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This study utilizes Stereo-seq to comprehensively map the geospatial architecture of breast cancer, revealing venular niches that promote immune infiltration and better clinical outcomes, offering new insights into tumor microenvironment regulation.

Photocatalytic water splitting is an attractive route to hydrogen production, but safely isolating hydrogen and oxygen products remains a challenge. Here, the authors propose a carbon nitride/grapheme (GR)-based sandwich structure, providing safe and effective photocatalytic hydrogen generation and capsule storage.

Here a strategy is proposed to increase the temperature stability of polymer dielectrics by using mechanical bonding from cyclic polyethers to damp the local vibrations of polymer chains, thus inhibiting high-temperature charge transport and enabling a discharged energy density of 4.1 J cm⁻³ with 90% efficiency at 250 °C.

Analysis of interactions between the wheels of the Zhurong rover and the terrain along the rover’s traverse reveals soils with high bearing strength and cohesion.

Newly evolved Xanthomonas citri pv. malvacearum isolates triggers recent bacterial blight outbreaks in cotton. Here, the authors show that a recently evolved TALE, Tal7b, activates host susceptibility genes GhSWEET14a and GhSWEET14b rather than GhSWEET10 to confer pathogenicity in these new isolates.

Nautilus, the sole surviving externally shelled cephalopod from the Palaeozoic, holds an important phylogenetic position to understand the evolution of cephalopods. A complete genome of Nautilus pompilius sheds light on the evolution of the pinhole eye and biomineralization.

There is a low efficiency of A-to-G base conversion in at specific positions using base editors. Here the authors fuse ABE8e with the Rad51 DNA-binding ___domain to generate a hyperactive ABE allowing improved A-to-G editing efficiency at the region proximal to the PAM and improved simultaneous A/C conversion efficiency.

Synthesizing precise conjugated nanostructures on a surface requires fine control over the covalent reaction pathways. Here, the authors show that reversible coordinative bonds can be used to template on-surface C-C coupling reactions, guiding the formation of porous organic nanoribbons.

NKp46 recognizes externalized calreticulin, which translocates from the ER to the cell membrane during ER stress, indicating a danger-associated molecular pattern that eliminates ER-stressed cells.

Controlled delivery of small molecule therapeutics is challenging. Here the authors report a simple and effective aptamer-based depot system where the formation of aptamer/drug complexes leads to sustained release, and using this approach demonstrate improved in vivo delivery of channel blockers.

Pathologic α-synuclein spreads from cell-to-cell through binding to the lymphocyteactivation gene 3 (Lag3). Here, the authors demonstrate that the amyloid β precursor-like protein 1 (Aplp1) interacts with Lag3 and facilitates the binding, internalization, transmission, and toxicity of pathologic α-synuclein.

Gasdermin D Cys191 is S-palmitoylated, and palmitoylation is required for pore formation.

Non-alcoholic fatty liver disease affects 25% of people worldwide. Here the authors report that spliceosome component Usp39 deletion in mice leads to spontaneous steatosis and impaired autophagy through the regulation of alternative splicing.

The development of liposome-based drug delivery systems has been hindered by the systemic toxicity and limited duration of effect due to insufficient drug loading and leakage of payload. Here the authors address these issues by designing aromatized liposomes that feature increased drug loading and slowed release compared to conventional liposomes.

Chemotherapy priming sensitizes triple-negative breast cancers to immune checkpoint blockade. However, immune suppressive myeloid cells may impede its optimal effect. Here authors characterise the immune suppressive myeloid cells via single-cell analyses of immune cells from low dose chemotherapy treated breast tumours and identify STAT1 signalling as a regulator for immune suppressive state.

Oxidative stress plays a crucial role in the pathogenesis of hepatic encephalopathy (HE). Here, authors show that the chemogenetic inhibition of GAD2 population in the SNr region, or the targeted overexpression of mitochondrial UCP2 in such population, or systemic application of a mitochondrial-targeting antioxidant drug Mito-Q could effectively ameliorate HE.

New cave records from monsoon regions improve the Greenland ice core chronological framework around the Heinrich Stadial 2 by an order of magnitude, suggesting a more active role of low-latitude hydroclimate in millennial-scale climate oscillations.

A direct search for effective electromagnetic interactions between dark matter and xenon nuclei that produce a recoil of the latter is carried out and the first constraint on charge radius of dark matter is derived.

Epigenetic inhibitors that promote antigen presentation and potentiate T-cell-mediated cytotoxicity can be identified by a high-throughput screen of cytotoxic T-cell activity in breast tumour organoids.

Nitrogen-doped lutetium hydrides LuH_2±xN_y synthesized using a high-pressure and high-temperature synthesis technique did not show near-ambient superconductivity at pressures below 40.1 GPa.

Achieving bright and efficient blue emission in metal halide perovskite light-emitting diodes has proven to be challenging. Here, the authors demonstrate high EQE and spectrally stable blue light-emitting diodes based on mixed halide perovskites, with emission from 490 to 451 nm by using a vapour-assisted crystallization technique.

Altered expression of splicing factors can contribute to tumour progression. Here the authors show that splicing factor BUD31 enhances ovarian cancer progression by promoting exon inclusion in the anti-apoptotic BCL2 family member, BCL2L12.

In response to microbial ligands, IRF5 promotes pro-inflammatory M1 macrophage activation and production of nitrous oxide. Here the authors show that nitrous oxide modifies IRF5 tyrosine residues as a negative feedback, limiting the inflammatory response and protecting from endotoxin shock.

The presence of flat bands near the Fermi energy may lead to an increase in electron correlations and result in unconventional states. Here, non-Fermi liquid behavior and anomalous superconductivity, with a nonmonotonic two-dome-like doping dependence, are observed in Sc₂Ir_4-xSi_x and attributed to spin-orbit-coupling driven flat bands.

Superconductivity was recently observed in Nd_0.8Sr_0.2NiO₂ films. Here, superconductivity is found to be absent in bulk polycrystalline samples of Sr-doped NdNiO₂, raising questions regarding the origin of superconductivity in this material.