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LepR⁺ cells senescence is a driver of aging-induced bone marrow homeostasis collapse. Here, Li et al. report a LepR⁺ cell-targeting nitric oxide (NO) nanopump for rejuvenation of senescent LepR⁺ cells via activation of glycolysis signaling to reestablish homeostasis of the aged bone marrow.

Analysis combining multiple global tree databases reveals that whether a ___location is invaded by non-native tree species depends on anthropogenic factors, but the severity of the invasion depends on the native species diversity.

Breast cancer cells interact with cancer-associated adipocytes in the microenvironment. Here, the authors report that the cross-talk between these two cell types is dependent on Zeb1, which remodels the tumor-associated adipose microenvironment to confer breast cancer progression.

Species’ traits and environmental conditions determine the abundance of tree species across the globe. Here, the authors find that dominant tree species are taller and have softer wood compared to rare species and that these trait differences are more strongly associated with temperature than water availability.

Every spring, Bogong moths use the starry night sky as a compass to navigate up to 1,000 km towards their alpine migratory goal.

Microwave-assisted tumour-derived microparticles enhance antitumour activity, safety and drug delivery, outperforming traditional ultraviolet-derived methods.

Perovskite solar cells often rely on ordered molecular contacts for favourable charge-carrier transport, and any organizational disruption reduces device efficiency. Now a contact featuring an orthogonal π-skeleton has been shown to afford a high resilience to external stimuli plus long-term durability in accelerated-ageing tests.

A novel covalent inhibitor, ISM3312, targets the main protease of multiple human coronaviruses, including drug-resistant strains, and shows broad antiviral activity. It offers a promising therapeutic strategy against current and future coronavirus threats.

Prime editors are restricted to performing precise edits downstream of cleavage sites. Here, authors develop helicase-assisted circular RNA-mediated inverse PEs (ciPEs) to increase editing efficiencies at previously challenging genomic sites, expanding the scope of precise genome editing.

Self-assembled monolayers targeting wide-bandgap perovskite solar cells are essential to reduce the open-circuit voltage loss. Here, the authors report the stepwise tuning of interfacial energy level through inductive effect, achieving perovskite/TOPCon tandem solar cells with efficiency over 31%.

A computational framework to integrate microbial GWAS and single-cell RNA-sequencing profiles of 24 human organs reveals interactions between the host cells and microbes.

SERPINB9 (SPB9) has been reported as a critical factor in the resistance to immunotherapy but its role in chemosensitivity remains unknown. Here this work reports that gemcitabine (GEM) treatment leads to upregulation of SPB9 in vitro/vivo, therefore engineer a nanocarrier co-delivering GEM and siSPB9 for preclinical pancreatic cancer treatment.

Endothelial injury drives vascular diseases like atherosclerosis, but key regulators are unclear. Here, the authors show that endothelial major vault protein (MVP) acts as an intracellular regulator promoting Parkin-mediated mitophagy, thereby antagonizing vascular remodeling and suggesting its role as a potential therapeutic target.

Here, the authors target intratumoral T_reg cells to enhance antitumor immunity without affecting systemic T_reg cell function and identify JMJD1C as a critical epigenetic regulator of tumor T_reg cell fitness.

Conventional doping with hygroscopic dopants could lead to compromised device stability in perovskite solar cells. Here, the authors employ a combination of metal salt dopants to enhance doping efficiency and remove hygroscopic contaminants, realizing efficiency of over 25% for stable devices.

Non f-electron systems containing narrow electronic band and localized moments are a useful platform to study the Kondo lattice problem. Here, by using scanning tunneling microscopy, the authors show a transition from the insulating gap to a tuneable Kondo resonance in 1T-TaS₂ by Pb intercalation.

Radiotherapy-induced oral mucositis is a common side effect in nasopharyngeal carcinoma treatment. Here, the authors present a phase 3 randomized clinical trial assessing the safety and efficacy of ulinastatin to prevent the incidence and severity of this condition.

Stereotactic needle biopsies are currently performed for diagnosis only in glioblastoma; this study highlights the depth of information available through multi-omics analysis.

Many thrombolytic agents depend on plasminogen, leading to D-dimer accumulation. Here, Tang et al. report a plasminogen-independent thrombolytic enzyme that degrades blood clots and D-dimer without plasminogen.

The piezoelectricity of ferroelectric oxide films is limited by substrate clamping, and their rigidity hinders their applications in flexible electronics. Herein, authors report freestanding PbZr0.52Ti0.48O3 nanoscale membranes with both high piezoelectricity and high flexibility.

The partial replacement of the A-site by divalent methylenediammonium cations inhibits ion migration and photoinduced halide segregation in wide-bandgap perovskites. Single-junction devices achieve a certified power conversion efficiency of 22.71%, whereas perovskite/Cu(In,Ga)Se₂ tandem devices exhibit an efficiency of 30.13% in a four-terminal architecture.

RSV hijacks cholesterol or autophagy pathways to facilitate optimal replication. Here, the authors show that RSV-mediated changes in lysosomal cholesterol metabolism promote RSV-F accumulation in lysosomes by blocking autophagy flux, thereby facilitating viral replication.

Emerging pharmaceuticals that target metabolic and endocrine dysfunctions in polycystic ovary syndrome are transforming treatment paradigms. This article covers innovative drugs, including glucagon-like peptide 1 receptor agonists, sodium–glucose cotransporter 2 inhibitors, kisspeptin, neurokinin 3 receptor antagonists and artemisinins, exploring their mechanisms and potential to advance care for this disorder.

Until now, invisibility cloaks have only covered a region of a few wavelengths because of their nanostructured materials. Chenet al.describe a macroscopic cloak, made of calcite birefringent crystals, which works for a specific polarization at visible wavelengths.

Zheng and colleagues report that targeting both the death ___domain and the paracaspase ___domain of MALT1 with antisense oligonucleotides sensitizes resistant tumors to immune-checkpoint inhibition.

The study reveals how bortezomib activates Mycobacterium tuberculosis Clp protease complexes. Cryo-EM structures reveal how sub-stoichiometric bortezomib binding triggers structural changes, mediates holoenzyme formation and disrupts Clp system regulation.

Yu and colleagues present a single-cell transcriptomic landscape of olfactory neuroblastoma, characterizing different tumor subtypes and cancer cell responses to drug treatments.

Domestication of crops has boosted food production but increased dependence on fertilizers and pesticides. This study shows that wild rice harbors a higher abundance of nitrogen-fixing genes in the rhizosphere, while domesticated rice has more genes associated with nitrous oxide production.

Worldwide, the number of only-child families is increasing. This research examines how growing up without siblings affects adult brain structure, function and connectivity, cognition, personality and mental health.

A multi-ancestry genome-wide gene–smoking interaction study identifies 13 new loci associated with serum lipids.

In this partially randomized clinical trial, the authors find that an orally inhaled Ad5-nCoV booster is associated with a lower incidence of symptomatic COVID-19 during the following 6 months compared with controls who haven’t received a booster. Intramuscular administered Ad5-CoV booster is associated with reduced COVID-19 incidence as well.

Malignant pleural effusion is a challenge for cancer therapy. Here, the authors report on a piezoelectric nano-system that inhibits tumor growth in the thoracic cavity by piezo-generated reactive oxygen species using the intrapleural pressure, triggering immunogenic cell death, to treat malignant pleural effusion.

Hyperferritinemic syndrome is a collective term for a group of severe inflammatory conditions distinguished by high ferritin levels, including adult-onset Still’s disease and COVID-19. Here authors show in an animal model that high ferritin levels are not just a sign of hyperinflammation but also a pathogenic factor that triggers neutrophil leukocyte activation and extracellular trap formation.

Deuterated molecules are important both as labelled probes and as targets in their own right. Here the authors report a very simple and general deuteration of aldehydes, by the use of an N-heterocyclic carbene catalyst in the presence of D₂O.

Low-loss superconducting aluminium cables and on-chip impedance transformers can be used to link qubit modules and create superconducting quantum computing networks with high-fidelity intermodule state transfer.

Chromatin topology can impact gene regulation. Here, Wu et al. show that evolutionary changes in chromatin structure, particularly CTCF loops, can drive distinct transcriptional landscapes and isoform diversity contributing to human-specific traits.