and electrophysiology to elucidate its mechanism of action at its primary target, the GABA_A receptor.

Rooftop photovoltaic systems are often seen as a niche solution for mitigation but could offer large-scale opportunities. Using multi-source geospatial data and artificial intelligence techniques, the authors map their potential for reducing global temperatures and analyse regional differences.

The ultraviolet-assisted intercalative oxidation of high-mobility two-dimensional semiconductor Bi₂O₂Se can be used to create a single-crystalline native oxide dielectric—β-Bi₂SeO₅—that can yield top-gated transistors with an equivalent oxide thickness of 0.41 nm.

WS₂ is a promising material for application in next-generation electronics, yet current methods of fabrication can only yield micrometre-sized domains. Here, via ambient-pressure CVD, the authors report the growth of high-quality, uniform monolayer WS₂single crystals of the order of millimetres.

Understanding the effect of grain boundaries on the electrical and thermal transport properties of graphene is of both fundamental and technological importance. Here, the authors fabricate graphene films with controlled grain size, and determine the scaling laws of thermal and electrical conductivities.

Calcium signalling is an essential feature of T cell activation. Here authors employ CaCO₃ nanoparticles to facilitate the expansion and cytotoxic function of therapeutic T cells via enhanced intracellular release of calcium.

Here, the authors develop a plasmon-free SERS platform based on two-dimensional MnPS₃ with sub-attomolar detection limit. Their strategy is based on a mechanochemical approach that combines wrinkling and chemical functionalization to boost SERS performance, making it relevant for biosensing.

Early-onset lung cancer in young adults remains poorly studied. Here, the authors analyse the clinicopathological, molecular, and immune features of early-onset non-small cell lung cancers in a cohort of 421 patients across ten medical centres in China, identifying potential therapeutic strategies for this subgroup.

Hydrogen isotope exchange is essential for the synthesis of deuterium-labeled compounds but remains challenging under mild conditions. This study demonstrates the selective deuteration of alkylarenes at room temperature using atomically dispersed surface barium hydride.

The design of high energy density materials (HEDM) with good detonation performance but which are also safe to handle is challenging. Here, the authors synthesize a PTX analogue and incorporate explosophoric groups to obtain an HEDM with improved detonation performance but low impact and friction sensitivity.

Defects in a crystalline solid can have a dramatic effect on the material’s properties. Here, the authors demonstrate a class of defects in two-dimensional transition metal dichalcogenides mediated by chalcogen vacancies and inherently related to the crystal symmetry

Legesse et al. present structural studies of a human GABAA receptor in complex with positive and negative modulator neurosteroids, uncovering mechanisms of potentiation and inhibition.

Xenon binding carries potential for xenon separation and emerging applications in magnetic resonance imaging. Here, the authors report a rare example of a tight yet soft capsule, assembled from two chiral bisurea-bisthiourea macrocycle components, that can efficiently and adaptively bind xenon in both the solid state and solution.

The cryo-electron microscopy structure of the type A GABA receptor bound to GABA and the benzodiazepine site antagonist flumazenil reveals structural mechanisms that underlie intersubunit interactions and ligand selectivity of the receptor.

Huang et al. investigated the effects of long-term statins administration in a mouse model for diabetes and found that it can worsen insulin resistance, renal inflammation and fibrosis. Statins increased renal lipid uptake and inhibited fatty acid oxidation, contributing to diabetic nephropathy.

The controlled manipulation of the topological phases of electronic materials is a central goal of modern condensed matter research. Here, the authors demonstrate controllable switching between two distinct topological phases in a layered ferromagnet via thermal cycling.

Here the authors use a structural approach to reveal how neuromuscular blockers and a general anesthetic antagonize the muscle-type nicotinic receptor through competitive and allosteric mechanisms.

A reservoir computing system for multimode and multiscale signal processing can be created using optoelectronic synapses that are based on α-In₂Se₃ and exploit the tightly coupled ferroelectric and optoelectronic properties of the material.

Kdm2a demethylates H3K36me2 to mediate fast-to-slow-twitch myofiber transition and reshape skeletal muscle metabolic flexibility under metabolic stress conditions.

GABA_A receptors are important targets for anxiety, sedation and anesthesia. Here, the authors present structures bound by zolpidem (Ambien), the most prescribed hypnotic in the US, and DMCM, a negative modulator, providing insights into receptor modulation.

Niobium oxide memristors with reconfigurable dynamics can be used to make an array integrated with phototransistors that can encode image information in analogue or spiking form and can support different neural network architectures for image processing tasks.

Large lattice variation of electrode materials upon lithiation and delithiation limits the cycle life of lithium batteries. Here, authors introduce a lattice pinning strategy via heterostructure design to suppress lattice expansion in MoO₃ and improve cycle life in all-solid-state lithium batteries.

Bacterial populations, programmed to self-assemble by adhesion of nanobody–antigen pairs, can be processed into living materials (LAMBA) that are scalable, self-healing and programmable through functionalization with diverse proteins.

Here the authors reveal the structural basis of how the nicotinic acetylcholine receptor type found on skeletal muscle and in fish electric organs desensitizes in response to agonist and how the arrow poison curare antagonizes the channel by stabilizing a desensitized state.

Achieving bright and efficient blue emission in metal halide perovskite light-emitting diodes has proven to be challenging. Here, the authors demonstrate high EQE and spectrally stable blue light-emitting diodes based on mixed halide perovskites, with emission from 490 to 451 nm by using a vapour-assisted crystallization technique.

SERS spectroscopy critically relies on the accumulation of analyte molecules in electromagnetic ‘hotspots’. Here, the authors demonstrate plasmonic trimers with central particles that act as chemical traps, enabling the subtyping of lung tumors using fresh tissue samples.

AMBRA1 functions as a substrate receptor for E3 ubiquitin ligase complexes to promote ubiquitination and degradation of Cyclin D. Here the authors demonstrated the structure of AMRBA1 in complex with DDB1. Disruption of intermolecular interactions caused deregulation of cell cycle and DNA damage repair.