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Dopaminergic dysfunction is a key of Alzheimer’s disease pathogenesis. Here, the authors developed a multifunctional neural interface that simultaneously monitors dopamine dynamics and neural activity while delivering 40 Hz stimulation to rescue cognitive deficits in APP/PS1 mice.

Sadhu et al. identify and functionally validate ferredoxin-1 (FDX1) as a determinant of cholesterol metabolism and cardiovascular risk in Asian populations.

Diverse methyl β-C−H functionalizations of ketones and esters are enabled by cationic Pd(II) complexes with MPANA ligands, offering access to spirocyclic and fused ring systems through enhanced catalyst–substrate affinity.

Current brain organoids protocols face significant challenges in achieving adequate neural maturation to effectively replicate the functionality of mature neural circuits. Here, authors present an approach by integrating astrocyte-secreted factors to facilitate maturation and functional fidelity of in vitro brain organoids and planar neural cultures.

Secondary arylalkylamines represent important building blocks for organic synthesis, and as such their straightforward synthesis from readily available chemicals remains a priority in organic chemistry. Here, the authors report a synthesis of arylalkylamines from nitroarenes and carbazates via paired electrolysis.

The symmetry and mechanism underlying unconventional charge orders in Kagome materials are under debate. Here, the authors uncover a longitudinal and helicity-dependent photocurrent in KV₃Sb₅ that indicates broken symmetries and intrinsic chirality.

Shrub encroachment into grasslands affects species biodiversity and ecosystem functioning, but its impact on herbaceous diseases and the role of climatic factors remain unclear. This study finds that shrubs reduce pathogen load in colder regions but may increase it in warmer regions, with temperature being the primary driver of these variations.

Here, the authors perform a pan-genome-based genome-wide meta-analysis of six independent GWAS experiments in rice, demonstrating the potential of this approach to increase understanding of the genetic basis of, and genes underlying key rice traits.

Here, the authors fabricate a metasurface with high brightness and large gamut structured colors by combining a silicon metasurface with a refractive index matching layer. The experimentally demonstrated gamut is 181.8% of sRGB, 135.6% of Adobe RGB, and 97.2% of Rec.2020.

A biodegradable electronic bandage that applies pulsed and d.c. electrostimulation can accelerate the healing of intestinal wounds in mice via transfection of cells and stimulation-induced secretion of healing factor from those cells.

Ferroelectric field-effect transistors based on molybdenum disulfide can be used to build an in-memory sparsity architecture in which index memory is moved next to individual synapses, creating a sparse neural network without external memory indexing.

LaAlO₃/KTaO₃ interfaces show novel orientation-dependent superconductivity. Here, the authors directly reveal the interfacial electronic structures and suggest that higher superconducting transition is related with stronger electron-phonon coupling.

This study demonstrates that the adaptor protein AP-3β recruits the 19S regulatory particle (RP) of the proteasome to stress granules (SGs) after heat stress and promotes SG disassembly through RP-associated deubiquitylation process.

The direct impacts of transposable element dynamics on polyploid regulation and developmental specificity remain unclear. Here, the authors show that a large proportion of enhancer-like elements (ELEs) are mainly originated from RLG_famc7.3 specifically expanded in subgenome A, producing active nascent transcripts and influencing wheat spike development.

A 43-year dataset of rodents in the Hu region of China reveals how urbanization-induced changes to land-use configuration affect rodent community composition, including benefitting striped field mice, the primary local hosts of the zoonotic pathogen Hantaan virus.

Using single-cell and multi-omics data of fetal blood, a high-resolution molecular map of dysregulated haematopoiesis in Down syndrome is provided.

The generation of cracks in polycrystalline Ni-rich layered lithium transition metal oxides presents numerous challenges for their use in batteries. Here, authors propose a gradiently distributed pores structure within the oxide secondary particles, reducing internal strain accumulation.

How subgenome-divergent and -convergent transcription is mediated and harmonized in hexaploid common wheat genome remains unclear. Here, via characterizing the cistrome maps, the authors reveal that transposon elements with transcription factor binding ability have the potential to make the contribution.

Superionic fluoride dielectrics with a low ion migration barrier are capable of excellent capacitive coupling and are highly compatible with scalable device manufacturing processes for integrated electronics.

The plant vacuole plays important roles in regulating growth and development. Now, the vacuole in Arabidopsis root cells is presented at nanometre resolution by 3D whole-cell tomography, suggesting a cellular mechanism for plant vacuole formation.

Doping approach is a conventional method to increase ZT values of thermoelectric materials. Here, authors propose a facile strategy to enhance thermoelectric performance by mixing boron particles into GeTe-based thermoelectric materials, leading to a ZT value of 2.45 at 613 K.

SEAMLESSM4T is a single machine translation tool that supports speech-to-speech translation, speech-to-text translation, text-to-speech translation, text-to-text translation and automatic speech recognition between up to 100 languages.

Predictive methods for gastric cancer to try and differentiate between potential treatment response are required. Here the authors use a multiplexed immunohistochemistry method to propose the proximity of tumour infiltrating immune cells as an indicator of likely therapeutic response.

Palladium-catalysed C(sp³)–H amination reactions of carboxylic acids are challenging due to N-coordination often outcompeting the carboxylic acid directing effect. Now, the development of chlorinated pyridine–pyridone ligands for palladium-catalysed methylene C(sp³)–H lactamization and cycloamination is reported, enabling the synthesis of lactams and cyclic amines.

Cu₂Se is of interest for thermoelectrics as it is environmentally sustainable and has a high figure of merit ZT; however, copper ion migration impacts device stability. Here a co-doping strategy that combines steric and electrostatic effects is shown to improve device stability as well as improving ZT to 3.

The intrinsic high-concentration Ge vacancies in GeTe-based thermoelectric materials hinder their performance maximization. Here, the authors find that defect structure engineering strategy is effective for performance enhancement.

Ultraviolet photoacoustic microscopy in reflection mode can be used to intraoperatively evaluate undecalcified and decalcified thick bone specimens without sectioning them.

The utilization of Mg₃(Sb,Bi)₂ in thermoelectric devices is hindered by its low performance near room temperature. Here, authors report thermoelectric performance enhancement of Mg₃(Sb,Bi)₂ within a wide temperature range by incorporating metallic inclusions at grain boundaries. (279 in total)

It was proposed that protein kinase M-ζ (PKM-ζ) is a key factor in long-term potentiation (LTP) and memory maintenance on the basis of the disruption of LTP and memory by inhibitors of PKM-ζ; however, here mice that do not express PKM-ζ are shown to have normal LTP and memory, thus casting doubts on a critical role for PKM-ζ in these processes.

The PI3K/AKT signalling pathway regulates cancer metabolism. Here, the authors show a reciprocal positive feedback crosstalk between the PI3K/AKT and pentose phosphate pathway which promotes tumourigenesis.

Integrating human mobility and activity data with ground-level measurements and air quality models, Shen et al. find that despite a reduction in outdoor PM_2.5 during the COVID-19 quarantine in China, overall population exposure to PM_2.5 increased.

Zero thermal expansion alloys have unique dimensional stability but suffer from inherent brittleness and compositional sensitivity. Here the authors present the one-step eutectic reaction approach to produce a dual-phase alloy with an axial zero expansion and promising mechanical properties.

How electron correlation interplays with topological states remains rarely explored. Here, the authors report flat band arising due to electron correlations in magnetic Weyl semimetal Co₃Sn₂S₂ from a combined optical-spectroscopy and simulation study.

A power generator exhibits enhanced output due to a dual-charge-carrier design. The voltage produced is constant yet competitive even under low relative humidity.