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The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.

The authors propose a matrix plainification strategy to eliminate lattice vacancies in the Cu2Se matrix of the Cu2Se/SnSe composites, resulting in obvious improvement in carrier mobility and power factor, obtaining a high figure of merit of 3.3.

APOL9a/b proteins coat mouse intestinal bacteria with high specificity, and genetic abolition of ceramide-1-phosphate synthesis pathways in the symbiote Bacteroides thetaiotaomicron significantly decreases this binding of APOL9a/b to the bacterium.

Molecular interactions are of great importance in materials science. Here, the authors use the confinement effect and low-dose imaging to reveal the confined molecules and evaluate the strength of host-guest interactions in different material systems.

Light-emitting diodes with suppressed efficiency roll-off can be created by intercalating oxygen plasma into few-layer molybdenum disulfide and tungsten disulfide.

Fabricating semiconductor devices with dimensions below 10 nm presents significant challenges. Here, Liu et al. use controlled electron irradiation to remove atoms in an MoS₂ sheet, creating Mo₅S₄nanoribbons with a uniform width of 0.35 nm and a theoretical band gap of 0.77 eV.

Controlling Li nucleation and growth is crucial to avoid dendrite formation. Here, Li₂S(111)@Cu is used as Li metal electrode substrate, where a substrate-dependent Li nucleation process and a facet-dependent growth mode are identified, enabling dense Li deposition and improved battery performance.

A new deep learning-based global medium-range weather forecasting model outperforms existing machine learning models and the European Centre for Medium-Range Weather Forecasts model, producing accurate global weather forecasts beyond ten days.

Ym1, encoding a CC-NBS-LRR type resistance protein, confers defense to wheat yellow mosaic virus (WYMV) infection in roots. Ym1’s function in preventing viral invasion is dependent on its interaction with WYMV coat protein and followed by induction of cell death.

Septins are the key component of the cytoskeleton. Here, the authors show that Septin5 is assembled in microtubule-plasma membrane contact sites and mediates insulin secretion in pancreatic islet β-cells through cortical microtubule remodeling.

The immune response of immunotherapy in colorectal cancer remains low and new adjuvant targets are in demand. By in vivo CRISPR-Cas9 screening that targets membrane and secreted proteins genes, the authors identify that disrupting MBTPS1 in tumor cells upregulates STAT1-transcribed chemokines, promotes CXCR3⁺ CD8 T cells infiltration and potentiates anti-PD-1 therapy.

The design of easily synthesized high molecular weight giant molecular acceptors is urgently needed. Here, the authors report a branch-connected dendritic hexamer acceptor that exhibits enhanced charge transport ability, achieving device efficiency of 19.4% for binary organic solar cells.

A quantum microsatellite, with a payload weighing only 23 kilograms, in combination with portable ground stations that weigh merely 100 kilograms, is capable of performing space-to-ground real-time quantum key distribution.

Low-temperature ultraclean integration of large-area MoS₂ thin-film transistors with nitride micro-LEDs through a back end of line process enables the demonstration of displays with high resolution and uniformity.

Qu et al. report a self-assembled material with π-expanded conjugation to form hydrophilic ordered bilayer as hole selective layer for inverted perovskite solar cells. The enhanced interfacial charge extraction and transport enable certified efficiency of 26.39% and 25.21% for 7.15 mm² - and 99.12 mm² -devices, respectively.

There is great interest in molybdenum disulphide for electronic devices but the mechanism of charge transport remains elusive. Qiu et al. find that sulphur vacancies introduce localized donor states within the bandgap, enabling low-carrier-density transport via hopping.

While CDK4/6 inhibitors have become standard of care in patients with HR+/HER2- advanced breast cancer (ABC), selecting the optimal inhibitor could improve care further. Here, the authors report planned interim analysis of the BRIGHT-2 study, a randomised phase 3 trial comparing bireociclib (CDK4/6i) and fulvestrant (ET) against placebo and fulvestrant in female HR + /HER2- ABC patients.

A new type of carbon, long-range ordered porous carbon, is synthesized from carbon fullerenes at the gram scale and under ambient pressure.

Resolving the structures of MOFs is significant for understanding their structure-property relation. Here, authors apply a low-dose imaging technique to resolve the atomic structures of building units in MOF MIL-125. A low-symmetry structure of MIL-125 is discovered by directly imaging the rotated Ti-O nodes, different from the unrotated one predicted in previous works.

The development of catalysts for practical asymmetric hydrogenation of ketones remains an important goal of synthetic organic chemistry. Here, an anionic iridium catalyst with excellent activity is reported and used in a hundred-kilogram-scale reduction as part of a route to chiral nicotine.

The authors observe the signatures of quadrupolar excitons in a WSe₂-WS₂-WSe₂ trilayer moiré superlattice, originating from the hybridization of the WSe₂ valence moiré flatbands. They further use electrostatic gating to reveal a hybridized interlayer Mott insulator state, with holes shared between the two WSe₂ layers but laterally confined in moiré superlattices.

Fan, Shang, Song, Chen et al. identify the Integrator–PP2A complex (INTAC) as a key regulator of cancer cell sensitivity to BET inhibitors through directly interacting with the RACK7–KDM5 complex to orchestrate epigenetic silencing in a catalytic-independent manner.

Virtual models boost smart manufacturing by simulating decisions and optimization, from design to operations, explain Fei Tao and Qinglin Qi.

Heterobilayers of transition metal dichalcogenides host moiré superlattices that give rise to strong electron interactions. Here, the authors study the photoluminescence from interlayer excitons in a WS₂/WSe₂ heterobilayer to reveal the onset of various correlated insulating states.

Molecular electronics or spintronics relies on manipulating the electronic transport through microscopic molecule structures. Here the authors demonstrate the selective electron pathway in single-molecule device by magnetic field which enables a tunable anisotropic magnetoresistance up to 93%.

Hydrogen isotope exchange is essential for the synthesis of deuterium-labeled compounds but remains challenging under mild conditions. This study demonstrates the selective deuteration of alkylarenes at room temperature using atomically dispersed surface barium hydride.

Low-loss superconducting aluminium cables and on-chip impedance transformers can be used to link qubit modules and create superconducting quantum computing networks with high-fidelity intermodule state transfer.

Atomic diffusion is a powerful tool for the synthesis of heterostructures, even though controlled atomic diffusion is difficult to achieve. Here, the authors control solid-solid atomic diffusion between an Ag nanowire and a Te nanowire, producing 1D heterostructures by applying an electrical bias inside a TEM.

Topological materials hold great promise for dissipationless information transmission. Here, the authors create Chern insulator junctions between domains with different Chern numbers in MnBi₂Te₄ to realize the basic operation of a topological circuit.

The development of 3d-metal-catalyzed β-C–H bond activation via 4-membered metallacycles remains an elusive challenge. Here, the authors report a Ni-Al bimetal-catalyzed β-C(sp3)–H bond activation of formamides via 4-membered nickelacycles.

Exotic states emerge from the interplay between band topology and ferromagnetism, but it remains less known in canted-antiferromagnetic phase. Here, the authors realize a canted-antiferromagnetic Chern insulator in atomically-thin MnBi₂Te₄ with electrical control of chiral-edge state transport.

The selective CO₂ photoreduction in water mediated by earth-abundant photocatalysts remains highly challenging. Here the authors present the coordinative anchorage of molecular catalysts on a pyridine-armed covalent triazine framework for CO₂ photoreduction to CO in fully aqueous solutions.

The presence of magnetic fields in protostellar jets has been predicted theoretically, but its experimental confirmation has been elusive so far. Here, the authors report the detection of SiO line polarisation in the HH 211 protostellar jet, indicative of the onset of magnetic fields.

Understanding the electromagnetic responses at subwavelength scales is important for achieving tunability. Using a combination of the near-field and far-field spectroscopy, the authors demonstrate a heavy fermion metamaterial with tunable dual-band optical responses by selectively and separately modifying the 4f and 5d band electrons.

Ligand-protected metal nanoclusters provide an ideal platform for investigating the balance of stability and activity in photoredox catalysis. Here, the authors apply a photochemical reduction–oxidation cascade method to synthesize an Au₈Cu₆ nanocluster with a robust structure and active surface.

Transparent absorbers for electromagnetic interference shielding are sought in the terahertz frequency range. The authors demonstrate organohydrogel-elastomer composites based on permittivity gradients, with strong ionic conduction loss, showing high absorption in the 0.5–4.5 THz band.

Iron pnictide superconductors represent a suggestive alternative to cuprate superconductors for achieving high transition temperatures. Using in situ angle-resolved photoemission spectroscopy, the electronic properties of FeSe are examined as a function of film thickness, providing valuable insights into the mechanism driving the superconductivity in this material.