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R9AP is a key receptor for entry of Epstein–Barr virus into human epithelial and B cells, and interacts directly with the viral glycoprotein gH/gL complex to mediate virus–host membrane fusion.

Gloeobacter diverged from other lineages early in cyanobacterial evolution, preferentially growing under low light intensity conditions. Here, the authors describe cryo-EM structures of PBSs from G. violaceus cells cultured under low or moderate light intensity.

Lan et al. demonstrate the high performance of plasma p-tau217 in detecting and tracking multiple aspects of Alzheimer’s disease pathology, outperforming other plasma tau biomarkers across two Chinese cohorts (GHABS and Huashan) and the North American ADNI cohort.

On-target, off-tumour toxicity is a major concern in immunotherapy. Here, aided by computer docking analysis, the authors introduce a single oxygen atom into the TLR7/8 agonist R848, generating a radiotherapy-activatable prodrug agonist that in mice helps mitigate systemic toxicity while triggering effective anti-tumor immunity responses upon radiation.

The heart relies on fatty acid oxidation as its main energy source. Here they show that impaired fatty acid metabolism disrupts mitophagy in the heart and that enhancing mitophagy via USP30 inhibition can restore heart function in models of fatty acid oxidation deficiency.

The genetic basis underlying resistance to Sclerotinia stem rot (SSR) in oilseed rape remains elusive. Here, the authors identify BnaA07.MKK9 as a pivotal regulator of SSR resistance in oilseed rape by GWAS, providing new insights into plant defense mechanisms against necrotrophic pathogens.

Artificial intelligence-based detection of gastric cancer at different stages from noncontrast computed tomography is suggested to be feasible in a retrospective analysis of large and diverse cohorts, including real-world populations in opportunistic and targeted screening scenarios.

Prostate cancer is heterogenous in response to therapy. Here, the authors analyse genomics, transcriptomics, proteomics and phosphoproteomics data from 145 prostate cancer patients to identify NANS as a therapeutic target in prostate cancer.

The oxygen reduction reaction (ORR) is limited by the scaling relationship in the conventional oxygen associative pathway. In this study, single p-block atoms and interstitial H are incorporated into Pd metallenes favoring the direct dissociation mechanism, leading to high alkaline ORR performance.

Species’ traits and environmental conditions determine the abundance of tree species across the globe. Here, the authors find that dominant tree species are taller and have softer wood compared to rare species and that these trait differences are more strongly associated with temperature than water availability.

Indian dwarf wheat (Triticum sphaerococcum) is thermotolerant, but the underlying mechanism is unclear. Here, the authors report the cloning of the heat tolerance gene encoding a STKc_GSK3 kinase and its variation affects phosphorylation level of downstream TaPIF4 in determining thermotolerance.

Neural networks fundamentally dictate function. Here, the authors show thirteen uniquely connected neuron populations within the anterior thalamic nuclei, suggesting multiple parallel subnetworks support its emotional and cognitive functions.

Genetic basis of the drought tolerance of upland rice is unclear. Here, the authors report the cloning of a COBRA-like protein encoding gene DROT1 and reveal that it is repressed by ERF3 and activated by ERF71 to help control the balance between growth and drought tolerance in upland rice.

Here the authors report asperigimycins, fungal ribosomally synthesized and post-translationally modified peptides with a heptacyclic scaffold. After chemically modifying them for nanomolar anticancer activity, CRISPR screening identifies SLC46A3 as a key transporter for their uptake in cells.

Wang et al. profile mitochondrial RNA across 47 human tissues from 838 individuals, observing that mitochondria keep two different aging clocks: proliferative tissues accumulate many random mutations, whereas nondividing tissues progressively acquire recurrent hotspot mutations.

Electronic metal-support interaction within Pd/TiO₂ are optimized for photocatalytic H₂O₂ evolution and furfural oxidation to furoic acid, realizing the simultaneous utilization of photogenerated electrons and holes for dual value-added products.

Fan et al. show that cTAGE5 is essential for adipogenesis and adipose tissue development. Mechanistically, cTAGE5 promotes pro-insulin receptor processing, which mediates actin cytoskeleton remodeling and lipolysis during the adipocyte differentiation.

Clarke et al. presents a framework for spatial analysis of the metabolome, lipidome, and glycome from a single tissue section using mass spectrometry imaging. Applying this approach, they revealed region-specific metabolic diversity and dysregulation in both normal and diseased mouse brains.

Integrated optical frequency combs are powerful tools for optical spectroscopy. Here, authors demonstrate low-power, detectable-rate soliton microcombs from telecom to visible bands, including wavelength-multiplexed operation, using ultra-low-loss silicon nitride waveguides.

Aberrant activation of autoreactive T cells is a hallmark of autoimmune diseases. Here, by analysing CD4 T cells from patients with polymyositis and mice with experimental autoimmune myositis, the authors show that TIGIT limits the differentiation of inflammatory Th1 and Th17 cells via a metabolic-epigenetic mechanism, which involves the inhibition of CD28-mediated PI3K/AKT/mTOR costimulatory signaling.

A novel covalent inhibitor, ISM3312, targets the main protease of multiple human coronaviruses, including drug-resistant strains, and shows broad antiviral activity. It offers a promising therapeutic strategy against current and future coronavirus threats.

Traditional lithographic techniques could damage organic semiconductor crystals due to high-energy beams or solvents. Here, authors employ a chemical-free nanoimprint crystallography method for fabrication of independent complex 2D patterns that exhibit good lasing performance and reproducibility.

Active radiant cooling is an emerging technology that consumes less energy than traditional air conditioning. This work demonstrates an outdoor radiant cooling structure incorporating infrared-reflective surfaces that delivers enhanced thermal comfort.

Xiao, Dong, Xie, Feng et al. developed FRα-targeting chimeras (FRTACs) for targeted membrane protein degradation by conjugating multiple folate molecules to antibodies of targeted proteins. The folate polyvalency of FRTACs enables high affinity and potency of FRTACs in eliminating target proteins.

The immune response of immunotherapy in colorectal cancer remains low and new adjuvant targets are in demand. By in vivo CRISPR-Cas9 screening that targets membrane and secreted proteins genes, the authors identify that disrupting MBTPS1 in tumor cells upregulates STAT1-transcribed chemokines, promotes CXCR3⁺ CD8 T cells infiltration and potentiates anti-PD-1 therapy.

The introduction of 3TPYMB, an n-type molecule into inverted perovskite solar cells, enables a power conversion efficiency of 25.6%, with devices maintaining up to 98% of the initial efficiency after 1,800 h of operation.

The authors make a terahertz device utilizing collective electronic states in 1T-TaS₂ that achieves reconfigurable logic operations through dynamic charge-density-wave phase manipulation. The device shows exceptional performance metrics and enables secure multicolor recognition for next-generation encrypted communications.

Lattice distortion in electrode materials often results in battery degradation. Here, the authors exploit a cooperative Jahn-Teller effect in a MnO2/graphene superlattice to create strain-relieving structures, improving cycling stability in aqueous zinc-ion batteries.

ctDNA is a promising method to monitor tumor burden in triple negative breast cancer. Here, the authors show that ctDNA detection correlated with prognosis after neoadjuvant chemotherapy but not at baseline.

Lampreys are jawless vertebrates that can offer unique insights into vertebrate evolution. Here they generate a comprehensive cell atlas of the lamprey, uncovering 70 distinct cell types across 14 tissues, and identify pancreas-like cells in the lamprey small intestine.

Chromatin topology can impact gene regulation. Here, Wu et al. show that evolutionary changes in chromatin structure, particularly CTCF loops, can drive distinct transcriptional landscapes and isoform diversity contributing to human-specific traits.

The uneven surfaces of copper indium gallium selenide (CIGS) solar cells pose challenges for depositing the upper layers in flexible perovskite/CIGS tandem solar cells. Ying et al. tackle this issue using an antisolvent and seeding strategy, resulting in a certified efficiency of 23.8%.

Targeted multielement substitution of a lead-free relaxor ferroelectric perovskite distorts the lattice structure and induces strong polar disorder, leading to high-polar-entropy ferroelectric oxides with a high electrocaloric effect and long lifetime.

A newly identified coronavirus isolated from farmed minks can use the receptor ACE2 to infect cells of different mammalian species, including human cells, which has implications for potential zoonotic spillover events.

Effects of snow cover dynamics, land use or land cover conversions and non-conversion regions on albedo variations during 2001–2020 are quantified and their induced radiative forcing estimated, highlighting the role of land surface dynamics in modulating global warming.

Stomata are key entry points for plant pathogens. Here, the authors engineer stomata-targeted nanoparticles to reduce bacterial colonization while preserving stomatal function, enabling a more precise strategy to enhance crop defence.

This study reveals the genetic basis of Benzylisoquinoline alkaloids (BIAs) biosynthesis in magnoliids, and further illustrates that preferentially retained ancient gene duplicates enabled BIA production in early-diverging eudicots and magnoliids.

The authors present an efficient hot-electron generation system facilitated by the spin-exchange Auger process in Mn2 + -doped CdS/ZnS quantum dots. These hot electrons can be used in a wide range of organic reactions, such as the Birch reduction and reductive cleavage of C-Cl, C-Br, C-I, C-O, C-C, and N-S bonds.