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Cao et al. report an A-site co-doping strategy by substituting Cs+ cation by alkali metals for perovskite quantum wires embedded in nanoporous alumina template, stabilising the crystal structure and enabling high-colour purity LEDs spanning from blue to green spectral region.

Here the authors show that viral infections facilitate accumulation of cellular iron by degradation of iron exporter ferroportin (FPN1), and that high intracellular iron suppresses type I IFN responses and autophagy by promoting TBK1 hydroxylation and STING carbonylation.

In-situ harvesting of wave energy can provide a continuous energy supply for oceanic unmanned equipment. Here, the authors develop a pendulum-based nanogenerator that efficiently converts disordered waves into electricity for self-powered, distributed marine monitoring networks.

Ethanol production from CO2 electroreduction is hindered by poor carbon–carbon coupling and competing ethylene formation. Here, the authors develop a ZnO1-x-shield copper catalyst that stabilizes Cu+ species and enables efficient and selective electrochemical ethanol synthesis.

Long-term observations show that a rising fraction of ammonium nitrate in PM_2.5 reduces aerosol acidity, suppressing the heterogeneous conversion from NO₂ to HONO. This weakens its contribution to the HONO source and atmospheric oxidation capacity.

Arousal-modulating neural circuitry remains enigmatic. Here, authors show that the pathway, glutamatergic ventral pallidal neuron→locus coeruleus noradrenergic neuron→the lateral hypothalamus, controls arousal in awake and anesthetized states.

Recently, a pipeline for the design of protein-binding proteins using only the structure of the target protein was reported. Here, the authors report that the incorporation of deep learning methods into the original pipeline increases experimental success rate by ten-fold.

Preliminary results from a phase 2a trial involving 71 patients suggest that a new agent, discovered and designed with artificial intelligence assistance, is safe and effective for the treatment of idiopathic pulmonary fibrosis.

Profiling nuclear N⁶-methyladenosine (m⁶A) modifications revealed enrichment of m⁶A on nuclear RNAs derived from chromosome pericentromeric γ satellite DNA II (GSATII), which regulates GSATII transcription and influences chromosome segregation during mitosis.

In a prespecified interim analysis of the randomized, double-blind phase 3 COMPASSION-15 trial, patients with advanced HER2-negative gastric/GEJ cancer treated with the anti-PD-L1/CTLA-4 bispecific Ab cadonilimab plus chemotherapy showed significantly improved overall survival compared with patients treated with placebo plus chemotherapy as first-line treatment.

Neural mechanisms underlying sex-dependent conditioned pain hypersensitivity are not fully understood. Here authors found that a neural circuit from the medial preoptic area to the ventrolateral periaqueductal gray mediates context-dependent pain hypersensitivity in male, but not female, mice, which requires activation of testosterone signaling.

Insulinomas develop from pancreatic β-cells and secrete insulin, but the underlying genetic defects are largely unknown. In this study, Cao et al. identify recurrent T372R mutations in the transcription factor YY1, and validate this hotspot mutation in 30% of insulinomas.

The genomic epidemiology of Acinetobacter baumannii, which is rising in virulence and multidrug resistance, was explored. This study examined bloodstream infection isolates from Chinese patients in 2011–2021, revealing increased genetic diversity and dominance of highly virulent ST208.

This study reveals the structural basis of collagen processing by the KOGG complex, revealing how it catalyzes lysine hydroxylation and dual-glycosylation, essential for collagen folding and stability, with implications for collagen-related diseases.

Reducing critical materials such as indium and silver is of high importance for photovoltaics. Yu et al. demonstrate a certified 25.94% efficiency silicon heterojunction solar cell replacing part of indium-based electrodes with undoped tin oxide and using copper for contacts.

Worldwide, the number of only-child families is increasing. This research examines how growing up without siblings affects adult brain structure, function and connectivity, cognition, personality and mental health.

Here they identify a selective PRC1.1 inhibitor, iBP, that treats bone loss by improving osteoblast function. iBP releases repression of Wnt/β-catenin signaling, enhancing bone formation and repair in aging, trauma, and disease models.

This study reveals the mechanisms connecting DNA methylation and totipotent gene expression in somatic cell reprogramming. SUVH-SDJ-AHL complex binds to CHH-hypermethylation regions and interacts with LEC2, establishing a feed forward loop to activate totipotency-regulating genes.

Sun et al. report human lifespan changes in the brain’s functional connectome in 33,250 individuals, which highlights critical growth milestones and distinct maturation patterns and offers a normative reference for development, aging and diseases.

Necroptosis in cancer cells remains incompletely understood. Here, the authors show that inhibition of FGFR2 could induce necroptosis via crosstalk between the NF2-Hippo-YAP and RIP1-MST1-MLKL pathways and shapes an immunosuppressive tumor microenvironment.

A quantum microsatellite, with a payload weighing only 23 kilograms, in combination with portable ground stations that weigh merely 100 kilograms, is capable of performing space-to-ground real-time quantum key distribution.

Hydrogels are of increasing interest in the materials community, but precise control of mechanochemistry is still challenging. Here, the authors report the use of a tensegrity architecture to prepare hydrogels with favourable properties.

An avian influenza H7N9 virus causes severe human disease, including acute and often lethal respiratory failure. Here, the authors report that plasma levels of angiotensin II, a regulatory peptide of the renin–angiotensin system, are associated with disease severity and fatal outcome in infected patients.

Single atom catalysts offer a promising approach for CO₂ electroreduction to CO, but achieving high efficiency remains challenging. Here, the authors report lanthanide single atom catalysts with the transition ability from bridge to linear adsorption that exhibit efficient CO production.

Socioeconomic status is multidimensional and can change over time. Xu, Lui, Ji et al. found dimension-specific, late-stage-specific and change-specific socioeconomic effects on brain, cognition, personality and emotion.

Fragility describes the sharpness of dynamical arrest of a melt at its glass transition, yet its structural origin remains elusive. Shi et al. show that fragility inversely correlates with the medium-range order structure characterized by a measurable parameter named the average medium-range distance.

Early detection and accurate diagnosis of focal liver lesions are crucial for effective treatment and prognosis. Here, the authors present a fully automated diagnostic system that leverages multi-phase CT scans and clinical features, for diagnosing liver lesions.

Under low-protein conditions, decrease of protein NUFIP1 is found to impair DNA damage response and induce necroptosis in the intestine, thereby contributing to intestinal inflammation in male mice with inflammatory bowel disease.

Collagen requires complicated modifications for proper assembly. Here, the authors show the structural basis of human collagen processing by the P3H1/CRTAP/PPIB complex, revealing a ‘face-to-face’ catalytic site configuration, collagen binding sites, and transition between trimer and hexamer states.

Closed pores govern sodium-ion storage performance of hard carbon negative electrodes. Here, authors link pore mouth size evolution of the closed pores to the solvation structure and propose design principles for optimizing both closed pores and intrinsic defects.

This work shows a strategy to engineer the orientation of covalent organic framework membranes to an axis-aligned configuration that enables record performance for osmotic energy harvesting.

Early and accurate clinical assessment of disease severity in COVID-19 patients is essential for planning the allocation of scarce hospital resources. An explainable machine learning tool trained on blood sample data from 485 patients from Wuhan selected three biomarkers for predicting mortality of individual patients with high accuracy.

Cement production is a source of CO₂. Analysis of carbonation, a process that sequesters CO₂ during the lifetime of cement, suggests that between 1930 and 2013, it has offset 43% of CO₂ emissions from cement production globally.

Lu and colleagues show that signaling through the lactate receptor HCAR1 in colorectal tumor cells promotes the recruitment of immunosuppressive CCR2⁺ PMN-MDSCs and that inhibition of HCAR1 by reserpine augments the CD8⁺ T cell-mediated antitumor immune response.

By constructing a graph-based grapevine pangenome reference (Grapepan v.1.0) and incorporating structural variations and phenotypic maps, the study investigates the genetic basis of agronomic traits, empowering grapevine genomic breeding.

Ancient DNA, stable isotopes and other archaeological methods establish that humans were living at extremely high elevation on the Tibetan Plateau 4,400 years ago, maintaining sedentary lifestyles that combined fishing, hunting and crop exchange.

Renal cell carcinoma consists of several subtypes, and recurrence is highly dependent on subtype. Here, the authors develop a multi-classifier using imaging, lncRNA and clinical data to predict recurrence in papillary renal cell carcinoma.

A ketogenic diet and the ketone body β-hydroxybutyrate are shown to confer resistance to malaria in mice by inducing metabolic reprogramming in Plasmodium parasites, suggesting a dietary strategy for malaria prevention.