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Chen at al. show that CHD1 loss in SPOP-mutated prostate tumors confers castration resistance by increasing SREBP2-mediated cholesterol synthesis and subsequent androgen supply, an effect counteracted by combined androgen and cholesterol inhibition.

Tu, Qian et al. identify BAZ2B as an epigenetic regulator of hepatocyte senescence, linking liver aging to metabolic dysfunction-associated steatohepatitis through PPARα and lipid metabolism.

Although germanium shares similar chemical properties with silicon, synthesizing chiral germanium centers has proven significantly more challenging. Here, the authors use deborylative alkylation of germanium chlorides and copper-catalyzed diol desymmetrization to transform simple germanium tetrachloride into a chiral germanium center in four steps.

ctDNA is a promising method to monitor tumor burden in triple negative breast cancer. Here, the authors show that ctDNA detection correlated with prognosis after neoadjuvant chemotherapy but not at baseline.

Impaired Aβ clearance in late-onset Alzheimer’s disease (AD) affects progression. Here, the authors show that CD14 + CD16+ monocytes carry Aβ in peripheral circulation and CSF in AD, suggesting a role in Aβ clearance.

High-throughput immunoassay is crucial for scientific and clinical applications. Here, the authors introduce a multiplex immunoassay platform engineered by modifying a pipette tip with a self-assembled barcoded protein array. It outperforms the gold standard in sensitivity, speed, and sample volume.

A meta-transcriptomic analysis of the viromes of 2,438 mosquitoes of 81 species from across China identifies geographic hotspots of mosquito virus diversity, links between mosquito virome composition and host phylogeny, and a suggestion of long-distance mosquito dispersal.

A wax-aided immersion methodology is developed to yield graphene rolls with tunable chiral angles; these graphene rolls exhibit promising chiral electronic properties beyond those of other carbon allotropes.

Understanding the electrical double layer at solid-liquid interfaces is crucial for various technologies. Here, the authors present an optical method for direct visualization and quantification of the zeta potential at 2D material interfaces.

Parhizkar et al. show that lemborexant, an orexin receptor antagonist, protects against neurodegeneration in male tau transgenic mice by preventing tau protein build-up and inflammation, highlighting its potential for preventing neurodegeneration.

Lithium metal is an ideal anode material for rechargeable batteries but suffer from the growth of lithium dendrites and low Coulombic efficiency. Here the authors show that nanodiamonds serve as an electrolyte additive to co-deposit with lithium metal and suppress the formation of dendrites.

Waste lithium-ion batteries and low-density polyethylene plastics present environmental issues. Herein, the authors demonstrate a synergistic pyrolysis approach for efficient and selective lithium extraction and upgrading of transition metal-carbon composites.

Designing efficient redox mediators for solar-to-fuel conversion is a challenge, requiring multi-electron transfer, suitable redox potential, and stable pH buffering. Here, the authors report polyoxometalate-based mediators with defect engineering, enabling reliable solar-to-fuel conversion.

Flavin-dependent halogenases (FDHs) in nature produce organic halides under benign conditions, yet their practical application remains elusive and difficult to scale up. Inspired by FDHs, here the authors develop a biomimetic aerobic oxidative halogenation strategy that uses oxygen from the air to oxidize non-toxic halide salts.

An optimized transport of anions and cations is essential for the development of practical alkali metal batteries. Here, the authors report the use of Ti_0.87O₂ nanosheets as coating material of polypropylene separators for Li-S, Li-Se and Na-Se cells.

Double-stranded RNA (dsRNA) is key in immunity and cellular regulation. Here, using the PISA workflow, the authors find 218 proteins with altered solubility upon dsRNA binding. ZNF385A knockout activates interferon-β transcription and increases endogenous dsRNA levels, enhancing the bioactivity of 5-Aza-2’-deoxycytidine and NK cell-mediated cytotoxicity.

Local structure control is challenging in high entropy alloy (HEA) catalysts. Here, the authors report finely tailoring the local clustering in HEA catalysts through rational composition design and sequential pulse annealing, achieving enhanced activity and stability for ethanol electrooxidation.

The authors demonstrate the role and mechanism of triacylglycerol (TAG) cycling in polyunsaturated fatty acid biosynthesis and develop a strategy of decoupling the TAG biosynthesis and degradation to improve related biochemical synthesis.

The parasitic absorption caused by nonradiative damping of plasmonic effects limits the light utilization efficiency of optoelectronics. Here, authors employ green fluorophore and nickel oxide to recycle plasmon energy, achieving maximum device efficiency of 19.51% for flexible organic solar cells.

Microsatellite-instability-high gastric cancers typically respond to immune checkpoint inhibitors, but only a small proportion of patients in the microsatellite-stable group responds. Here authors stratify these patients via a semi-supervised learning approach using multi-omics input data and functionally validate T-bet+ CD8 + T cells as crucial factor in the immunotherapy response.

This study highlights the role Polar regions as a limiting factor in global sustainability due to teleconnection effects, and then propose a SDG target, key indicators, and emphasize Indigenous inclusion and global action.

Poor rate capability and low cycle stability are common problems in lithium-oxygen batteries. Xuet al.present a free-standing palladium-modified carbon-based cathode with a tailored porous honeycomb-like structure, which is capable of high-rate and long-term battery operation.

Materials for the selective transport of K⁺ have application in a variety of fields including water desalination and separation processes. Here the authors report charged porous subnanometer cages that are inspired in biological KcsA channels; high K⁺ transport rates and high K⁺/Li⁺ and K⁺/Na⁺ selectivity ratios are obtained, showing great potential in advanced sieving processes and efficient water treatments.

Lai et al. present a spatially resolved atlas of human atherosclerotic plaques, revealing cellular heterogeneity and identifying lymphoid structures and their potential functions and implications.

Catalysis is a crucial strategy for improving the performance of sulfur cathodes in Li–S batteries, yet few strategies have been established to design effective catalysts. Here, by uncovering a volcano-shaped trend between polysulfide adsorption and catalytic rate in transition-metal-doped ZnS, a highly efficient ternary sulfide is developed.

Solid–electrolyte interphase is crucial for stabilizing lithium metal anodes for rechargeable batteries. A molecular-level design using a reactive polymer composite is now shown to effectively construct a stable SEI layer and suppress electrolyte consumption upon cycling.

The flammability and toxicity of the currently used electrolytes are the concerns that must be addressed. Here the authors show a non-fluorinated and non-toxic ionomeric aqueous gel electrolyte called water-in-ionomer that allows an enlargement of electrochemical stability window and design of environmentally friendly battery cell chemistries.

Lithium cobalt oxides are used as a cathode material in batteries for mobile devices, but their high theoretical capacity has not yet been realized. Here, the authors present a doping method to enhance diffusion of Li ions as well as to stabilize structures during cycling, leading to impressive electrochemical performance.

Solution treatment and quenching can strengthen magnesium-lithium-aluminium alloys, but this strength decreases with ageing. Here, the authors show this is due to semi-coherent nanoparticle precipitation followed by coarsening, and control the lattice mismatch to stabilise the microstructure.

Coacervate dynamics are studied to aid in understanding of phase separation cells, but obtaining sufficient stability can be challenging. Here, the authors report the development of multi-component coacervates that self-organise by protein mediated photopolymerisation, and are stable for over 300 days.

The high cost and low efficiency of current deuteration methods hinder scalable deuteration of organic compounds. Here, the authors report an electrolyser using Pdδ + /NC cathode achieving the deuteration of aldehydes, ketones, imines, and alkenes under solvent-free conditions using pure D2O.

Many thrombolytic agents depend on plasminogen, leading to D-dimer accumulation. Here, Tang et al. report a plasminogen-independent thrombolytic enzyme that degrades blood clots and D-dimer without plasminogen.

Here, the authors performed plasma proteomics and metabolomics analysis and identify the vinculin (VCL) pathway as a key mediator of lung exudation in SARS-CoV-2 infections, particularly associated with Omicron infection. In a mouse model of infection inhibition of VCL leads to reduced lung pathology.

Aberrant activation of autoreactive T cells is a hallmark of autoimmune diseases. Here, by analysing CD4 T cells from patients with polymyositis and mice with experimental autoimmune myositis, the authors show that TIGIT limits the differentiation of inflammatory Th1 and Th17 cells via a metabolic-epigenetic mechanism, which involves the inhibition of CD28-mediated PI3K/AKT/mTOR costimulatory signaling.