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The positive electrode/electrolyte interface is crucial for the performance of all-solid-state lithium batteries. Here, authors use a sintering technique to form a conformal interface between high-entropy disordered rock salt electrodes and garnet-type electrolytes to reduce interfacial resistance.

The authors present a 3.5-million-year-long pollen record from the Zoige Basin of the eastern Tibetan Plateau, 3,442 m above sea level. The ~5,000 pollen assemblages retrieved from the core reveal many ecosystem transitions during this time and, when correlated with climatic curves, indicate what effects future warming may have on regional vegetation.

Chen, Zhou, Xue et al. show that psychological stress leads to noradrenaline release and Alkbh5 downregulation, causing the transfer of extracellular vesicles containing m⁶A-modified RNAs to neurons to regulate innervation and pancreatic cancer development.

Honeybee behavioral plasticity provides a model to study how brain gene networks regulate behavior. Here, authors show stripe activation in Kenyon cells links gene regulatory networks to behavioral maturation via spatial-cellular coordination.

While Bell inequalities have been violated several times—mostly in photonic systems—their violations within particle physics experiments are less explored. Here, the BESIII Collaboration showcases Bell-violating nonlocal correlations between entangled hyperon pairs.

The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.

Heterogeneous single-atom catalysts (SACs) offer high atom utilization and well-defined active sites but face challenges in multi-stage cross-couplings due to limited coordination and reactivity. Here, the authors introduce SACs on reducible carriers, enabling adaptive coordination to bypass oxidative addition in cross-couplings.

The conversion of carbon dioxide to higher-value chemicals is an industrially important reaction. Here, the authors report a hybrid catalyst manganese oxide nanoparticle supported on mesoporous cobalt oxide, which catalyses the conversion of carbon dioxide to methanol at high yields.

Here, the authors perform a pan-genome-based genome-wide meta-analysis of six independent GWAS experiments in rice, demonstrating the potential of this approach to increase understanding of the genetic basis of, and genes underlying key rice traits.

Current brain-targeted delivery strategies using orthosteric sites of receptors is highly susceptible to cross-reactions limiting efficiency. Here, the authors report on the allosteric targeting of receptors to avoid this and demonstrate application in drug delivery across the blood brain barrier.

Most LiDARs have an intrinsic tradeoff between acquisition rate and non-ambiguity range. Researchers demonstrated a LiDAR called RRMFC based on an integrated lithium niobate frequency comb, leading to a 1.79 GHz acquisition rate and infinite non-ambiguity range.

The ectoenzyme CD73 is often elevated in tumour environments and targeting this protein is a tumour therapeutic target. Here the authors characterise a therapeutic anti-CD73 antibody cocktail which is more effective than either antibody alone and suggest a molecular mechanism of how this antibody cocktail functions.

Here, the authors employed 19 F NMR and Gaussian accelerated MD simulations to determine the conformational landscape of the adenosine-A2A receptor and mini-Gαsβγ complex, enabling determination of an intermediate structure of the complex with cryoEM.

Multi-omic analysis of the adult human prostate identifies spatially resolved cell populations with potential links to prostate carcinogenesis.

Hydrogen-doping driven metal to ferroelectric phase transition in a complex oxide NdNiO₃ is demonstrated. Transient negative differential capacitance and implementation of polarization decay into neural network for learning are then presented.

The underlying mechanisms for drug resistance in Acute Myeloid Leukemia (AML) are not completely understood. Here, the authors show that succinate accumulation, associated with succinate dehydrogenase deficiency, impairs the activity of the ubiquitin-conjugating enzyme UBC12 leading to tumor-promoting protein accumulation and drug resistance in AML.

Here a strategy is proposed to increase the temperature stability of polymer dielectrics by using mechanical bonding from cyclic polyethers to damp the local vibrations of polymer chains, thus inhibiting high-temperature charge transport and enabling a discharged energy density of 4.1 J cm⁻³ with 90% efficiency at 250 °C.

The electrocatalytic NO reduction reaction enables sustainable NH₃ synthesis and NO removal but faces challenges in achieving industrial-level efficiency and durability. Here the authors present an in situ-formed copper nanowire array monolithic electrode integrated into a pressurized electrolyzer for stable ammonia electrosynthesis at around 1000 mA cm^–2 for 100 h.

Water splitting using earth-abundant materials promises a low cost solution to the problem of large scale energy storage. Here, the authors fabricate a haematite and silicon-based high-efficiency water splitting device, which operates without the need for an externally applied bias.

Adding nanobodies into DNA computing has proven difficult due to there always on state. Here, the authors propose a spatial segregation-based molecular computing strategy to program nanobodies into DNA molecular computation and elucidate the kinetic mechanism of microenvironment-confined DNA molecular computation.

Lightweight, flexible and strong fibre actuators that respond to solvents and vapours are made by twisting together several well-aligned helical fibres of multiwalled carbon nanotubes.

Higher diurnal temperature range in humans correlates with the prevalence of sarcopenia. Here, the authors show that fluctuated temperature exposure accelerates muscle atrophy and dampens exercise performance via altering microbiota composition in aged mice.

Diagnosis of lung cancer from indeterminate pulmonary nodules remains challenging. Here, the authors develop a multi-omics signature to identify oncogenic nodules, and prevent unnecessary procedures.

Electrochemical alcohol oxidation offers a promising approach to produce valuable chemicals that can be paired with fuel-producing reactions. Here, authors utilize gold and cobalt oxyhydroxide nanomaterials to obtain industrially-relevant electrolyzer current densities for benzyl alcohol oxidation.

CIRP deficiency can significantly ameliorate multiple organ damage in AP by alleviating endothelial cell hyperpermeability and microcirculation disturbance. Targeting CIRP is a potential therapeutic strategy for AP-induced multiple organ damage.

Developing highly durable and active low-platinum electrocatalysts is crucial for advancing proton exchange membrane fuel cell technology. Here, the authors report PtFe on a single-atom Fe-N-C substrate to regulate the spin occupancy state of the Pt d-orbital for enhanced oxygen reduction reaction in proton exchange membrane fuel cell.

The controlled growth of large-area single-crystalline 2D semiconductors remains a significant challenge for their electronic applications. Here, the authors report a quasi-equilibrium growth method to synthesize inch-scale monolayer α-In₂Se₃ with high mobility and ferroelectric field-effect transistor performance.

Post-translational addition of O-linked N-acetylglucosamine (O-GlcNAc) to proteins is associated with stress responses in eukaryotes. Here, the authors identify a protein that acts as an O-GlcNAc transferase for modification of multiple proteins and regulates antioxidative stress responses in the bacterial pathogen Yersinia pestis.

The prognostic value of tumor infiltrating lymphocytes in gastric cancer remains controversial. Here the authors show a consistent association between higher density of intratumoral CXCR5+CD8+ T cells and longer overall survival in four different cohorts of patients with gastric cancer.

The authors developed a computational method, HEARTSVG, which accurately identifies spatially variable genes in large-scale datasets, enhancing our understanding of tissue organization and disease mechanisms.

Seawater direct electrolysis using renewable energy provides an appealing pathway to harness abundant oceanic hydrogen resources. Here, authors report a redox-mediated decoupled seawater direct electrolysis strategy to suppress the chlorine electro-oxidation side reaction.

The cellular and molecular mechanisms underlying major depressive disorder are unclear. Here, the authors report cell type- and cortical layer-specific gene expression changes and identify one microglia subpopulation associated with depressive-like behavior in female non-human primates.

Potassium-ion batteries are a promising alternative to lithium-ion batteries. Here, authors characterise the solid-state diffusivities and exchange current densities of leading negative and positive electrode materials, enabling full-cell modelling to identify the properties limiting rate capability.

Alterations in the tumour suppressor genes STK11 and/or KEAP1 can identify patients with advanced non-small-cell lung cancer who are likely to benefit from combinations of PD-(L)1 and CTLA4 immune checkpoint inhibitors added to chemotherapy.

Here authors use calorimetry to quantify chemical short-range order (CSRO) experimentally, in good agreement with atomistic simulations. Synchrotron in-situ tensile testing showed no effect of varied CSRO levels on mechanical properties.

Efficient delivery of extracellular vesicles to the injured spinal cord, with minimal damage, remains challenging. Here, the authors fabricate a minimally invasive microneedle device, which provides efficient and sustained extracellular vesicle delivery for spinal cord injury treatment.

The authors develop a metabolic engineering strategy for improving polyketide production of industrial interest and discovering new natural products in bacteria.

Metabolic dysfunction-associated steatohepatitis (MASH) poses challenges for targeted delivery and retention of therapeutic proteins due to excess extracellular matrix (ECM). To address this, the authors developed a “Fibrosis Overexpression and Retention (FORT) strategy” that can improve mRNA expression in the fibrotic region and extend the expressed protein in situ.

A cellular-nanoporation method produces large quantities of exosomes containing therapeutic mRNAs and targeting peptides that restore tumour-suppressor function in mice with orthotopically implanted phosphatase and tensin homologue (PTEN)-deficient brain gliomas.

Influenza virus uses metabotropic glutamate receptor 2 (mGluR2) as an endocytic receptor to enter cells through clathrin-mediated endocytosis.