Search

A reinforcement learning-based virtual reality system, implementing a series of sport sessions with coaching, was as effective as standard physical activity in reducing fat mass in adolescents, with positive effects on cognition.

R9AP is a key receptor for entry of Epstein–Barr virus into human epithelial and B cells, and interacts directly with the viral glycoprotein gH/gL complex to mediate virus–host membrane fusion.

Cao et al. report an A-site co-doping strategy by substituting Cs+ cation by alkali metals for perovskite quantum wires embedded in nanoporous alumina template, stabilising the crystal structure and enabling high-colour purity LEDs spanning from blue to green spectral region.

NatD is an acetyltransferase responsible for N-α-terminal acetylation of the histone H4 and H2A and has been linked to cell growth. Here the authors show that NatD-mediated acetylation of histone H4 serine 1 competes with the phosphorylation by CK2α at the same residue thus leading to the upregulation of Slug and tumor progression.

The uneven surfaces of copper indium gallium selenide (CIGS) solar cells pose challenges for depositing the upper layers in flexible perovskite/CIGS tandem solar cells. Ying et al. tackle this issue using an antisolvent and seeding strategy, resulting in a certified efficiency of 23.8%.

This work shows an iron molecular catalyst for water oxidation, a critical reaction for renewable energy technologies. The excellent performance of the catalyst is attributed to an intermediate dinuclear structure formed via spin crossover.

Atomically thin layers of a correlated topological semimetal exhibit a nonlinear Hall effect that can be used to fabricate terahertz photodetectors with a room-temperature responsivity of 0.3 A W⁻¹, a broadband terahertz range and a picosecond response time.

Land surface modelling suggests that preserving woody debris in managed forests could remove 769–937 GtCO₂ from the atmosphere between 2025 and 2100.

The treatment of poorly differentiated thyroid cancer and anaplastic thyroid cancer remains challenging. Here, the authors perform multi-omic analysis of thyroid samples and identify proteomic clusters associated with distinct tumour microenvironment features.

Both soil heterotrophic respiration and soil respiration increased globally during 1980-2022 and rising temperature enhanced the proportion of heterotrophic respiration to soil respiration, according to analysis of ground observation data combined with machine learning models.

This work demonstrates that epitaxial match at the oxide-support interfaces plays a critical role in determining whether supported metal nanoparticles oxidize from the interface or the free surface in oxygen, thereby enabling controlled oxidation.

In a prespecified interim analysis of the randomized, double-blind phase 3 COMPASSION-15 trial, patients with advanced HER2-negative gastric/GEJ cancer treated with the anti-PD-L1/CTLA-4 bispecific Ab cadonilimab plus chemotherapy showed significantly improved overall survival compared with patients treated with placebo plus chemotherapy as first-line treatment.

The authors demonstrate that the response of the flexural vibrations of twisted bilayer graphene can be hysteretic depending on the angle between the lattices of the layers, finding that the quality factors of the vibrations are enhanced compared to untwisted bilayers.

This study introduces a concept of persistent disruption, which marks papers that disrupt previous work but remain undisrupted later, signaling lasting impact. Milestone papers are found to be consistently associated with persistent disruption.

Yang et al. developed a new method, BEPH, a foundation model trained on TCGA WSI images. BEPH improves cancer recognition, classification, and survival prediction across subtypes, potentially reducing reliance on expert annotations.

The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.

Phase-switchable preparation of two-dimensional WS₂ is achieved through an electrochemical Li⁺ intercalation-based exfoliation strategy. A low discharge current density with high cutoff voltage produces pure semiconducting 2H phase WS₂ bilayers, while a higher discharge current density with a lower cutoff voltage favours semimetallic 1T′ phase WS₂ monolayers.

Worldwide, the number of only-child families is increasing. This research examines how growing up without siblings affects adult brain structure, function and connectivity, cognition, personality and mental health.

A millimetre-scale bioresorbable optoelectronic system with an onboard power supply and a wireless, optical control mechanism is developed for general applications in electrotherapy and specific uses in temporary cardiac pacing.

Serine metabolism is essential for leukemogenesis and stemness in acute myeloid leukemia (AML). Here the authors show that targeting IGF2BP3 disrupts the serine synthesis pathway in AML cells in an RNA N⁶-Methyladenosine modification dependent manner, sensitizing AML cells to serine and glycine deprivation.

The authors introduce SelectID, an approach combining CRISPR-guided targeting with methylation-sensitive labeling to identify proteins interacting with methylated repetitive sequences. They suggest that CHD4 directly binds young LINE-1 retrotransposons, suppressing their activity.

Allylic substitution reaction of alkenes has been well-developed, but it has limitations, partly due to the intrinsic predilection for an inner-sphere mechanism. Herein, the authors present an outer-sphere mechanism in Rh-catalyzed allylic substitution reaction of simple alkenes using gem-difluorinated cyclopropanes as allyl surrogates.

This study reports oxygen functional group-coordinated p-block metal catalysts that optimize the adsorption strength of key H₂O₂ intermediates for the oxygen reduction reaction. An electrolyser based on electron-deficient Sn active sites achieves an energy efficiency of 43% for the electrosynthesis of H₂O₂ and is stable for over 200 h.

Socioeconomic status is multidimensional and can change over time. Xu, Lui, Ji et al. found dimension-specific, late-stage-specific and change-specific socioeconomic effects on brain, cognition, personality and emotion.

Herpes simplex encephalitis caused by HSV-1 is a common viral encephalitis with severe symptoms and poor prognosis. Here, the authors developed a new 3D human neurovascular unit (NVU) model in vitro that allows to probe the neuropathogenesis and therapeutics of HSV-1-associated encephalitis.

Using operando electrochemical processes, we found a way to restore oxygen-redox active materials exhibiting structural and voltage decay to their pristine state, providing a framework for the design of functional materials with zero thermal expansion.

Chemical recycling of plastic wastes is of great significance for sustainable development, which also represents challenges and opportunities for synthesis of value-added chemicals. Here, the authors report a general strategy to degrade polyesters via directly breaking the C-O bond by nucleophilic substitution of halide anion of ionic liquids.

While chemotherapy may initially be effective in patient with nasopharyngeal carcinoma (NPC), resistance often develops. Here, the authors identify PJA1 as a driver of resistance to docetaxel via inhibition of GSDME-mediated proptosis and target this using a PJA1 inhibitor to restore sensitivity in preclinical models of NPC.

Sun et al. report human lifespan changes in the brain’s functional connectome in 33,250 individuals, which highlights critical growth milestones and distinct maturation patterns and offers a normative reference for development, aging and diseases.

The cobalt-catalyzed intermolecular reductive coupling of alkenes and alkynes is attractive due to the unique reactivity and cost-effectiveness of cobalt catalysts. Here, the authors report an asymmetric desymmetric reductive coupling of electronically unbiased succinimide-containing cyclobutenes with internal alkynes via photoredox and cobalt dual catalysis.

This study uncovers a unique broad neutralization mechanism against rotavirus, where antibody 7H13 destabilizes the partial structure of the viral VP4 spike by acting on a critical residue switch located at the interface of multiple VP4 subunits.

Obesity is associated with increased gut permeability, and microbial products that are leaked from the gut may contribute towards obesity-associated inflammation. Here the authors show that the leakage of gut extracellular vesicles containing microbial DNA leads to bacterial DNA accumulation in pancreatic β-cells, promoting obesity-associated islet inflammation.

Superconductivity was recently discovered in La₄Ni₃O₁₀ under pressure in proximity to a density-wave phase. Here, by stabilizing a tetragonal form of La₄Ni₃O₁₀ at ambient pressure, the authors show that the density-wave state is crucial for the superconductivity, but the tetragonal structure is not.

An avian influenza H7N9 virus causes severe human disease, including acute and often lethal respiratory failure. Here, the authors report that plasma levels of angiotensin II, a regulatory peptide of the renin–angiotensin system, are associated with disease severity and fatal outcome in infected patients.

Many two-dimensional materials exhibit isotropic properties, but anisotropy can extend the functionality of future devices. Here, the authors fabricate field-effect transistors from single and few-layer rhenium disulfide and observe an anisotropic ratio of three to one along the two principle axes

In a prospective observational study, symptoms of anxiety and/or depression were associated with worse response to first-line treatment with immunotherapy in patients with advanced non-small-cell lung cancer.

This genome-wide association study on persistent hepatitis B virus (HBV) infection among Chinese confirms previously associated genetic loci while discovering a novel protective locus at 8p21.3. The study also demonstrates the nearby gene INST10 suppresses HBV replication in vitro.

Zhao et al. find that a macrophage subset migrates from the dura matter to reshape the cerebrospinal fluid microenvironment and promote metastasis and show that the secreted phosphoprotein 1–matrix metallopeptidase 14 axis can be targeted to inhibit this.