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Porous 2D materials hold great potential for applications in catalysis and electronics. Here, the authors design a novel inorganic framework in which POM clusters function as “electron buffers” to stabilize active sites and reduce the energy barrier for toluene oxidation, paving the way for programmable catalytic materials with tailored electronic properties.

Effective development of rechargeable lithium-based batteries requires fast-charging electrode materials. Here, the authors report entropy-increased LiMn₂O₄-based positive electrodes for fast-charging non-aqueous Li metal batteries.

ATLAS is a tool for circuit tracing, demonstrated here in rodents. It allows anterograde transsynaptic tracing, starting from genetically defined neurons.

Existing methods to analyse spatially-resolved transcriptomics (SRT) data often fail to accurately capture cell boundaries. The authors propose STP, a method that integrates subcellular SRT data with nuclei-stained images to partition individual cells. STP demonstrates effective cell partitioning when applied to SRT data from fly and mouse embryos.

Climate-driven warming affects the reproduction of oviparous ectotherms. Here, authors identify and characterize a VtgR-mediated heat protection mechanism for oocyte development in both mud crabs and zebrafish.

Endochondral ossification is hard to recapitulate with human cells. Here, the authors generated SOX9+ sclerotomal progenitors from hPSCs, modeling key developmental stages of bone development and growth plate-like structures.

Existing isokinetic training devices are often heavy, bulky, and energy-consuming, which limits the rehabilitation opportunities only at designated hospitals. Here, the authors show a highly integrated and power-free knee rehabilitation robot that can provide home-based isokinetic training

Haoyang Li, Quan Lu, Zhong Wang, and colleagues present a cost-effective and fast 3D random-access confocal microscopy. They demonstrate its performance of fluorescent particles and live Hela cells.

Currently, there is limited understanding of the molecular subtypes of fumarate hydratase (FH)-deficient renal cell carcinoma (RCC). Here, the authors employ integrated genomics and transcriptomics to develop a CpG site-specific methylation signature for the identification of FH-deficient RCC, and to identify three distinct molecular subtypes for this rare but highly lethal kidney cancer.

The influence of pregnancy on Long COVID is not well understood. Here, the authors use electronic health record data from the United States to compare the incidence of Long COVID in females after infection in pregnancy with matched non-pregnant females of reproductive age.

The in situ growth of methylammonium lead triiodide crystals in γ-butyrolactone is investigated. A cooler interfacial layer that serves as a protective layer to preserve the crystal facet orientation is observed.

All-solid-state lithium–sulfur batteries have been recognized for their high energy density and safety. This Perspective explores sulfur redox in the solid state, emphasizing the critical roles of electrochemical kinetics, thermodynamics, mass transport and advanced techniques such as cryogenic electron microscopy to help bridge gaps in current understanding.

High permselectivity of nanofluidics remains a challenge in osmotic energy conversion. Here, authors construct two dimensional nanofluidics with Turing-type nanochannels, which provide extrinsic pathways to improve both ion selectivity and flux, thereby achieving efficient osmotic energy harvesting.

The reaction of a conductive ferroelectric matter to external electric field remains largely unknown. Here, the authors reveal the relationship between the electrically-driven crystalline ___domain transition along the multiple-polar directions and the resistance change.

Spatial omics technologies require alignment and stitching of slices for a 3D molecular profile. Here, the authors present SANTO, a coarse-to-fine method that rapidly determines spatial positions and overlap regions, then refines them, enabling integration across platforms and modalities.

The authors show that ELL3 maintains chromosomal ploidy by promoting spindle assembly and driving chromosome movement in oocytes. Deficiency of ELL3 results in oocyte aneuploidy and may lead to early miscarriage.

Revoking personal private data is one of the basic human rights. Here, the authors show AFS, a unified method to revoke patients’ private data from pre-trained deep learning models.

Polymer dielectric capacitors are important for energy storage, although they often suffer from low energy density, especially at high temperatures, and challenges in mass production. This study reports roll-to-roll fabricated composites enriched with subnanosheet fillers, showcasing enhanced performance even at elevated temperatures.

This study comprehensively benchmarks 18 state-of-the-art methods for cellular deconvolution of spatial transcriptomics and provide decision-tree-style guidelines and recommendations for method selection.

The stability of perovskite photovoltaics under reverse bias is limited and thus an issue for real-world applications. Nengxu Li and colleagues report the underlying degradation mechanism at the cathode side and a multilayer barrier to minimize it.

Nme2Cas9 has been well established as a genome editing platform. Here the authors engineer Nme2Cas9 to further increase the activity and targeting scope of compact Nme2Cas9 base editors and validate ___domain-inlaid Nme2-ABEs for single-AAV delivery in vivo.

Crystalline silica particle exposure in the airways can lead to lung silicosis and progressive fibrosis. Here the authors use mouse silicosis models to show mechanics activated fibroblasts promote conversion of ILC2 to ILC1-like cells pulmonary fibrosis and that this is associated with a Notch3-IL-18 signalling pathway.

A library of clusters based on anisotropic polyoxometalate clusters is synthesized. Different phases of superstructures are prepared by tuning interactions between and inside the polyoxometalate building blocks, which adds to our understanding of structure–property relationships at sub-nanometre scale.

Polarization reversal dynamics in sliding ferroelectrics is important for the application in slidetronics. Here, the authors observe the interlayer directional sliding induced polarization switching with simultaneous hysteresis response in γ-InSe:Y.

Polymer materials suffer mechano-oxidative deterioration or degradation in the presence of molecular oxygen and mechanical forces. Here the authors demonstrate a synthetic approach in which molecular oxygen and mechanical energy synergistically initiate polymerization and affords robustness in polymeric materials.

The efficiency of perovskite solar cells decreases over time, yet the underlying mechanisms are unclear. Ni et al. observe charged iodide interstitial defects within the device layers and how they contribute to the efficiency degradation when the cell is operated under illumination or reverse bias.

The plasma membrane Na⁺/H⁺ exchanger SOS1 is crucial for plant salt tolerance. Here the authors report the structure of SOS1 from Arabidopsis thaliana in two conformations, which provide structural and functional insight into SOS1 activity regulation.

The authors summarize the data produced by phase III of the Encyclopedia of DNA Elements (ENCODE) project, a resource for better understanding of the human and mouse genomes.

Nested structures are common throughout nature and art, yet remain challenging synthetic targets in supramolecular chemistry. Here, the authors design multitopic terpyridine ligands that coordinate into nested concentric hexagons, and show that these discrete supramolecules display potent antimicrobial activity.

Defect density reduction is pertinent for halide perovskite solar cells but a universal strategy has not been exploited. Here Chen et al. show that by fine tuning the alkaline environment in precursor solution, they can greatly suppress defects density and obtain high certified efficiency of 20.87%.

Respiratory complications after a COVID infection are a growing concern, but follow-up chest CT scans of COVID-19 survivors hardly present any recognizable lesions. A deep learning-based method was developed that calculates a scan-specific optimal window and removes irrelevant tissues such as airways and blood vessels from images with segmentation models, so that subvisual abnormalities in lung scans become visible.

Brain-inspired computing demands high-performance synapses. Here, the authors report a subnanosecond ferroelectric tunnel junction with 256 conductance states, 10⁹ endurance, and 5.3 fJ/bit energy consumption, satisfactory to build synaptic devices.

CO₂ methanation offers a route to synthetic methane production but typically requires high temperatures to achieve sufficient rates. This study presents light-driven CO₂ methanation on an Au/Ce_0.95Ru_0.05O₂ solid-solution catalyst with high CH₄ production rate and selectivity benefiting from synergistic photochemical and photothermal effects.

Room-temperature phosphorescence has attracted attention for bioimaging, but quenching in aqueous systems is an issue. Here, the authors report on the synthesis of a water soluble organic phosphorescent polymer and demonstrate application is cancer cell targeting and imaging.

CO₂ electroreduction to multi-carbon products in acids remains challenging due to the low efficiency and poor stability of C–C coupling. Here, the authors show that asymmetric CO binding at confined nanointerfaces enhances multi-carbon production, improves CO₂ utilization, and limits H₂ evolution.

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Stable electrochemical reduction to formate is still challenging. Here, the authors demonstrate a redox-modulation and active-site stabilization strategy for CO₂ to formate conversion over 100 days of continuous operation at 100 mA/cm² with a cathodic energy efficiency of 70%.

“k” is the electromechanical coupling factor, and determines the efficiency of conversion between electrical and mechanical energy or vice-versa in piezoelectric materials. Here, Yan et al. present an optimization strategy for “k” via texturing and covalency tuning that results in “k” values comparable to that of single crystals.