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Reactive capture—integrating CO₂ capture and electrochemical valorization—improves energy efficiency by eliminating gas-phase CO₂ desorption. Here, authors design a redox-active polymeric network to boost the direct conversion of captured CO₂ to multicarbon products with CO₂-free gas product stream.

By engineering the eukaryotic-derived Fanzor2-ωRNA system, Wei, Gao, Pan, Li and Chen developed a compact genome editor enNlovFz2, which demonstrated efficient genome-editing activity in vitro and in vivo, with a broad target-adjacent motif scope.

Poly(carboxybetaine) lipids enhance mRNA lipid nanoparticles efficacy and reduce their immunogenicity, being promising alternatives to poly(ethylene) glycol lipids used in traditional mRNA lipid nanoparticle formulations.

Scavenger receptor class A member 3 (SR-A3) is implicated in metabolic diseases, but its relationship with MAFLD remains unclear. Here, the authors show that SR-A3 is an important modulator of hepatic energy metabolism and is a potential therapeutic target against MAFLD.

Wei, Bai, Wang, and colleagues present HypnoS, a genetically-encoded fluorescent sensor for the real-time monitoring of intracellular adenosine (iAdo) in a cell type-specific manner. They monitor iAdo dynamics during seizures or sleep-wake cycles with high spatiotemporal resolution in the brain of living animals.

The Hachiman system is a novel bacterial defense system. Here, the authors demonstrate that the type I-B Hachiman system functions as a heterodimeric HamAB complex, in which the helicase and nuclease cooperate to counteract phage infection.

In this study, multiple μ-spatially offset Raman spectroscopy is used to determine blood glucose levels noninvasively in humans, achieving comparatively high accuracy in a clinical setting.

The isolation of compounds featuring an actinide–actinide bond is challenging. Now a well-defined Th(III) dimer with a Th–Th two-centre one-electron (2c-1e) σ bond and a 2c-1e π bond is synthesized. Theoretical and magnetic studies show that the open-shell singlet ground state and the two formal Th(III) centres exhibit strong antiferromagnetic coupling.

The α6β4 receptor has been considered an appealing therapeutic target for pain. Here, the authors determined the structures of α6β4 bound with its agonists, nicotine and tebanicline, providing molecular insights into its function.

In this Resource, authors profile peripheral immune cells from a total of 220 healthy volunteers from birth to over 90 years. This revealed that T cells were most affected by aging with divergent aging patterns in different subsets and identified a population of cytotoxic B cells that were enriched in children.

Aragonite-dominated seep carbonates are a promising archive for understanding past seawater chemistry changes, according to an isotopic analysis of a core from the South China Sea.

Although flexible thermoelectric materials based on conducting polymers are attractive for energy harvesting, their performance is inferior to their inorganic counterparts. Here, the authors present a facile method to deliver inorganic nanowire films with high power factor and flexibility.

The lightning's nature is that different-polarity leaders extend in air. Only negative leaders' development was previously associated to floating plasma. We found that the floating plasma could also lead the positive leader stepwise development.

Here the authors show structures of the vesicular acetylcholine transporter in its apo state and in complex with the substrate acetylcholine and the inhibitor vesamicol, providing insights into substrate recognition, proton coupling and conformational transition mechanisms.

Minimizing the non-radiative energy loss without sacrificing the charge collection efficiency is the key to improve the performance of organic solar cells. Here, the authors develop hybrid side chain-based asymmetric small molecule acceptors and achieve maximum power conversion efficiency of 19.76%.

This article presents a polymeric membrane-enclosed insulin crystal equipped with physiological signal-sensing microdomains, dubbed ‘smart drug crystals’, that enables long-term, glucose- and β-hydroxybutyrate-dually responsive drug release for type 1 diabetes therapy.

Nanotwinning strategies are widely recognized for their ability to substantially enhance the mechanical properties of materials. Here diamond with both penetrating and interlocked twins was synthesized, yielding a hardness of 276 GPa, which can be explained by diamond models that feature diverse twin configurations and dimensions.

Developing high-performance and mechanically robust active-layer systems is crucial to commercializing flexible organic solar cells. Here, authors design small molecule acceptors with ethyl ester side chains and achieve certified efficiency of over 19% for mechanically robust devices.

The challenging synthesis of thermodynamic-unfavored cis-olefins through catalytic cross-coupling reactions requires the synergistic interaction of substrate activating units and configuration-regulating catalysts. Herein, the authors report a photoredox access to Z-alkenes from alkynes and light alkanes with a bifunctional iron-catalyzed system.

Despite being a promising treatment for hepatocellular carcinoma (HCC), resistance to tyrosine kinase inhibitors (TKI) present a major obstacle. Here, the authors demonstrate that lipid metabolism reprogramming via URI mediated stearoyl-CoA desaturase 1 upregulation present a targetable driver of sorafenib resistance in HCC.

Wei et al. identify the HDL receptor SR-B1 as a host factor that enhances infection of cultured cells with SARS-CoV-2 in the presence of ACE2, thus providing a possible molecular connection between lipoprotein metabolism and COVID-19.

Here, the authors identify key DNA methylation sites associated with incident acute coronary syndrome (ACS), improving ACS prediction and highlighting potential biomarkers and therapeutic targets for ACS.

Performing CO₂ reduction in acidic conditions enables high CO₂ utilization. Here, the authors report an electrodeposited Cu catalyst which achieves a 60% faradaic efficiency for ethylene and 90% for multicarbon products–both records for acidic CO₂ reduction.

A new surface passivator cyclohexane 1,4-diammonium diiodide naturally contains two isomeric structures with ammonium groups on the same or opposite sides of the hexane ring, and the two isomers demonstrate completely different surface interaction behaviours.

Authors find that freestanding single crystalline antiferroelectric PbZrO₃ membranes exhibit remarkable flexibility that can endure a maximum bending strain of 3.5%, with the assistance of mechanical-induced antiferroelectric-ferroelectric phase transition.

Single-atom catalysts are very attractive due to their ability to maintain high activities at the lowest possible precious metal loading. Here, a double transition metal MXene that effectively anchors single Pt atoms is reported, and exhibits superior performance and stability towards the hydrogen evolution reaction.

The cell membranes of many archaea contain characteristic membrane-spanning lipids known as glycerol dibiphytanyl glycerol tetraethers. Here, Zeng et al. identify a protein that participates in a key step of the synthesis of these lipids from diether precursors.

Thin Li foils are desirable for high-energy Li battery applications. Here, Cui and team devise a fabrication route for ultrathin (less than 20 μm) Li foils that show promise for improving existing anodes including silicon, graphite and metallic Li.

Cryo-electron microscopy structures of the noradrenaline transporter (NET) reveal binding modes of adrenaline, coordination of sodium and chloride ion binding and the binding sites and mechanisms of inhibition by conotoxin, bupropion and ziprasidone.

The room-temperature self-healing behaviour of a nanotwinned diamond composite is quantitatively evaluated and found to stem from both the formation of nanoscale diamond osteoblasts and the atomic interaction transition from repulsion to attraction.

Glacial-interglacial cycles drove lithium-rich brine formation in the Qarhan Salt Lake in China, according to Th dating and fluid inclusion analyses in halite, and paleotemperature reconstructions.

Controlled radical polymerization of fluorinated monomers typically synthesizes fluoropolymers of limited molecular weights with poor control. Now the controlled copolymerization of various fluoroalkenes under ambient conditions is reported by combining a redox-relay pathway and thermally activated delayed fluorescence catalysis.

Wearable sensors with edge computing are desired for human motion monitoring. Here, the authors demonstrate a topographic design for wearable MXene sensor modules with wireless streaming or in-sensor computing models for avatar reconstruction.

Arctic atmospheric rivers (ARs) have been increasing faster over the Atlantic sector than the Pacific sector in recent decades. The observed phase shift of interdecadal climate oscillations is key to explaining this disparity in Arctic AR trends.

Immunological adjuvants are a crucial component of cancer vaccines. Here the authors design a light-activable immunological adjuvant, based on hypoxia-responsive amphiphilic dendrimer nanoparticles loaded with a photodynamic agent, promoting anti-tumor immune responses in preclinical cancer models.

Addictive substances may impair cognitive flexibility. Here the authors show that in rodents, increased activity of striatal direct-pathway medium spiny neurons (dMSNs) in response to cocaine inhibits cholinergic interneurons (CINs), reducing cognitive flexibility.

The reversibility of lithium metal batteries is strongly influenced by the chemistry of the solid electrode interphase. Here the authors report a salt-philic and solvent-phobic interfacial design that leads to the formation of a robust interphase, considerably improving the cycle life of batteries.

Electrolyte engineering has proven an effective approach to enhance the performance of lithium metal batteries. Here the authors propose a strategy by using multiple solvents in weakly solvating electrolytes—dubbed as high-entropy electrolytes—to improve the ionic conductivity while maintaining electrochemical stability, leading to high-performance batteries.

Carpinus fangiana exhibits intermediate morphology between C. viminea and Ostrya rehderiana. Here, the authors report that Carpinus sect. Distegocarpus likely originate through homoploid hybrid speciation (HHS) during the early divergence between Carpinus and Ostrya through genomic analyses.