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Here the authors report asperigimycins, fungal ribosomally synthesized and post-translationally modified peptides with a heptacyclic scaffold. After chemically modifying them for nanomolar anticancer activity, CRISPR screening identifies SLC46A3 as a key transporter for their uptake in cells.

A clinical study of women with abnormal breast mammograms establishes a workflow to evaluate the capability of breast photoacoustic computed tomography in the classification, monitoring and segmentation of lesions.

Human NPCs show promise for stroke treatment, but challenges remain in neuron diversity and maturation time. Here, the authors describe the generation of FOXG1 progenitors from iPSCs that quickly mature into functional cortical neurons, enhancing stroke recovery in rats.

Phenotypic and functional heterogeneity of cancer associated fibroblasts (CAFs) has been reported in pancreatic ductal adenocarcinoma (PDAC). Here the authors show that epithelial MAPK activity promotes myofibroblastic differentiation of CAFs. Furthermore, the epithelial basal-like subtype is associated with a CAF phenotype characterized by elevated MAPK activity and TGF-β signalling, associated with T cell exclusion in PDAC.

Patients with advanced-stage lung cancer might discontinue immune-checkpoint inhibitor (ICI) treatment for various reasons, including toxicities, disease progression or disease remission. Nonetheless, treatment options in this setting are often limited and some patients might derive benefit from re-administration of a previously received ICI. In this Review, the authors summarize the available data on ICI rechallenge, including the reasons for discontinuation and the feasibility of rechallenge in various clinical scenarios, and highlight important unaddressed research questions.

Immune checkpoint inhibitors have shown some activity in patients with adrenocortical carcinoma (ACC), a rare aggressive malignancy with limited treatment options. Here the authors report the results of a phase 2 trial of camrelizumab (anti-PD1) plus apatinib (VEGFR inhibitor) for previously treated ACC.

Electrosynthesis of acetate from CO using renewable electricity faces low selectivity. Here, the authors report a cerium single atom modulated copper catalyst, where cerium atoms tailor the interfacial water structure, enabling highly selective CO-to-acetate conversion under pulsed electrolysis.

Zhao et al. find that a macrophage subset migrates from the dura matter to reshape the cerebrospinal fluid microenvironment and promote metastasis and show that the secreted phosphoprotein 1–matrix metallopeptidase 14 axis can be targeted to inhibit this.

Insulinomas develop from pancreatic β-cells and secrete insulin, but the underlying genetic defects are largely unknown. In this study, Cao et al. identify recurrent T372R mutations in the transcription factor YY1, and validate this hotspot mutation in 30% of insulinomas.

Adipose tissue macrophage (ATM) has been implicated in inflammation and obesity, but the underlying mechanisms are still unclear. Here the authors show that AMPK is suppressed in ATMs from mice fed with high fat diet, leading to subsequent activation of SUCLA2, over-production of succinate and IL-1β, and ultimately inflammation and obesity.

The authors reported an interfacial composite design that accommodates high oxide fraction and large stretchability, providing implications for developing stretchable composites with enhanced optical, electrical, thermal, and magnetic properties.

Absorption and accumulation of atmospheric microplastics by plant leaves occurs widely in the environment.

In complex high-dimensional systems like power grids or COVID-19 transmission, both causal dependencies and temporal information of key variables are essential for dissecting the underlying mechanisms governing system dynamics. This paper presents Causal-oriented Representation Learning Predictor, a neural network framework designed to jointly conduct causal analysis and multistep forecasting.

Thick-panel origami structures have applications across a wide range of engineering fields. However, forming seamless surfaces remains challenging. Here, the authors refine the design by eliminating grooves. They validate their approach with 3D-printed prototypes.

Baseline performance, benchmarks, and guidance for LLMs in biomedicine are limited. The authors assess four LLMs on 12 tasks, establish baselines, examine hallucinations, and provide recommendations for optimal LLM use.

A gene-edited pig liver transplanted into a human recipient remains functional after 10 days and indicates that porcine organs could help meet the growing demand for liver transplants.

Efficient catalysts for seawater electrolysis are crucial for sustainable hydrogen production but struggle with slow kinetics and low durability. Here, the authors report a molybdenum nitride catalyst that in situ generates ammonium groups, enhancing both performance and stability in natural seawater.

Searching non-charge-based devices is crucial for sustainable information processing. Here, the authors make a nonvolatile magnon field effect transistor at room temperature, enabling efficient magnon transport control via the gate voltage pulses.

Strongly correlated systems exhibit universal dynamics near phase transitions, from particle to condensed matter physics. However, despite the successes of various theoretical approaches, systematic treatments of fluctuations are scarce. Here the authors unveil a universal damping of pseudo-Goldstone modes in systems with approximate symmetries, advancing our understanding of near-critical dynamics in several contexts.

It has been previously reported that the natural cytotoxic receptor NKp46 plays an important role in regulating natural killer (NK) cell biology. Here the authors show that NKp46 is required for the proliferation and cytotoxicity of type 1 innate lymphoid cells (ILCs) by activating the NF-κB signaling pathway and regulating IL-2Rα expression.

An enhanced superconducting pairing temperature (T_g) has only been observed in single-layer FeSe interfaced with TiO_x system. Here, the authors construct a new interface composed of single-layer FeSe interfaced with LaFeO₃ showing a highest T_g of 80 K among all-known interfacial superconductors.

High-quality micron-thick perovskite films with high-Miller-index-oriented grains can be used to achieve high-performance solar cells and modules.

A hafnium oxide memristor crossbar array integrated with transistors can provide a provable key destruction scheme in which unique physical fingerprints are extracted by comparing the conductance of neighbouring memristors, and can only be revealed if a digital key stored on the same array is erased.

The fabrication of artificial crystals by reassembling monolayer semiconductors enables on-demand engineering of their excitonic properties. Here, the authors report an efficient stacking method to fabricate millimetre-scale van der Waals homo-/hetero-crystals, demonstrating enhanced monolayer-like photoluminescence emission and quadrupolar interlayer exciton emission.

Nanospace defined by unsaturated metal coordination sites opens up the possibility of controlling and templating chemical reactivity. Here, the authors show that a Fe(III) dicarboxylate framework with triangularly arranged metal sites can direct the [2+2+2] cyclisation of nitriles, alkynes and alkenes.

This study maps proteomic changes in Alzheimer’s mouse models, identifying shared pathways with humans, amyloid-driven protein turnover, and proteome-transcriptome differences, offering insights into disease mechanisms and potential targets.

Skyrmions and fractional skyrmions are promising for spintronics applications but are challenging to create, observe, and manipulate, with a limited understanding of their impact on colloid dynamics. Here authors demonstrate the creation and light-actuated transformation of skyrmion textures in nematic liquid crystals, enabling colloidal assemblies and dynamic behaviors.

In pancreatic duct adenocarcinoma, super-enhancer RNAs (seRNAs) have higher N⁶-methyladenosine (m⁶A) levels than in adjacent normal tissue due to upregulation of the METTL3 cofactor CFL1. Aberrant m⁶A seRNAs promote oncogene expression via the YTHDC2–MLL1 complex.

Examining the in-plane spin components of the noncoplanar antiferromagnet manganese ditelluride provides spectroscopic and computational evidence of materials with a new type of plaid-like spin splitting in the antiferromagnetic ground state.

Perovskite solar cells often rely on ordered molecular contacts for favourable charge-carrier transport, and any organizational disruption reduces device efficiency. Now a contact featuring an orthogonal π-skeleton has been shown to afford a high resilience to external stimuli plus long-term durability in accelerated-ageing tests.

The trade-off between dexterity and payload capacity has limited the broad application of advanced aerial manipulation systems. Here, the authors introduce the Aerial Elephant Trunk, an aerial continuum manipulator, capable of performing operations in constrained and densely clustered environments.

Interface engineering by local polarization is becoming increasingly important for tunable electronics. Here, authors demonstrate an electric pulse-tuned piezotronic effect in Ag/HfO₂/n-ZnO junction, enabling reversible and accurate regulation of barrier height and piezotronic modification range.

Although ammonia synthesis represents a major chemical industry, developing highly effective non-iron catalysts is a challenging task. Now it has been shown that anchoring fullerene onto non-iron transition metals separates and activates catalytic sites for hydrogen and nitrogen intermediates, boosting ammonia synthesis rates.

The electro-oxidative synthesis of valued chemicals offers to enhance the overall efficiency and economic viability of renewable electrosynthesis systems. Here, the authors use dopant-tuned catalysts to promote the electrosynthesis of dimethyl carbonate from CO and methanol via oxidative carbonylation.

Ytterbium oxide buffer layer for use in perovskite solar cells yields a certified power conversion efficiency of more than 25%, which enhances stability across a wide variety of perovskite compositions.

Iron pnictide superconductors represent a suggestive alternative to cuprate superconductors for achieving high transition temperatures. Using in situ angle-resolved photoemission spectroscopy, the electronic properties of FeSe are examined as a function of film thickness, providing valuable insights into the mechanism driving the superconductivity in this material.

The long-term stability of perovskite solar cells remains a critical challenge for the commercialization of the technology. Here, the authors adopt a non-noble metal/metal oxide/polymer multiple-barrier to suppress device degradation, achieving long-term stability in encapsulated p-i-n devices.