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Azoxy products have rarely been synthesized using enzyme catalysts. Herein, the authors report that fungal unspecific peroxygenases are promising catalysts for synthesizing azoxy products from simple aniline starting materials.

Electrocardiogram is crucial for cardiovascular disease prevention, diagnosis, and prognosis. Here, the authors present a motion-unrestricted dynamic electrocardiogram system utilizing skin-conformal, imperceptible electronics for long-term, comfortable, and accurate 12-lead monitoring.

China operates a national surveillance program for acute respiratory infections and sampled over 200,000 patients between 2009–2019. Here, the authors present results from this program and describe patterns by age, pathogen type, presence of pneumonia, and season.

A two-phase assembly approach is developed to synthesize single-unit-cell-thick perovskite chains within single-walled carbon nanotubes. A direct X-ray detector constructed with the confined perovskite chains exhibits outstanding performance and ultrahigh stability under harsh conditions.

Methods for catalytically constructing of N–N axially chiral scaffolds have garnered significant attention. Here, the authors report a highly diastereoselective and enantioselective organocatalyzed [4 + 1] annulation method for synthesizing diverse valuable isoindolinones that possessing N–N axial and central chiralities.

A compositionally complex (high-entropy) doping strategy is proposed to fabricate zero-strain high-Ni and Co-free layered cathodes with superior structural and mechanical stabilities and long cycle life.

The compact Cas12f enzyme exhibits obvious delivery advantage for gene editing, but its activity remains suboptimal. Here, the authors have designed and optimized circular guide RNA (cgRNA) for Cas12f, which significantly improves the efficiency of gene activation and adenine base editing.

COVID-19-related non-pharmaceutical interventions impacted the circulation of other pathogens. Here, the authors compile a global viral activity dataset and compare the timing of resurgence of seven common respiratory viruses following the relaxation of interventions across different geographical regions.

Here, Xin Pan and colleagues found that activation of thyroid hormone receptor-β is necessary for alveolar epithelial cell differentiation during lung repair and regeneration, and confirmed a specific agonist and molecular targets for fibrosis therapy.

Achieving sustainability in wireless communications is crucial yet poses significant challenges. To address this, the authors propose and demonstrate a solar-powered programmable metasurface enabling hybrid light-to-microwave wireless communications.

The reversibility of lithium metal batteries is strongly influenced by the chemistry of the solid electrode interphase. Here the authors report a salt-philic and solvent-phobic interfacial design that leads to the formation of a robust interphase, considerably improving the cycle life of batteries.

An implantable ultrasound-induced wireless electrical stimulator and a machine learning-based pain classifier can generate programmable, closed-loop based self-adaptive electrical stimulation to the spinal cord to manage chronic pain.

Asymmetric Büchner reactions are an effective methodology to bring about synthetic complexity from the common benzene motif, but effective, general catalytic methods are scarce. Here, the authors present divergent asymmetric arene dearomatization from ynamides using copper catalysis, wherein the catalytic cycle proceeds via a putative vinyl cation intermediate.

A quantum microsatellite, with a payload weighing only 23 kilograms, in combination with portable ground stations that weigh merely 100 kilograms, is capable of performing space-to-ground real-time quantum key distribution.

Oxidative stress contributes significantly to postmenopausal osteoporosis by impairing osteoblast function, but its precise mechanisms remain unclear. Here, the authors show that estrogen deficiency reduces GPX4 expression, leading to phospholipid peroxidation that impairs osteoblastogenesis, while GPX4 activators including 6- and 8-Gingerols can mitigate these effects.

The history of halogen-containing solid electrolytes is presented, and the advantages of halogen-chemistry for solid electrolytes related to crystal structures, migration pathways and ion transport mechanisms are summarized. Finally, the main challenges and future developments of halogen-containing solid electrolytes are discussed.

Study reveals coeval rapid uplift and normal faulting along the Central Anatolian Plateau’s southern margin. U-Th dating of fault-related calcites deciphers active deformation above the Cyprus Subduction, linking deep mantle and surface processes.

The authors reveal nearly two-order magnitude of decoupling of the mean free path of the dominant electrons to that of phonons in Bi-Sb alloy, achieving an atomically homogeneous, coarse-grained sample through ultrafast quenching, enabling thermoelectric cooling down to the liquid nitrogen regime.

Cells undergoing ferroptosis secrete Galectin-13, which binds to CD44 and inhibits the plasma membrane localization of SLC7A11 in neighboring cells, thereby accelerating neighboring cell death and promoting ferroptosis propagation.

Wang et al. profile mitochondrial RNA across 47 human tissues from 838 individuals, observing that mitochondria keep two different aging clocks: proliferative tissues accumulate many random mutations, whereas nondividing tissues progressively acquire recurrent hotspot mutations.

The authors demonstrate a chemopiezoelectric effect in which the displacive migration of oxygen vacancies driven by an electric field induces a large strain in the surface layer of thin (K,Na)NbO₃ ceramics. They achieve an electrostrain of 1.9% under a field of −3 kV mm⁻¹, with thermal stability up to 200 °C.

Diarrhoea is a major cause of morbidity and mortality in China. Here, the authors present results from a large sentinel surveillance scheme from 217 hospitals in all 31 provinces in mainland China, including ~150,000 patients with acute diarrhoea and covering years 2009-2018.

Malignant pleural effusion is a challenge for cancer therapy. Here, the authors report on a piezoelectric nano-system that inhibits tumor growth in the thoracic cavity by piezo-generated reactive oxygen species using the intrapleural pressure, triggering immunogenic cell death, to treat malignant pleural effusion.

Atomic structure of alkali metal is difficult to be revealed at room temperature because of the chemical reactivity and irradiation sensitivity. Here the authors show that electron beam-induced in situ growth of alkali metals enables the investigation of atomic structure and growth kinetics at high spatiotemporal resolution.

MGAT1 is a glycosyltransferase critical for the synthesis and maturation of complex N-glycans. Here, the authors show that MGAT1 modulation of CD73 glycosylation and function regulates tumor immune response in triple-negative breast cancer.

This research highlights the role of a KNOX1 transcription factor in stalling receptacle growth in cucumber, leading to bisexual flowers with superior ovaries like those in tomatoes. These insights enhance our understanding of ovary formation and sex in cucurbits.

POMC and AgRP neurons in hypothalamus were widely known to regulate energy balance. Here, authors show that ARC^CRABP1 neurons are identified as a new player influencing appetite and metabolism.

Chromatin topology can impact gene regulation. Here, Wu et al. show that evolutionary changes in chromatin structure, particularly CTCF loops, can drive distinct transcriptional landscapes and isoform diversity contributing to human-specific traits.

Catalyst screening is an important process but it’s usually time-consuming and labor intensive. Here the authors report the prediction of oxygen vacancy for perovskites using machine learning techniques to develop suitable oxygen electrocatalysts for solid oxide fuel cells at reduced temperatures.

Limited whole genome sequencing (WGS) of Asian populations results in a lack of representative reference panels, hindering imputation of Asian ancestry-specific genetic variants. Here the authors use WGS data from 11,067 individuals across 17 Asian countries to create a new reference panel which shows improved imputation accuracy for South Asian populations.

Li-O₂ batteries are promising candidates for the next generation of rechargeable batteries, but the side reactions and poor cycling stability limit their applications. Here, the authors show a versatile ionic liquid with functional groups that can address both issues for cells operated in oxygen and air.

Precise control of water oxidation activity calls for the mastery of surface reconstruction of electrocatalysts. Here, the authors identify the structural origin of surface reconstruction on spinel oxides and report a criterion to evaluate the reconstruction degree, which enable the design of spinel pre-catalyst with controlled reconstruction ability.

The role of KLF10 in exercise-mediated anti-obesity effects is not clear. Here, the authors show that exercise-induced adipose KLF10 interacts with FOXO1 and recruits KDM4A to transactivate lipolytic genes, which defends against obesity in male mice.

A high-resolution terrain dataset was developed for the CE-6 landing site, revealing that its exposure age lies between CE-4 and CE-5 sites, with diverse material sources and covered by ejecta from a nearby 51-meter crater.

A plant kinase mediates symbiotic signalling and suppress host immunity to enable legume–rhizobium symbiosis.

Propane dehydrogenation is an important reaction for the production of propylene, although effective catalysts are generally constructed from precious metals. Here, the authors report a high-performing earth-abundant alternative system for this reaction based on a particular form of cobalt on siliceous zeolites.