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This work introduces DeepTernary, a deep learning method for rapid and accurate prediction of PROTAC and molecular glue-induced ternary complex structures, achieving state-of-the-art results by learning from a curated dataset, TernaryDB.

Here the authors report asperigimycins, fungal ribosomally synthesized and post-translationally modified peptides with a heptacyclic scaffold. After chemically modifying them for nanomolar anticancer activity, CRISPR screening identifies SLC46A3 as a key transporter for their uptake in cells.

The Einstein Probe has discovered a fast X-ray transient, EP240414a, associated with a broad-lined type Ic supernova. Its unusually soft spectrum and weak jet add to the diversity of stellar deaths and suggest a previously unknown Wolf–Rayet star explosion mechanism.

Sequence-based algorithms to identify T cell antigens often miss targets that are activating the immune response. Here authors show that a computational method they developed, which uses atomic level features as input, can identify antigens that trigger cytokine release in cognate T cells.

Structural vacancies in crystalline solids have potential in tuning optoelectronic properties. However, the random distribution of vacancies a problem when creating materials with completely reproducible functions. Here authors use vacancy engineering to improve electronic communication between cluster units in 3D orientationally ordered MOF crystals.

The authors study the non-centrosymmetric achiral material In_xTaS₂ by angle-resolved photoemission spectroscopy and quantum oscillations. They find that it hosts an “ideal” Kramers nodal line, well isolated at the Fermi level.

A new group of multi-principal-element alloys, designed through machine learning and extreme microstructural heterogeneities, achieve high strength (1.8-GPa yield strength) and ductility (25% uniform elongation) at room temperature.

Current synthetic gene switches face limitations including cytotoxicity and long-term side-effects. Here, authors present an aspirin-activated system, demonstrating the regulation of insulin expression in diabetic mice, restoring glucose levels, alleviating pain, and reducing biomarkers of inflammation.

Worldwide, the number of only-child families is increasing. This research examines how growing up without siblings affects adult brain structure, function and connectivity, cognition, personality and mental health.

Here, using samples from 146 mother-infant pairs and multi-omics, the authors characterize the dynamics of the gut microbiome, metabolome, and antibiotic resistance gene profiles during the first year of life in association with prenatal exposure to trace elements.

Patients with gastric cancer often present with poor performance status, limiting both quality of life but also treatment options as they are often excluded from clinical trials. Here, the authors report a phase II trial investigating anlotinib (multi-TKI) plus toripalimab (anti-PD-L1 monoclonal antibody) in treatment-naïve advanced gastric cancer patients with performance status 2.

The microglia–neuron interactions contributing to neuronal hyperexcitability are unclear. Here, the authors show how GABA and C3 signaling coordinate microglial engulfment of inhibitory synapses, driving excitatory–inhibitory imbalance and neuronal hyperexcitability in epilepsy.

The mechanism of HIV-1 latency reversal remains unclear. The authors suggest that PRMT3 drives the reversal by enhancing chromatin accessibility to form a transcriptional hub containing TEAD4 and P-TEFb at the viral promoter.

Polar skyrmions are a topological polarization texture. While they have now been detected in numerous material systems, near universally these have required careful strain engineering. Here, Xue, Zhang, Zheng, Tong, Wang and coauthors observe polar skyrmions in the van der Waals ferroelectric CuInP2S6, without strain-engineering.

First-instar orchid mantis nymphs avoid predators by mimicking black-red assassin bugs, whereas those in later instars avoid predators and attract prey by camouflaging themselves as lighter-coloured flowers. Here the authors use developmental transcriptomics, evolutionary genomics and predation experiments to reveal that this ontogenetic colour change is regulated by a pigment transporter called Redboy that emerged in Polyneoptera 284–197 million years ago.

Moiré patterns and flat bands usually occur in multilayer materials with a small interlayer twist angle, but this can cause detrimental lattice reconstruction. Now, flat bands are shown in a bilayer with large twist angle and structural rigidity.

Socioeconomic status is multidimensional and can change over time. Xu, Lui, Ji et al. found dimension-specific, late-stage-specific and change-specific socioeconomic effects on brain, cognition, personality and emotion.

Clinical trials of CD47 blocking antibody in human cancer patients have not yielded ideal results. Here the authors show that USP2 stabilizes CD47 through deubiquitination, whereas USP2 inhibition enhances macrophage phagocytosis, reprograms tumor microenvironment and synergizes with anti-PD-1 treatment.

Immune checkpoint blockade activates T cell immunity by reprogramming the STAT3 and STAT5 transcriptional pathways in dendritic cells, and STAT3 degradation is effective for treating tumours of multiple cancer types in mouse models.

Electrosynthesis of acetate from CO using renewable electricity faces low selectivity. Here, the authors report a cerium single atom modulated copper catalyst, where cerium atoms tailor the interfacial water structure, enabling highly selective CO-to-acetate conversion under pulsed electrolysis.

Organic phosphorescence materials offer advantages for bioimaging applications, but most of them are excited exclusively by ultraviolet light, which poses risks to living organisms. Here, the author report doped materials with white-light activated phosphorescence activity, and a bioimaging mode in which these phosphorescent materials are first concentrated within the organism and then excited.

Translation and rotation are the two most fundamental forms of diffusion. Here, the authors provide evidence of the coupling between rotation and translation under confinement, and find that asymmetric rotations disrupt the order of molecular diffusion in zeolites, which can be applied to studies of selective separation.

Non-invasive approaches for risk stratification and screening remain crucial for colorectal cancer (CRC). Here, the authors develop a model for CRC risk stratification by integrating plasma proteomics data with polygenic risk score and QCancer-15 risk score, which could guide recommendations for earlier screening of high-risk populations.

A multi-layer wafer-scale 2D gate-all-around system with an atomically smooth interface fabricated via epitaxial monolithic 3D integration shows good performance and power efficiency, holding promise for the forthcoming ångström technology node.

The death of massive stars has traditionally been discovered by explosive events in the gamma-ray band. Liu et al. show that the sensitive wide-field monitor on board Einstein Probe can reveal a weak soft-X-ray signal much earlier than gamma rays.

Metal-free catalysts offer a sustainable option for water oxidation but typically underperform compared to metal-based ones. Here, the authors report an all-organic catalyst that uses a rare oxide pathway to achieve high efficiency and long-term stability, comparable to metal-based systems.

The authors find the magnon spin transport in CrSP₄/Pt (Ta) can be effectively modulated through adjustments in temperature and applied magnetic field, particularly at the spin-flip field.

In a multicenter randomized phase 3 trial, stapokibart, a humanized monoclonal antibody that targets IL-4R alpha, significantly improved daily nasal and ocular symptom scores during the pollen phase in patients with moderate-to-severe seasonal allergic rhinitis.

The mechanism of gut microbiome and blood metabolites regulate the TME in multiple myeloma (MM) remain unclear. Here the authors show Lachnospiraceae can suppress MM cell phosphatidylcholine (PC) production, with the latter inhibiting CD8 T cell function via TP53 UFMylation elicited by exosomal SerpinB9 from multiple myeloma.

Adenoids and tonsils in children can become hypertrophic because of multiple infections. Here the authors use single cell transcriptomics to assess the immune cell composition of these hypertrophic organs and find B, T and NK cells and exhausted memory CD4 T cells indicating immune changes in these organs associated with respiratory infection.

Cross-ancestry genome-wide association studies of 3,414 brain imaging phenotypes in Chinese Han and white British participants identify autosomal and X-chromosomal associations in more diverse populations.

Distinguishing benign renal masses from malignant renal tumours, and further differentiating indolent from aggressive renal cancers, on computed tomography (CT) scans remains challenging. Here, the authors develop deep learning models for distinguishing benign from malignant renal masses, and differentiating indolent from aggressive renal tumours in a large cohort of preoperative CT scans, obtaining high accuracy and a strong association with clinical outcomes.

A wax-aided immersion methodology is developed to yield graphene rolls with tunable chiral angles; these graphene rolls exhibit promising chiral electronic properties beyond those of other carbon allotropes.

Infection with SARS-CoV-2 causes interstitial pneumonia and viral replication in the lungs of transgenic mice that express a human version of ACE2, confirming the pathogenicity of the virus in this model.

Twisted van der Waals structures represent a versatile platform to investigate topological and correlated electronic states. Here, the authors report the visualization of an electron crystal phase in twisted monolayer-bilayer graphene via scanning tunnelling microscopy, studying the coupling between strong electron correlation and nontrivial band topology.

Molecular tools enabling precise DNA mutations and targeted modulation of gene expression have significant potential in medicine and biology. Here, the authors develop a compact system for simultaneous and independent gene editing, activation, and repression in mammalian cells.

The transfer of nuclear chromatin to the cytoplasm drives the pro-aging inflammatory phenotype of senescent cells. Here, Miller et al. show that this process is suppressed by p53 and that activation of p53 reverses some features of aging in vivo.

Attempts to extend the range of reversible intercalation stoichiometries in selenides are promising but challenging. Here, authors report a reversible controlled superstoichiometric intercalation in NbSe₂ with up to two copper-ions per molecule by triggering anionic redox.